New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands

2020 ◽  
Vol 44 (37) ◽  
pp. 16218-16226
Author(s):  
Claudia Mugnaini ◽  
Antonella Brizzi ◽  
Giorgia Vinciarelli ◽  
Marco Paolino ◽  
Federico Corelli
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Cb2 Receptor ◽  
Receptor Ligands ◽  
Inverse Agonists ◽  
Structure Activity ◽  
New Synthesis ◽  
Selective Agonists

This synthesis of pyrazolo[4,3-b]pyridine-5-one derivatives, recently described as potent and selective agonists/inverse agonists of the cannabinoid type-2 receptor (CB2R), allows for a wider exploration of the structure-activity relationship.

scholarly journals Model structure–activity relationship studies of potential tropane 5HT1A, 5HT2A, and D2 receptor ligands

2012 ◽  
Vol 22 (7) ◽  
pp. 3148-3153 ◽  
Author(s):  
Tomasz Słowiński ◽  
Jacek Stefanowicz ◽  
Martyna Z. Wróbel ◽  
Franciszek Herold ◽  
Andrzej Mazurek ◽  
...  
Keyword(s):  
D2 Receptor ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Model Structure ◽  
Receptor Ligands ◽  
Structure Activity

3,4-Dihydro-3-amino-2H-1-benzopyran Derivatives as 5-HT1A Receptor Ligands and Potential Anxiolytic Agents. 1. Synthesis and Structure-Activity Relationship Studies

1994 ◽  
Vol 37 (12) ◽  
pp. 1779-1793 ◽  
Author(s):  
Tchao Podona ◽  
Beatrice Guardiola-Lemaitre ◽  
Daniel-Henri Caignard ◽  
Gerard Adam ◽  
Bruno Pfeiffer ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Receptor Ligands ◽  
Structure Activity

Synthesis and Structure−Activity Relationship of the First Nonpeptidergic Inverse Agonists for the Human Cytomegalovirus Encoded Chemokine Receptor US28

2005 ◽  
Vol 48 (20) ◽  
pp. 6461-6471 ◽  
Author(s):  
Janneke W. Hulshof ◽  
Paola Casarosa ◽  
Wiro M. P. B. Menge ◽  
Leena M. S. Kuusisto ◽  
Henk van der Goot ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Chemokine Receptor ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Inverse Agonists ◽  
Structure Activity ◽  
Relationship Of

Synthesis, Structure−Activity Relationship, and Evaluation of SR141716 Analogues:  Development of Central Cannabinoid Receptor Ligands with Lower Lipophilicity

2003 ◽  
Vol 46 (4) ◽  
pp. 642-645 ◽  
Author(s):  
Reeti Katoch-Rouse ◽  
Olga A. Pavlova ◽  
Tara Caulder ◽  
Alexander F. Hoffman ◽  
Alexey G. Mukhin ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Receptor Ligands ◽  
Structure Activity

scholarly journals Structure–activity relationship study on senktide for development of novel potent neurokinin-3 receptor selective agonists

MedChemComm ◽  
2015 ◽  
Vol 6 (3) ◽  
pp. 469-476 ◽  
Author(s):  
Ryosuke Misu ◽  
Koki Yamamoto ◽  
Ai Yamada ◽  
Taro Noguchi ◽  
Hiroaki Ohno ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Proteolytic Digestion ◽  
Structure Activity ◽  
Selective Agonist ◽  
Selective Agonists ◽  
Relationship Study ◽  
Neurokinin 3 Receptor

A potent neurokinin-3 receptor (NK3R) selective agonist with resistance to proteolytic digestion was developed.

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