Synthesis and rat lens aldose reductase inhibitory activity of some benzopyran-2-ones

1986 ◽  
Vol 29 (6) ◽  
pp. 1094-1099 ◽  
Author(s):  
Abram N. Brubaker ◽  
Jack De Ruiter ◽  
William L. Whitmer
Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
JP Rodriguez ◽  
S Cho ◽  
J Lee ◽  
KH Lee ◽  
T Jin ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Seung Hwan Hwang ◽  
Shin Hwa Kwon ◽  
Set Byeol Kim ◽  
Soon Sung Lim

Stauntonia hexaphylla(Thunb.) Decne. (Lardizabalaceae) leaves (SHL) have been used traditionally as analgesics, sedatives, diuretics, and so on, in China. To date, no data have been reported on the inhibitory effect of SHL and its constituents on rat lens aldose reductase (RLAR) and advanced glycation end products (AGEs). Therefore, the inhibitory effect of compounds isolated from SHL extract on RLAR and AGEs was investigated to evaluate potential treatments of diabetic complications. The ethyl acetate (EtOAC) fraction of SHL extract showed strong inhibitory activity on RLAR and AGEs; therefore, EtOAc fraction (3.0 g) was subjected to Sephadex LH-20 column chromatography, for further fractionation, with 100% MeOH solvent system to investigate its effect on RLAR and AGEs. Phytochemical investigation of SHL led to the isolation of seven compounds. Among the isolated compounds, chlorogenic acid, calceolarioside B, luteolin-3′-O-β-D-glucopyranoside, quercetin-3-O-β-D-glucopyranoside, and luteolin-7-O-β-D-glucopyranoside exhibited significant inhibitory activity against RLAR with IC50in the range of 7.34–23.99 μM. In addition, 3-(3,4-dihydroxyphenyl) propionic acid, neochlorogenic acid, and luteolin-3′-O-β-D-glucopyranoside exhibited the most potent inhibitory activity against formation of AGEs, with an IC50value of 115.07–184.06 μM, compared to the positive control aminoguanidine (820.44 μM). Based on these findings, SHL dietary supplements could be considered for the prevention and/or treatment of diabetes complication.


2018 ◽  
Vol 15 (7) ◽  
pp. 796-812
Author(s):  
Saliha Bouknana ◽  
Mohamed Bouhrim ◽  
Hayat Ouassou ◽  
Mohamed Bnouham

2004 ◽  
Vol 56 (7) ◽  
pp. 941-945 ◽  
Author(s):  
Soon Sung Lim ◽  
Kuk Hyun Shin ◽  
Sang Hoon Jung ◽  
Kye Jung Shin ◽  
Dong Chan Kim ◽  
...  

2016 ◽  
Vol 10 (4) ◽  
pp. 534-542 ◽  
Author(s):  
Mounir Ghamali ◽  
Samir Chtita ◽  
Rachid Hmamouchi ◽  
Azeddine Adad ◽  
Mohammed Bouachrine ◽  
...  

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