Rapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries

2012 ◽  
Vol 55 (22) ◽  
pp. 9562-9575 ◽  
Author(s):  
Takayoshi Suzuki ◽  
Yosuke Ota ◽  
Masaki Ri ◽  
Masashige Bando ◽  
Aogu Gotoh ◽  
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Keyword(s):  
Click Chemistry ◽  
Histone Deacetylase ◽  
Selective Inhibitors ◽  
Histone Deacetylase 8

scholarly journals Thermodynamics of Binding of Structurally Similar Ligands to Histone Deacetylase 8 Sheds Light on Challenges in the Rational Design of Potent and Isozyme-Selective Inhibitors of the Enzyme

Biochemistry ◽  
2014 ◽  
Vol 53 (48) ◽  
pp. 7445-7458 ◽  
Author(s):  
Raushan K. Singh ◽  
Takayoshi Suzuki ◽  
Tanmay Mandal ◽  
Narayanaganesh Balsubramanian ◽  
Manas Haldar ◽  
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Keyword(s):  
Histone Deacetylase ◽  
Rational Design ◽  
Selective Inhibitors ◽  
Histone Deacetylase 8

scholarly journals Discovery of histone deacetylase 8 selective inhibitors

2011 ◽  
Vol 21 (9) ◽  
pp. 2601-2605 ◽  
Author(s):  
Weiping Tang ◽  
Tuoping Luo ◽  
Edward F. Greenberg ◽  
James E. Bradner ◽  
Stuart L. Schreiber
Keyword(s):  
Histone Deacetylase ◽  
Selective Inhibitors ◽  
Histone Deacetylase 8

scholarly journals Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors

2017 ◽  
Vol 8 (8) ◽  
pp. 824-829 ◽  
Author(s):  
Taha Y. Taha ◽  
Shaimaa M. Aboukhatwa ◽  
Rachel C. Knopp ◽  
Naohiko Ikegaki ◽  
Hazem Abdelkarim ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Biological Evaluation ◽  
Selective Inhibitors ◽  
Design Synthesis ◽  
Histone Deacetylase 8 ◽  
Synthesis And Biological Evaluation

Design, Synthesis, and Biological Activity of NCC149 Derivatives as Histone Deacetylase 8-Selective Inhibitors

ChemMedChem ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. 657-664 ◽  
Author(s):  
Takayoshi Suzuki ◽  
Nobusuke Muto ◽  
Masashige Bando ◽  
Yukihiro Itoh ◽  
Ayako Masaki ◽  
...  
Keyword(s):  
Biological Activity ◽  
Histone Deacetylase ◽  
Selective Inhibitors ◽  
Design Synthesis ◽  
Histone Deacetylase 8

ChemInform Abstract: Discovery of Histone Deacetylase 8 Selective Inhibitors.

ChemInform ◽  
2012 ◽  
Vol 43 (11) ◽  
pp. no-no
Author(s):  
Weiping Tang ◽  
Tuoping Luo ◽  
Edward F. Greenberg ◽  
James E. Bradner ◽  
Stuart L. Schreiber
Keyword(s):  
Histone Deacetylase ◽  
Selective Inhibitors ◽  
Histone Deacetylase 8

scholarly journals The inhibition of histone deacetylase 8 suppresses proliferation and inhibits apoptosis in gastric adenocarcinoma

2015 ◽  
Vol 47 (5) ◽  
pp. 1819-1828 ◽  
Author(s):  
SHIYUAN SONG ◽  
YING WANG ◽  
PO XU ◽  
RUINA YANG ◽  
ZHIKUN MA ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Gastric Adenocarcinoma ◽  
Histone Deacetylase 8

Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview

2019 ◽  
Vol 164 ◽  
pp. 214-240 ◽  
Author(s):  
Suvankar Banerjee ◽  
Nilanjan Adhikari ◽  
Sk Abdul Amin ◽  
Tarun Jha
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase 8
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