Conformationally Constrained κ Receptor Agonists: Stereoselective Synthesis and Pharmacological Evaluation of 6,8-Diazabicyclo[3.2.2]nonane Derivatives†

Christian Geiger; Christel Zelenka; Kirstin Lehmkuhl; Dirk Schepmann; Werner Englberger; Bernhard Wünsch

doi:10.1021/jm100182p

Conformationally Constrained κ Receptor Agonists: Stereoselective Synthesis and Pharmacological Evaluation of 6,8-Diazabicyclo[3.2.2]nonane Derivatives†

Journal of Medicinal Chemistry ◽

10.1021/jm100182p ◽

2010 ◽

Vol 53 (10) ◽

pp. 4212-4222 ◽

Cited By ~ 20

Author(s):

Christian Geiger ◽

Christel Zelenka ◽

Kirstin Lehmkuhl ◽

Dirk Schepmann ◽

Werner Englberger ◽

...

Keyword(s):

Stereoselective Synthesis ◽

Conformationally Constrained ◽

Receptor Agonists ◽

Pharmacological Evaluation ◽

Κ Receptor

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Methylated Analogues of Methyl (R)-4-(3,4-Dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as Highly Potent κ-Receptor Agonists: Stereoselective Synthesis, Opioid-Receptor Affinity, Receptor Selectivity, and Functional Studies

Journal of Medicinal Chemistry ◽

10.1021/jm0108395 ◽

2001 ◽

Vol 44 (17) ◽

pp. 2814-2826 ◽

Cited By ~ 35

Author(s):

Stella Soukara ◽

Christoph A. Maier ◽

Ursula Predoiu ◽

Andreas Ehret ◽

Rolf Jackisch ◽

...

Keyword(s):

Opioid Receptor ◽

Stereoselective Synthesis ◽

Receptor Selectivity ◽

Receptor Affinity ◽

Receptor Agonists ◽

Functional Studies ◽

Affinity Receptor ◽

Κ Receptor

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Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm701425k ◽

2008 ◽

Vol 51 (14) ◽

pp. 4315-4320 ◽

Cited By ~ 32

Author(s):

Christer Alstermark ◽

Kosrat Amin ◽

Sean R. Dinn ◽

Thomas Elebring ◽

Ola Fjellström ◽

...

Keyword(s):

Gastroesophageal Reflux ◽

Gabab Receptor ◽

Aminobutyric Acid ◽

Type B ◽

Receptor Agonists ◽

Pharmacological Evaluation ◽

Acid Type

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Stereoselective synthesis of novel 2′-(S)-CCG-IV analogues as potent NMDA receptor agonists

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.113099 ◽

2021 ◽

Vol 212 ◽

pp. 113099

Author(s):

Alex Maolanon ◽

Athanasios Papangelis ◽

David Kawiecki ◽

Tung-Chung Mou ◽

Jed T. Syrenne ◽

...

Keyword(s):

Nmda Receptor ◽

Stereoselective Synthesis ◽

Receptor Agonists

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Estimation of affinities and efficacies for κ-receptor agonists in guinea-pig ileum

British Journal of Pharmacology ◽

10.1111/j.1476-5381.1989.tb11871.x ◽

1989 ◽

Vol 96 (3) ◽

pp. 702-706 ◽

Cited By ~ 9

Author(s):

P. Leff ◽

I.G. Dougall

Keyword(s):

Guinea Pig ◽

Guinea Pig Ileum ◽

Receptor Agonists ◽

Κ Receptor

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Rabbit vas deferens: A specific bioassay for opioid κ-receptor agonists

European Journal of Pharmacology ◽

10.1016/0014-2999(81)90098-4 ◽

1981 ◽

Vol 73 (2-3) ◽

pp. 235-236 ◽

Cited By ~ 155

Author(s):

Tetsuo Oka ◽

Kazuko Negishi ◽

Mitsuaki Suda ◽

Teruhiko Matsumiya ◽

Toshiyuki Inazu ◽

...

Keyword(s):

Vas Deferens ◽

Receptor Agonists ◽

Rabbit Vas Deferens ◽

Κ Receptor

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An efficient and stereoselective synthesis of (2S,1′S,2′S)-2-(carboxycyclopropyl) glycine (LCCG-I): conformationally constrained l-glutamate analogues

Tetrahedron Asymmetry ◽

10.1016/s0957-4166(00)00434-1 ◽

2000 ◽

Vol 11 (22) ◽

pp. 4537-4541 ◽

Cited By ~ 6

Author(s):

Hassan Pajouhesh ◽

John Chen ◽

Seyed Hossein Pajouhesh

Keyword(s):

Stereoselective Synthesis ◽

Conformationally Constrained ◽

Glutamate Analogues

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Probes for Narcotic Receptor-Mediated Phenomena. 27.1Synthesis and Pharmacological Evaluation of Selective δ-Opioid Receptor Agonists from 4-[(αR)-α-(2S,5R)-4-Substituted-2,5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and Their Enantiomers

Journal of Medicinal Chemistry ◽

10.1021/jm0001222 ◽

2000 ◽

Vol 43 (16) ◽

pp. 3193-3196 ◽

Cited By ~ 16

Author(s):

M. Scott Furness ◽

Xiaoyan Zhang ◽

Andrew Coop ◽

Arthur E. Jacobson ◽

Richard B. Rothman ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonists ◽

Pharmacological Evaluation ◽

Δ Opioid Receptor ◽

Opioid Receptor Agonists

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Stereoselective Synthesis of 6-Substituted Decahydroisoquinoline-3-carboxylates: Intermediates for the Preparation of Conformationally Constrained Acidic Amino Acids

The Journal of Organic Chemistry ◽

10.1021/jo00104a051 ◽

1994 ◽

Vol 59 (25) ◽

pp. 7862-7869 ◽

Cited By ~ 9

Author(s):

Paul L. Ornstein ◽

Nancy K. Augenstein ◽

M. Brian Arnold

Keyword(s):

Amino Acids ◽

Stereoselective Synthesis ◽

Conformationally Constrained ◽

Acidic Amino Acids

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Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists

ACS Medicinal Chemistry Letters ◽

10.1021/acsmedchemlett.9b00050 ◽

2019 ◽

Vol 10 (5) ◽

pp. 792-799 ◽

Cited By ~ 2

Author(s):

Pingyuan Wang ◽

Daniel E. Felsing ◽

Haiying Chen ◽

Sweta R. Raval ◽

John A. Allen ◽

...

Keyword(s):

G Protein ◽

Dopamine D1 Receptor ◽

D1 Receptor ◽

Receptor Agonists ◽

Pharmacological Evaluation

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Expression of inducible nitric oxide synthase in mice: Pharmacological evaluation of adenosine receptor agonists

European Journal of Pharmacology ◽

10.1016/s0014-2999(96)00677-2 ◽

1996 ◽

Vol 316 (2-3) ◽

pp. 287-296 ◽

Cited By ~ 6

Author(s):

Shabbir M. Moochhala ◽

Wei-Min Hon ◽

Vikram J.S. Chhatwal ◽

Hoon-Eng Khoo

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Adenosine Receptor ◽

Adenosine Receptor Agonists ◽

Receptor Agonists ◽

Pharmacological Evaluation ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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