Resistance-Modifying Agents. 11.1Pyrimido[5,4-d]pyrimidine Modulators of Antitumor Drug Activity. Synthesis and Structure−Activity Relationships for Nucleoside Transport Inhibition and Binding to α1-Acid Glycoprotein

2004 ◽  
Vol 47 (20) ◽  
pp. 4905-4922 ◽  
Author(s):  
Nicola J. Curtin ◽  
Hannah C. Barlow ◽  
Karen J. Bowman ◽  
A. Hilary Calvert ◽  
Richard Davison ◽  
...  
Keyword(s):  
Antitumor Drug ◽  
Nucleoside Transport ◽  
Drug Activity ◽  
Acid Glycoprotein ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Transport Inhibition

Nucleoside Transport Inhibitors: Structure−Activity Relationships for Pyrimido[5,4-d]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α1-Acid Glycoprotein

2011 ◽  
Vol 54 (6) ◽  
pp. 1847-1859 ◽  
Author(s):  
Kappusamy Saravanan ◽  
Hannah C. Barlow ◽  
Marion Barton ◽  
A. Hilary Calvert ◽  
Bernard T. Golding ◽  
...  
Keyword(s):  
Nucleoside Transport ◽  
Pyrimidine Derivatives ◽  
Acid Glycoprotein ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Nucleoside Transport Inhibitors ◽  
Transport Inhibitors

Structure-Activity Relationships and Physiological Aspects of New Photosynthetic Electron Transport Inhibitors, 3-Alkylaminoalkyliden-2H-pyran-2,4(3H)-diones (APs)

1988 ◽  
Vol 43 (11-12) ◽  
pp. 857-861 ◽  
Author(s):  
Tadao Asami ◽  
Hiroyuki Koike ◽  
Yorinao Inoue ◽  
Nobutaka Takahashi ◽  
Shigeo Yoshida
Keyword(s):  
Electron Transport ◽  
Photosynthetic Electron Transport ◽  
Structural Requirement ◽  
Structure Activity Relationships ◽  
New Class ◽  
Structure Activity ◽  
Transport Inhibition ◽  
Transport Inhibitors

3-Aminoalkylidene-2H-pyran-2,4(3H)-diones (APs), possessing a conjugated enamino moiety which is common to cyanoacrylates and 2-aminoalkylidenecyclohexane-1,3-diones (ACs), were found as a new class of photosynthetic electron transport inhibitors. Although the structural requirement of APs for photosynthetic electron transport inhibition was very similar to that of cyanoacrylates and ACs, thermoluminescence measurements indicated that the binding manner of APs to D 1 protein was totally different from that of other inhibitors.

scholarly journals Structure–activity relationships for the binding of polymyxins with human α-1-acid glycoprotein

2012 ◽  
Vol 84 (3) ◽  
pp. 278-291 ◽  
Author(s):  
Mohammad A.K. Azad ◽  
Johnny X. Huang ◽  
Matthew A. Cooper ◽  
Kade D. Roberts ◽  
Philip E. Thompson ◽  
...  
Keyword(s):  
Acid Glycoprotein ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure-Activity Relationships of MDMA-Like Substances

1989 ◽  
Author(s):  
David E. Nichols ◽  
◽  
Robert Oberlender
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity

Structure-Activity Relationships in Cannabinoids: An Overview

1987 ◽  
Author(s):  
Raj K. Razdan ◽  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity

Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
Q Do ◽  
H Doan Thi Mai ◽  
T Gaslonde ◽  
B Pfeiffer ◽  
S Léonce ◽  
...  
Keyword(s):  
Pyran Ring ◽  
Structure Activity Relationships ◽  
Structure Activity
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