Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 8. Design, Synthesis, and CoMFA Studies toward the Development of Artemisinin-Based Drugs against Leishmaniasis and Malaria†

2003 ◽  
Vol 46 (20) ◽  
pp. 4244-4258 ◽  
Author(s):  
Mitchell A. Avery ◽  
Kannoth M. Muraleedharan ◽  
Prashant V. Desai ◽  
Achintya K. Bandyopadhyaya ◽  
Marise M. Furtado ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Antimalarial Agent ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 4. Effect of Substitution at C-3

1996 ◽  
Vol 39 (15) ◽  
pp. 2900-2906 ◽  
Author(s):  
Mitchell A. Avery ◽  
Sanjiv Mehrotra ◽  
Jason D. Bonk ◽  
Jeffrey A. Vroman ◽  
D. Keith Goins ◽  
...  
Keyword(s):  
Antimalarial Agent ◽  
Structure Activity Relationships ◽  
Structure Activity

Design, Synthesis, and Structure−Activity Relationships of Benzophenone-Based Tetraamides as Novel Antibacterial Agents

2009 ◽  
Vol 52 (16) ◽  
pp. 5020-5031 ◽  
Author(s):  
Sunil K. Vooturi ◽  
Chrissy M. Cheung ◽  
Michael J. Rybak ◽  
Steven M. Firestine
Keyword(s):  
Antibacterial Agents ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure–Activity Relationships

Synthesis ◽  
2016 ◽  
Vol 48 (17) ◽  
pp. 2739-2756 ◽  
Author(s):  
Daniele Piomelli ◽  
Eleonora Diamanti ◽  
Giovanni Bottegoni ◽  
Luca Goldoni ◽  
Natalia Realini ◽  
...  
Keyword(s):  
Acid Ceramidase ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

2020 ◽  
Vol 44 (6) ◽  
pp. 2247-2255
Author(s):  
Qifan Zhou ◽  
Lina Jia ◽  
Fangyu Du ◽  
Xiaoyu Dong ◽  
Wanyu Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Activity Assay ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Enhancer Of Zeste

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining with in vitro biological activity assay and docking results.

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