Design, Synthesis, and in Vitro Activity of Catamphiphilic Reverters of Multidrug Resistance:  Discovery of a Selective, Highly Efficacious Chemosensitizer with Potency in the Nanomolar Range

1999 ◽  
Vol 42 (10) ◽  
pp. 1687-1697 ◽  
Author(s):  
Elisabetta Teodori ◽  
Silvia Dei ◽  
Patricia Quidu ◽  
Roberta Budriesi ◽  
Alberto Chiarini ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Design Synthesis ◽  
Nanomolar Range

scholarly journals Antitrypanosomal Activities of Proteasome Inhibitors

2002 ◽  
Vol 46 (6) ◽  
pp. 2038-2040 ◽  
Author(s):  
Joseph Nkemgu-Njinkeng ◽  
Vera Rosenkranz ◽  
Michael Wink ◽  
Dietmar Steverding
Keyword(s):  
Drug Development ◽  
Trypanosoma Brucei ◽  
Proteasome Inhibitors ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Data Support ◽  
Nanomolar Range

ABSTRACT Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development.

De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold

2005 ◽  
Vol 15 (4) ◽  
pp. 1161-1164 ◽  
Author(s):  
Dominique Potin ◽  
Michele Launay ◽  
Eric Nicolai ◽  
Maud Fabreguette ◽  
Patrice Malabre ◽  
...  
Keyword(s):  
De Novo ◽  
De Novo Design ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Design Synthesis

scholarly journals Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142678 ◽  
Author(s):  
Anna Mrozek-Wilczkiewicz ◽  
Ewelina Spaczynska ◽  
Katarzyna Malarz ◽  
Wioleta Cieslik ◽  
Marzena Rams-Baron ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Design Synthesis ◽  
Independent Mechanism

Design, synthesis, and in vitro activity of bis(succinimido)hexane peptide heterodimers with combined B1 and B2 antagonist activity

1994 ◽  
Vol 37 (3) ◽  
pp. 348-355 ◽  
Author(s):  
John C. Cheronis ◽  
Eric T. Whalley ◽  
Lisa G. Allen ◽  
Sharon D. Loy ◽  
Megan W. Elder ◽  
...  
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Antagonist Activity ◽  
Design Synthesis

Design, Synthesis, and in Vitro Activity of Novel 2′-O-Substituted 15-Membered Azalides

2012 ◽  
Vol 55 (7) ◽  
pp. 3216-3227 ◽  
Author(s):  
Dijana Pešić ◽  
Kristina Starčević ◽  
Ana Toplak ◽  
Esperanza Herreros ◽  
Jaume Vidal ◽  
...  
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Design Synthesis
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