Diastereo- and Enantioselective Direct Catalytic Aldol Reaction of 2-Hydroxyacetophenones with Aldehydes Promoted by a Heteropolymetallic Complex:  Catalytic Asymmetric Synthesis ofanti-1,2-Diols

2002 ◽  
Vol 67 (8) ◽  
pp. 2556-2565 ◽  
Author(s):  
Naoki Yoshikawa ◽  
Takeyuki Suzuki ◽  
Masakatsu Shibasaki
Keyword(s):  
Asymmetric Synthesis ◽  
Aldol Reaction ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric

scholarly journals Catalytic asymmetric synthesis of CF3-substituted tertiary propargylic alcohols via direct aldol reaction of α-N3amide

2017 ◽  
Vol 8 (4) ◽  
pp. 3260-3269 ◽  
Author(s):  
Hidetoshi Noda ◽  
Fuyuki Amemiya ◽  
Karin Weidner ◽  
Naoya Kumagai ◽  
Masakatsu Shibasaki
Keyword(s):  
Asymmetric Synthesis ◽  
Hydroxamic Acid ◽  
Aldol Reaction ◽  
Propargylic Alcohols ◽  
Catalytic Asymmetric Synthesis ◽  
Direct Aldol Reaction ◽  
Catalytic Asymmetric

The catalyst comprising Cu(ii)/chiral hydroxamic acid was found to play a bifunctional role in the direct aldol reaction of α-N3amide to alkynyl CF3ketones.

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