Small Molecular Antibacterial Peptoid Mimics: The Simpler the Better!

2014 ◽  
Vol 57 (4) ◽  
pp. 1428-1436 ◽  
Author(s):  
Chandradhish Ghosh ◽  
Goutham B. Manjunath ◽  
Padma Akkapeddi ◽  
Venkateswarlu Yarlagadda ◽  
Jiaul Hoque ◽  
...  
Keyword(s):  
Peptoid Mimics

Synthesis and biological evaluation of stilbene‐based peptoid mimics against the phytopathogenic bacterium Xanthomonas citri pv. citri

2020 ◽  
Vol 77 (1) ◽  
pp. 343-353
Author(s):  
Yan Li ◽  
Xingdong Lin ◽  
Jianqing Hu ◽  
Jianbo Shuai ◽  
Yinan Wei ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Xanthomonas Citri ◽  
Phytopathogenic Bacterium ◽  
Peptoid Mimics ◽  
Synthesis And Biological Evaluation

Peptoid mimics of a C2-symmetric inhibitor of the HIV-1 protease.

1994 ◽  
Vol 4 (11) ◽  
pp. 1281-1284 ◽  
Author(s):  
Jean-Paul Mazaleyrat ◽  
Isabelle Rage ◽  
Abdel Malek Mouna ◽  
Jaroslav Šavrda ◽  
Michel Wakselman ◽  
...  
Keyword(s):  
Peptoid Mimics ◽  
Hiv 1

scholarly journals Surface Behaviour of Peptoid Mimics of Pulmonary Surfactant Protein SP-C: Captive Bubble Surfactometry

2009 ◽  
Vol 96 (3) ◽  
pp. 352a
Author(s):  
Olga L. Ospina ◽  
David Schürch ◽  
Nate Brown ◽  
Annelise Barron ◽  
Jesús Pérez-Gil
Keyword(s):  
Pulmonary Surfactant ◽  
Surfactant Protein ◽  
Peptoid Mimics ◽  
Pulmonary Surfactant Protein

Evaluation of peptoid mimics of short, lipophilic peptide antimicrobials

2020 ◽  
Vol 56 (2) ◽  
pp. 106048 ◽  
Author(s):  
R. Madison Green ◽  
Kevin L. Bicker
Keyword(s):  
Peptoid Mimics ◽  
Lipophilic Peptide

Peptoid mimics of agouti related protein

2003 ◽  
Vol 13 (8) ◽  
pp. 1409-1413 ◽  
Author(s):  
Darren A. Thompson ◽  
Biao-Xin Chai ◽  
Hilary L.E. Rood ◽  
Michael A. Siani ◽  
Nicholai R. Douglas ◽  
...  
Keyword(s):  
Related Protein ◽  
Peptoid Mimics ◽  
Agouti Related Protein

scholarly journals Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides

2010 ◽  
Vol 55 (1) ◽  
pp. 417-420 ◽  
Author(s):  
Nathaniel P. Chongsiriwatana ◽  
Tyler M. Miller ◽  
Modi Wetzler ◽  
Sergei Vakulenko ◽  
Amy J. Karlsson ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Peptide ◽  
Broad Spectrum ◽  
Antimicrobial Lipopeptides ◽  
The Creation ◽  
Peptoid Mimics ◽  
Antimicrobial Potency

ABSTRACTWe report the creation of alkylated poly-N-substituted glycine (peptoid) mimics of antimicrobial lipopeptides with alkyl tails ranging from 5 to 13 carbons. In several cases, alkylation significantly improved the selectivity of the peptoids with no loss in antimicrobial potency. Using this technique, we synthesized an antimicrobial peptoid only 5 monomers in length with selective, broad-spectrum antimicrobial activity as potent as previously reported dodecameric peptoids and the antimicrobial peptide pexiganan.

scholarly journals Surface Rheological and Morphological Studies of Peptoid Mimics of Lung Surfactant Protein C

2010 ◽  
Vol 98 (3) ◽  
pp. 89a-90a
Author(s):  
Lin Wang ◽  
Nathan J. Brown ◽  
Annelise E. Barron
Keyword(s):  
Protein C ◽  
Lung Surfactant ◽  
Surfactant Protein ◽  
Surfactant Protein C ◽  
Morphological Studies ◽  
Peptoid Mimics ◽  
Lung Surfactant Protein

scholarly journals Functional Synergy between Antimicrobial Peptoids and Peptides against Gram-Negative Bacteria

2011 ◽  
Vol 55 (11) ◽  
pp. 5399-5402 ◽  
Author(s):  
Nathaniel P. Chongsiriwatana ◽  
Modi Wetzler ◽  
Annelise E. Barron
Keyword(s):  
Antimicrobial Activity ◽  
Innate Immunity ◽  
Antimicrobial Peptides ◽  
Inhibitory Concentration ◽  
Gram Negative Bacteria ◽  
Fractional Inhibitory Concentration ◽  
Gram Negative ◽  
Peptoid Mimics ◽  
Selective Antimicrobial Activity ◽  
Concentration Indices

ABSTRACTAntimicrobial peptides (AMPs) are integral components of innate immunity and are typically found in combinations in which they can synergize for broader-spectrum or more potent activity. Previously, we reported peptoid mimics of AMPs with potent and selective antimicrobial activity. Using checkerboard assays, we demonstrate that peptoids and AMPs can interact synergistically, with fractional inhibitory concentration indices as low as 0.16. These results strongly suggest that antimicrobial peptoids and peptides are functionally and mechanistically analogous.

scholarly journals Effective in vivo treatment of acute lung injury with helical, amphipathic peptoid mimics of pulmonary surfactant proteins

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Ann M. Czyzewski ◽  
Lynda M. McCaig ◽  
Michelle T. Dohm ◽  
Lauren A. Broering ◽  
Li-Juan Yao ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Pulmonary Surfactant ◽  
Surfactant Proteins ◽  
In Vivo Treatment ◽  
Peptoid Mimics ◽  
Pulmonary Surfactant Proteins

scholarly journals Helical Peptoid Mimics of Lung Surfactant Protein C

2003 ◽  
Vol 10 (11) ◽  
pp. 1057-1063 ◽  
Author(s):  
Cindy W Wu ◽  
Shannon L Seurynck ◽  
Ka Yee C Lee ◽  
Annelise E Barron
Keyword(s):  
Protein C ◽  
Lung Surfactant ◽  
Surfactant Protein ◽  
Surfactant Protein C ◽  
Peptoid Mimics ◽  
Lung Surfactant Protein
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