Application of Vicarious Nucleophilic Substitution to the Total Synthesis ofdl-Physostigmine

2003 ◽  
Vol 68 (16) ◽  
pp. 6133-6139 ◽  
Author(s):  
Pankaj D. Rege ◽  
Francis Johnson
Keyword(s):  
Total Synthesis ◽  
Nucleophilic Substitution ◽  
Vicarious Nucleophilic Substitution

First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine

Synthesis ◽  
2017 ◽  
Vol 49 (12) ◽  
pp. 2768-2774 ◽  
Author(s):  
Srinu Puvvala ◽  
Vinod Jadhav ◽  
Umesh Narkhede ◽  
M. Anji Karun ◽  
Ch. Venkata Ramana Reddy
Keyword(s):  
Total Synthesis ◽  
Nucleophilic Substitution ◽  
Natural Product ◽  
Ring Closure ◽  
One Pot ◽  
Vicarious Nucleophilic Substitution ◽  
Synthetic Sequence

A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in the total synthesis of a cytotoxic aaptamine derivative.

ChemInform Abstract: Asymmetric Aromatic Vicarious Nucleophilic Substitution of Hydrogen.

ChemInform ◽  
2010 ◽  
Vol 28 (23) ◽  
pp. no-no
Author(s):  
M. D. DREW ◽  
D. A. JACKSON ◽  
N. J. LAWRENCE ◽  
J. LIDDLE ◽  
R. G. PRITCHARD
Keyword(s):  
Nucleophilic Substitution ◽  
Nucleophilic Substitution Of Hydrogen ◽  
Vicarious Nucleophilic Substitution
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