Synthesis and SAR Studies of 2-Oxoquinoline Derivatives as CB2 Receptor Inverse Agonists

2006 ◽  
Vol 49 (6) ◽  
pp. 2022-2027 ◽  
Author(s):  
Katri H. Raitio ◽  
Juha R. Savinainen ◽  
Jouko Vepsäläinen ◽  
Jarmo T. Laitinen ◽  
Antti Poso ◽  
...  
Keyword(s):  
Cb2 Receptor ◽  
Inverse Agonists ◽  
Sar Studies

scholarly journals Mechanisms of Osteoclastogenesis Inhibition by a Novel Class of Biphenyl-Type Cannabinoid CB2 Receptor Inverse Agonists

2011 ◽  
Vol 18 (8) ◽  
pp. 1053-1064 ◽  
Author(s):  
Wolfgang Schuehly ◽  
Juan Manuel Viveros Paredes ◽  
Jonas Kleyer ◽  
Antje Huefner ◽  
Sharon Anavi-Goffer ◽  
...  
Keyword(s):  
Cb2 Receptor ◽  
Inverse Agonists

scholarly journals Trisubstituted Sulfonamides: A New Chemotype for Development of Potent and Selective CB2 Receptor Inverse Agonists

2013 ◽  
Vol 4 (4) ◽  
pp. 387-392 ◽  
Author(s):  
Qin Ouyang ◽  
Qin Tong ◽  
Rentian Feng ◽  
Kyaw-Zeyar Myint ◽  
Peng Yang ◽  
...  
Keyword(s):  
Cb2 Receptor ◽  
Inverse Agonists

Triaryl Bis-sulfones as a New Class of Cannabinoid CB2 Receptor Inhibitors: Identification of a Lead and Initial SAR Studies.

ChemInform ◽  
2005 ◽  
Vol 36 (25) ◽  
Author(s):  
Brian J. Lavey ◽  
Joseph A. Kozlowski ◽  
R. William Hipkin ◽  
Waldemar Gonsiorek ◽  
Daniel J. Lundell ◽  
...  
Keyword(s):  
Cb2 Receptor ◽  
New Class ◽  
Sar Studies

Synthesis and In Vitro Evaluation of Novel 2-oxo-1,2-dihydroquinoline CB2 Receptor Inverse Agonists

2006 ◽  
Vol 68 (6) ◽  
pp. 334-340 ◽  
Author(s):  
Katri H. Raitio ◽  
Juha R. Savinainen ◽  
Tapio Nevalainen ◽  
Tomi Järvinen ◽  
Jouko Vepsäläinen
Keyword(s):  
Cb2 Receptor ◽  
In Vitro Evaluation ◽  
Inverse Agonists

In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB2 receptor inverse agonists

2010 ◽  
Vol 61 (4) ◽  
pp. 349-354 ◽  
Author(s):  
Maria Grazia Cascio ◽  
Daniele Bolognini ◽  
Roger G. Pertwee ◽  
Enza Palazzo ◽  
Federico Corelli ◽  
...  
Keyword(s):  
Cb2 Receptor ◽  
Pharmacological Characterization ◽  
Inverse Agonists

New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands

2020 ◽  
Vol 44 (37) ◽  
pp. 16218-16226
Author(s):  
Claudia Mugnaini ◽  
Antonella Brizzi ◽  
Giorgia Vinciarelli ◽  
Marco Paolino ◽  
Federico Corelli
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Cb2 Receptor ◽  
Receptor Ligands ◽  
Inverse Agonists ◽  
Structure Activity ◽  
New Synthesis ◽  
Selective Agonists

This synthesis of pyrazolo[4,3-b]pyridine-5-one derivatives, recently described as potent and selective agonists/inverse agonists of the cannabinoid type-2 receptor (CB2R), allows for a wider exploration of the structure-activity relationship.

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