Nucleoside Transport Inhibitors: Structure−Activity Relationships for Pyrimido[5,4-d]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α1-Acid Glycoprotein

Structure Activity ◽

ChemInform Abstract: Nucleoside Transport Inhibitors: Structure-Activity Relationships and Potential Therapeutic Applications

ChemInform ◽

10.1002/chin.199745337 ◽

2010 ◽

Vol 28 (45) ◽

pp. no-no

Author(s):

J. K. BUOLAMWINI

Keyword(s):

Nucleoside Transport ◽

Therapeutic Applications ◽

Structure Activity ◽

Resistance-Modifying Agents. 11.1Pyrimido[5,4-d]pyrimidine Modulators of Antitumor Drug Activity. Synthesis and Structure−Activity Relationships for Nucleoside Transport Inhibition and Binding to α1-Acid Glycoprotein

Journal of Medicinal Chemistry ◽

10.1021/jm040772w ◽

2004 ◽

Vol 47 (20) ◽

pp. 4905-4922 ◽

Cited By ~ 32

Author(s):

Nicola J. Curtin ◽

Hannah C. Barlow ◽

Karen J. Bowman ◽

A. Hilary Calvert ◽

Richard Davison ◽

...

Keyword(s):

Antitumor Drug ◽

Nucleoside Transport ◽

Drug Activity ◽

Acid Glycoprotein ◽

Structure Activity ◽

Transport Inhibition

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116019 ◽

2021 ◽

Vol 33 ◽

pp. 116019

Author(s):

Ikumi Kuriwaki ◽

Minoru Kameda ◽

Kazuhiko Iikubo ◽

Hiroyuki Hisamichi ◽

Yuichiro Kawamoto ◽

...

Keyword(s):

Systemic Exposure ◽

Pyrimidine Derivatives ◽

Structure Activity ◽

Orally Active

Novel Hepatitis C virus replicon inhibitors: Synthesis and structure–activity relationships of fused pyrimidine derivatives

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.01.096 ◽

2012 ◽

Vol 22 (6) ◽

pp. 2212-2215 ◽

Cited By ~ 26

Author(s):

A. Chris Krueger ◽

Darold L. Madigan ◽

David W. Beno ◽

David A. Betebenner ◽

Robert Carrick ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Pyrimidine Derivatives ◽

Structure Activity

Inhibition of insulin-stimulated glucose transport in rat adipocytes by nucleoside transport inhibitors

FEBS Letters ◽

10.1016/0014-5793(88)80901-3 ◽

1988 ◽

Vol 227 (2) ◽

pp. 215-219 ◽

Cited By ~ 12

Author(s):

H.J. Steinfelder ◽

H.G. Joost

Keyword(s):

Glucose Transport ◽

Nucleoside Transport ◽

Rat Adipocytes ◽

Effects of nucleoside transport inhibitors and adenine/ribose supply on ATP concentration and adenosine production in cardiac myocytes

Cardiac Metabolism in Health and Disease ◽

10.1007/978-1-4615-5687-9_21 ◽

1998 ◽

pp. 193-199

Author(s):

Kameljit K. Kalsi ◽

Ryszard T. Smolenski ◽

Magdi H. Yacoub

Keyword(s):

Cardiac Myocytes ◽

Nucleoside Transport ◽

Atp Concentration ◽

Organ culture as a model for investigating the effects of antimetabolites and nucleoside transport inhibitors on rodent colonic mucosa

In Vitro Cellular & Developmental Biology ◽

10.1007/bf02630990 ◽

1991 ◽

Vol 27 (11) ◽

pp. 873-877

Author(s):

M. Moorghen ◽

P. Ince ◽

Karen J. Finney ◽

A. J. Watson ◽

A. L. Harris

Keyword(s):

Organ Culture ◽

Colonic Mucosa ◽

Nucleoside Transport ◽

Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011

Anti-Cancer Drugs ◽

10.1097/00001813-200201000-00003 ◽

2002 ◽

Vol 13 (1) ◽

pp. 29-36 ◽

Cited By ~ 17

Author(s):

Christopher R Boyer ◽

Patricia L Karjian ◽

Geoffrey M Wahl ◽

Mark Pegram ◽

Saskia TC Neuteboom

Keyword(s):

Antitumor Activity ◽

Nucleoside Transport ◽

Structure−Activity Relationships of a Series of Pyrrolo[3,2-d]pyrimidine Derivatives and Related Compounds as Neuropeptide Y5 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm000269t ◽

2000 ◽

Vol 43 (22) ◽

pp. 4288-4312 ◽

Cited By ~ 64

Author(s):

Mark H. Norman ◽

Ning Chen ◽

Zhidong Chen ◽

Christopher Fotsch ◽

Clarence Hale ◽

...

Keyword(s):

Pyrimidine Derivatives ◽

Receptor Antagonists ◽

Structure Activity ◽

Related Compounds

Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2013.11.132 ◽

2014 ◽

Vol 443 (2) ◽

pp. 505-510 ◽

Cited By ~ 1

Author(s):

Masahiro Kaneko ◽

Fumihiko Hakuno ◽

Hiroyasu Kamei ◽

Daisuke Yamanaka ◽

Kazuhiro Chida ◽

...

Keyword(s):

Steroid Hormones ◽

Nucleoside Transport ◽