Dynamic NMR studies of diastereomeric carbamates: implications toward the determination of relative configuration by NMR

1979 ◽  
Vol 44 (26) ◽  
pp. 4891-4896 ◽  
Author(s):  
W. H. Pirkle ◽  
Kirk A. Simmons ◽  
Charles W. Boeder
Keyword(s):  
Dynamic Nmr ◽  
Nmr Studies ◽  
Relative Configuration

ChemInform Abstract: DYNAMIC NMR STUDIES OF DIASTEREOMERIC CARBAMATES: IMPLICATIONS TOWARD THE DETERMINATION OF RELATIVE CONFIGURATION BY NMR

1980 ◽  
Vol 11 (18) ◽  
Author(s):  
W. H. PIRKLE ◽  
K. A. SIMMONS ◽  
C. W. BOEDER
Keyword(s):  
Dynamic Nmr ◽  
Nmr Studies ◽  
Relative Configuration

scholarly journals Synthesis of aminal-type Lilium candidum alkaloids and lilaline; determination of their relative configuration by the concerted use of NMR spectroscopy and DFT conformational analysis

Tetrahedron ◽  
2020 ◽  
pp. 131827
Author(s):  
Sándor Nagy ◽  
Áron Szigetvári ◽  
Viktor Ilkei ◽  
Balázs Krámos ◽  
Zoltán Béni ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Conformational Analysis ◽  
Relative Configuration

Synthesis and characterization of 19F NMR chelators for measurement of cytosolic free Ca

1987 ◽  
Vol 252 (4) ◽  
pp. C441-C449 ◽  
Author(s):  
L. A. Levy ◽  
E. Murphy ◽  
R. E. London
Keyword(s):  
Chemical Shifts ◽  
Cell Types ◽  
Free Calcium ◽  
Tetraacetic Acid ◽  
Nmr Studies ◽  
Cytosolic Free Calcium ◽  
Fluorine Nmr ◽  
Dissociation Constant Kd

Fluorine 19 nuclear magnetic resonance (NMR) studies of intracellular fluorinated calcium chelators provide a useful strategy for the determination of cytosolic free calcium levels in cells and perfused organs. However, the fluorinated chelator with the highest affinity for calcium ions which has been described to date. 1,2-bis-(2-amino-5-fluorophenoxy)ethane-N,N,N',N'-tetraacetic acid (5FBAPTA), exhibits a dissociation constant (Kd) value 5- to 10-fold greater than the intracellular calcium concentration levels in most cell types, thus limiting the ability of fluorine NMR to report these concentrations reliably. We have consequently designed and synthesized several fluorinated calcium chelators with higher affinity for calcium. The best of these, 2-(2-amino-4-methyl-5-fluorophenoxy)-methyl-8 aminoquinidine-N,N,N',N'-tetraacetic acid (quinMF), has a Kd value approximately 10 times lower than that of 5FBAPTA. Several of the newly synthesized indicators have different chemical shifts for the calcium complexed and uncomplexed chelators to allow the simultaneous use of two indicators. In addition to providing information about the level of cytosolic free calcium, chelators containing a quinoline ring exhibit considerable sensitivity to magnesium levels and hence have potential application for the determination of cytosolic-magnesium concentrations. Application of these chelators is illustrated by determination of the cytosolic-free calcium level in erythrocytes. Use of quinMF, the chelator with the lowest Kd value, gives a calcium value of 25-30 nM.

Determination of Relative Configuration in Organic Compounds by NMR Spectroscopy and Computational Methods

ChemInform ◽  
2007 ◽  
Vol 38 (50) ◽  
Author(s):  
Giuseppe Bifulco ◽  
Paolo Dambruoso ◽  
Luigi Gomez-Paloma ◽  
Raffaele Riccio
Keyword(s):  
Nmr Spectroscopy ◽  
Organic Compounds ◽  
Computational Methods ◽  
Relative Configuration

ChemInform Abstract: Dynamic NMR Studies of Phenyl Formate and 2,6-Dimethylphenyl Formate

ChemInform ◽  
1989 ◽  
Vol 20 (46) ◽  
Author(s):  
H. MARK ◽  
T. BAKER ◽  
E. A. NOE
Keyword(s):  
Dynamic Nmr ◽  
Nmr Studies

Determination of the Relative Configuration of β-Amino Acid Esters Based on Residual Dipolar Couplings

2015 ◽  
Vol 2015 (31) ◽  
pp. 6801-6805 ◽  
Author(s):  
Thomas Niklas ◽  
Christian Steinmetzger ◽  
Weiping Liu ◽  
Daniel Zell ◽  
Dietmar Stalke ◽  
...  
Keyword(s):  
Amino Acid ◽  
Residual Dipolar Couplings ◽  
Dipolar Couplings ◽  
Amino Acid Esters ◽  
Relative Configuration ◽  
Acid Esters

A simple and efficient synthesis and dynamic NMR studies of some new podands of dithiocarbamates formed from bis(naphthyl) derivatives

2011 ◽  
Vol 22 (5) ◽  
pp. 659-668 ◽  
Author(s):  
Abbas Shockravi ◽  
Mahmood Kamali ◽  
Farhad Sorkhei ◽  
Reza Jafari
Keyword(s):  
Dynamic Nmr ◽  
Efficient Synthesis ◽  
Nmr Studies

scholarly journals The use of carbonyl group anisotropy effect in determination of the relative configuration of carbapenams

ARKIVOC ◽  
2014 ◽  
Vol 2014 (3) ◽  
pp. 143-153 ◽  
Author(s):  
Olga Staszewska-Krajewska ◽  
Wojciech Bocian ◽  
Magdalena Maciejko ◽  
Piotr Szcześniak ◽  
Krzysztof Szymczak ◽  
...  
Keyword(s):  
Carbonyl Group ◽  
Relative Configuration ◽  
Anisotropy Effect
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