Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 6. The Development of Predictive In Vitro Potency Models Using CoMFA and HQSAR Methodologies

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116019 ◽

2021 ◽

Vol 33 ◽

pp. 116019

Author(s):

Ikumi Kuriwaki ◽

Minoru Kameda ◽

Kazuhiko Iikubo ◽

Hiroyuki Hisamichi ◽

Yuichiro Kawamoto ◽

...

Keyword(s):

Systemic Exposure ◽

Pyrimidine Derivatives ◽

Structure Activity ◽

Orally Active

Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure–activity relationships (SARs) as antibacterial agent

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2010.08.010 ◽

2010 ◽

Vol 45 (11) ◽

pp. 5031-5038 ◽

Cited By ~ 21

Author(s):

Mazaahir Kidwai ◽

Roona Poddar ◽

Saurav Bhardwaj ◽

Satendra Singh ◽

Pratibha Mehta Luthra

Keyword(s):

Antibacterial Agent ◽

In Vitro Study ◽

Vitro Study ◽

Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 4. Effect of Substitution at C-3

Journal of Medicinal Chemistry ◽

10.1021/jm960200e ◽

1996 ◽

Vol 39 (15) ◽

pp. 2900-2906 ◽

Cited By ~ 35

Author(s):

Mitchell A. Avery ◽

Sanjiv Mehrotra ◽

Jason D. Bonk ◽

Jeffrey A. Vroman ◽

D. Keith Goins ◽

...

Keyword(s):

Antimalarial Agent ◽

Structure-activity relationships of steroids in inducing germinal vesicle breakdown of Atlantic croaker oocytes in vitro

General and Comparative Endocrinology ◽

10.1016/0016-6480(88)90259-6 ◽

1988 ◽

Vol 71 (2) ◽

pp. 307-317 ◽

Cited By ~ 72

Author(s):

John M. Trant ◽

Peter Thomas

Keyword(s):

Germinal Vesicle ◽

Atlantic Croaker ◽

Germinal Vesicle Breakdown ◽

Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum11Abbreviations: CDK, cyclin-dependent kinase; CDK1, cyclin-dependent kinase 1; and PfPK, Plasmodium falciparum protein kinase.

Biochemical Pharmacology ◽

10.1016/s0006-2952(01)00644-x ◽

2001 ◽

Vol 62 (3) ◽

pp. 341-348 ◽

Cited By ~ 37

Author(s):

Leonie Harmse ◽

Robyn van Zyl ◽

Nathanael Gray ◽

Peter Schultz ◽

Sophie Leclerc ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Protein Kinase ◽

In Vitro Growth ◽

Cyclin Dependent Kinase ◽

Purine Derivatives ◽

Inhibitory Effects ◽

Structure Activity ◽

Falciparum Protein

Advances in Experimental Medicine and Biology - Biological Reactive Intermediates IV ◽

Structure-Activity Relationships of Acrylate Esters: Reactivity Towards Glutathione and Hydrolysis by Carboxylesterase in Vitro

10.1007/978-1-4684-5877-0_42 ◽

1991 ◽

pp. 333-335 ◽

Cited By ~ 5

Author(s):

T. J. McCarthy ◽

G. Witz

Keyword(s):

Structure Activity ◽

Acrylate Esters

Structure-activity relationships of cysteine esters and their effects on thiol levels in rat lung in vitro

Biochemical Pharmacology ◽

10.1016/0006-2952(93)90301-c ◽

1993 ◽

Vol 45 (8) ◽

pp. 1605-1612 ◽

Cited By ~ 17

Author(s):

M.J. Hobbs ◽

M. Butterworth ◽

G.M. Cohen ◽

D.G. Upshall

Keyword(s):

Rat Lung ◽

Structure-activity relationships of tetramethylpiperidine-substituted phenazines against Mycobacterium leprae in vitro.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.33.11.2004 ◽

1989 ◽

Vol 33 (11) ◽

pp. 2004-2005 ◽

Cited By ~ 15

Author(s):

S G Franzblau ◽

K E White ◽

J F O'Sullivan

Keyword(s):

Mycobacterium Leprae ◽

Synthesis and Structure—Activity Relationships of Novel IKK-β Inhibitors. Part 2. Improvement of in vitro Activity.

ChemInform ◽

10.1002/chin.200449126 ◽

2004 ◽

Vol 35 (49) ◽

Author(s):

Toshiki Murata ◽

et al. et al.

Keyword(s):

Vitro Activity ◽

In Vitro Activity ◽

Quinazolinone Fungal Efflux Pump Inhibitors. Part 2. In vitro Structure?Activity Relationships of (N-Methyl-piperazinyl)-Containing Derivatives.

ChemInform ◽

10.1002/chin.200503155 ◽

2005 ◽

Vol 36 (3) ◽

Author(s):

William J. Watkins ◽

et al. et al.

Keyword(s):

Efflux Pump ◽

Structure Activity ◽

Efflux Pump Inhibitors