Synthesis and Biological Evaluation of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitors Based on a Thieno[2,3-d]pyrimidin-4(3H)-one Core

Annamaria Lilienkampf; Sampo Karkola; Sari Alho-Richmond; Pasi Koskimies; Nina Johansson; Kaisa Huhtinen; Kimmo Vihko; Kristiina Wähälä

doi:10.1021/jm900928k

Synthesis and Biological Evaluation of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitors Based on a Thieno[2,3-d]pyrimidin-4(3H)-one Core

Journal of Medicinal Chemistry ◽

10.1021/jm900928k ◽

2009 ◽

Vol 52 (21) ◽

pp. 6660-6671 ◽

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Author(s):

Annamaria Lilienkampf ◽

Sampo Karkola ◽

Sari Alho-Richmond ◽

Pasi Koskimies ◽

Nina Johansson ◽

...

Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Synthesis and biological evaluation of picolinamides as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

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Author(s):

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Shinae Kim ◽

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Hyun Joo Son ◽

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Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

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Synthesis and Biological Evaluation of Estradiol-Core Derivatives Bearing a Fused γ-Lactone as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1

Current Enzyme Inhibition ◽

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Author(s):

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Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Design, Synthesis, and Biological Evaluation of (Hydroxyphenyl)naphthalene and -quinoline Derivatives: Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) for the Treatment of Estrogen-Dependent Diseases

Journal of Medicinal Chemistry ◽

10.1021/jm701447v ◽

2008 ◽

Vol 51 (7) ◽

pp. 2158-2169 ◽

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Author(s):

Martin Frotscher ◽

Erika Ziegler ◽

Sandrine Marchais-Oberwinkler ◽

Patricia Kruchten ◽

Alexander Neugebauer ◽

...

Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Quinoline Derivatives ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

C6-(N,N-butyl-methyl-heptanamide) derivatives of estrone and estradiol as inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Chemical synthesis and biological evaluation

Bioorganic & Medicinal Chemistry ◽

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2007 ◽

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Keyword(s):

Chemical Synthesis ◽

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation ◽

Derivatives Of

Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.04.073 ◽

2008 ◽

Vol 16 (12) ◽

pp. 6423-6435 ◽

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Sandrine Marchais-Oberwinkler ◽

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...

Keyword(s):

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Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of (6- and 7-Phenyl) Coumarin Derivatives as Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1

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Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Coumarin Derivatives ◽

Synthesis And Biological Evaluation

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ChemInform ◽

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2004 ◽

Vol 35 (38) ◽

Author(s):

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Joonseop Kim ◽

Hyun-Ju Park

Keyword(s):

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Transforming Growth Factor ◽

Transforming Growth Factor Β1 ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of Lisofylline (LSF) Analogues as a Potential Treatment for Type 1 Diabetes.

ChemInform ◽

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Keyword(s):

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Potential Treatment ◽

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Synthesis and Biological Evaluation of Spiro-δ-lactones as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 2 (17β-HSD2)

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Rolf W. Hartmann ◽

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Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors

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Yan Zhang ◽

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Transforming Growth Factor Β ◽

Biological Evaluation ◽

Pyrazole Derivatives ◽

Synthesis And Biological Evaluation