Molecular Dynamics Simulation of the Ligand Binding Domain of Farnesoid X Receptor. Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding

2005 ◽  
Vol 48 (9) ◽  
pp. 3251-3259 ◽  
Author(s):  
Gabriele Costantino ◽  
Antonio Entrena-Guadix ◽  
Antonio Macchiarulo ◽  
Antimo Gioiello ◽  
Roberto Pellicciari
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulation ◽  
Ligand Binding ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Farnesoid X Receptor ◽  
Dynamics Simulation ◽  
Agonist Binding ◽  
Helix 12

Zn2+ion of the snake venom metalloproteinase (SVMP) plays a critical role in ligand binding: a molecular dynamics simulation study

RSC Advances ◽  
2015 ◽  
Vol 5 (86) ◽  
pp. 70566-70576 ◽  
Author(s):  
Sathishkumar Chinnasamy ◽  
Selvaraman Nagamani ◽  
Karthikeyan Muthusamy
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulation ◽  
Ligand Binding ◽  
Blood Coagulation ◽  
Snake Venom ◽  
Simulation Study ◽  
Tissue Damage ◽  
Critical Role ◽  
Dynamics Simulation ◽  
Snake Venom Metalloproteinase

Snake venom metalloproteinase (SVMP) is one of the major components of snake venom and it is a root causative agent for edema, local tissue damage, inflammation, blood coagulation and hemorrhage during the snake bite.

Sign in / Sign up

Export Citation Format

Share Document