scholarly journals Construction of the Tricyclic A-B-C Core of the Veratrum Alkaloids

2013 ◽  
Vol 78 (17) ◽  
pp. 8437-8441 ◽  
Author(s):  
Douglass F. Taber ◽  
James F. Berry
Keyword(s):  
Veratrum Alkaloids

Different actions of aconitine and veratrum alkaloids on frog skeletal muscle

1990 ◽  
Vol 21 (6) ◽  
pp. 863-868 ◽  
Author(s):  
Péter P. Nánási ◽  
Tamás Kiss ◽  
Miklós Dankó ◽  
David A. Lathrop
Keyword(s):  
Skeletal Muscle ◽  
Frog Skeletal Muscle ◽  
Veratrum Alkaloids

scholarly journals The role of Ca2+ in the protoveratrine-induced release of γ-aminobutyrate from rat brain slices

1980 ◽  
Vol 190 (2) ◽  
pp. 333-339 ◽  
Author(s):  
M C W Minchin
Keyword(s):  
Cerebral Cortex ◽  
Rat Brain ◽  
Dose Response ◽  
Transmitter Release ◽  
Response Curve ◽  
Brain Slices ◽  
Veratrum Alkaloids ◽  
Similar Dose ◽  
22Na Uptake

1. Protoveratrine A increased the release of gamma-amino[3H]butyrate from small slices of rat cerebral cortex. This effect increased with increasing protoveratrine concentration, reaching a maximum at 100 microM. 2. Removal of Ca2+ from the superfusing medium did not change the increase in release due to 10 microM-protoveratrine; however, the Ca2+ antagonists, compound D-600, La3+, Mn2+, Mg2+ and also high Ca2+ concentration inhibited the effect of the alkaloid, as did procaine. 3. Protoveratrine A increased the uptake of 22Na+ into the slices with a similar dose-response curve to that found for gamma-aminobutyrate release. For the most part, the substances that inhibited protoveratrine-stimulated gamma-aminobutyrate release also inhibited 22Na+ uptake, although the correlation was not perfect. 4. Although extracellular Ca2+ is not required for protoveratrine-induced gamma-aminobutyrate release, an increase in Na+ influx that is susceptible to inhibition by some Ca2+ antagonists does appear to be associated with this phenomenon. However, the possibility remains that changes in the free intracellular Ca2+ concentration may be important for transmitter release induced by depolarizing veratrum alkaloids.

Transannular Diels–Alder cyclization of a substituted 13-membered macrocyclic triene. An approach to the A.B.C.[6.6.5] rings of the Veratrum alkaloids

1992 ◽  
Vol 70 (9) ◽  
pp. 2335-2349 ◽  
Author(s):  
Miguel Quimpère ◽  
Luc Ruest ◽  
Pierre Deslongchamps
Keyword(s):  
Diels Alder ◽  
Oxygen Bridge ◽  
Veratrum Alkaloids ◽  
Tricyclic Compound

The synthesis and Diels–Alder cyclization of a substituted macrocyclic 13-membered triene 45 is described. Tricyclic compound A.B.C.[6.6.5] 46 having ring junctions of cis-anti-cis (CAC) stereochemistry was used to investigate the possibility of introducing a hemiketal oxygen bridge between positions 9 and 4 of the Veratrum alkaloid skeleton.

Veratrum Alkaloids XXXV

1959 ◽  
Vol 48 (12) ◽  
pp. 727-730 ◽  
Author(s):  
S. Morris Kupchan ◽  
Norbert Gruenfeld
Keyword(s):  
Veratrum Alkaloids

Neural control of shark rectal gland

1988 ◽  
Vol 255 (2) ◽  
pp. R212-R216 ◽  
Author(s):  
J. S. Stoff ◽  
P. Silva ◽  
R. Lechan ◽  
R. Solomon ◽  
F. H. Epstein
Keyword(s):  
Neural Control ◽  
Squalus Acanthias ◽  
Rectal Gland ◽  
Channel Blockers ◽  
Stimulatory Action ◽  
Histological Techniques ◽  
Neuronal Tissue ◽  
Neural Modulation ◽  
Veratrum Alkaloids ◽  
Gland Function

Veratrum alkaloids stimulated salt secretion by the isolated perfused rectal gland of Squalus acanthias. Stimulation by veratrine was prevented by the nerve channel blockers tetrodotoxin and procaine and was not evident in a preparation of dispersed rectal gland cells. Vasoactive intestinal peptide (VIP)-like immunoreactivity was detected by histological techniques in neuronal tissue within the rectal gland. Veratrine stimulation caused the release of immunoreactive VIP into the venous effluent of perfused glands. The stimulatory action of veratrine was inhibited by somatostatin, another neuropeptide known to be present in nerves of Squalus rectal gland. These findings suggest the likelihood of neural modulation of rectal gland function.

Administration of the Veratrum Alkaloids Protoveratrine and Cryptenamine in the Treatment of Hypertension

1955 ◽  
Vol 48 (7) ◽  
pp. 774-781
Author(s):  
ROBERT G. MCCONN ◽  
RALPH V. FORD ◽  
BARTIS M. KENT ◽  
WARREN M. HUGHES ◽  
EDWARD W. DENNIS ◽  
...  
Keyword(s):  
Veratrum Alkaloids ◽  
Treatment Of Hypertension

Conformations of 3-carboxylic esters essential for neurotoxicity in veratrum alkaloids are loosely restricted and fluctuate

2008 ◽  
Vol 16 (6) ◽  
pp. 3025-3031 ◽  
Author(s):  
Ai Niitsu ◽  
Masanori Harada ◽  
Tohru Yamagaki ◽  
Kazuo Tachibana
Keyword(s):  
Veratrum Alkaloids ◽  
Carboxylic Esters

Veratrum alkaloids

2009 ◽  
Vol &NA; (1236) ◽  
pp. 33
Author(s):  
&NA;
Keyword(s):  
Veratrum Alkaloids

Osmotically released vasopressin augments cardiopulmonary reflex inhibition of the circulation

1988 ◽  
Vol 254 (5) ◽  
pp. R815-R820 ◽  
Author(s):  
E. M. Hasser ◽  
S. E. DiCarlo ◽  
R. J. Applegate ◽  
V. S. Bishop
Keyword(s):  
Arterial Pressure ◽  
Carotid Sinus ◽  
Area Postrema ◽  
Conscious Dogs ◽  
Inhibitory Influence ◽  
Inhibitory Effects ◽  
Circumflex Coronary Artery ◽  
Depressor Response ◽  
Veratrum Alkaloids ◽  
Cardiopulmonary Receptors

Exogenous arginine vasopressin (AVP) has been shown to augment the inhibitory influence of arterial and cardiopulmonary baroreflexes. This study examined the influence of osmotically released AVP on the inhibitory responses to activation of cardiopulmonary receptors by administration of veratrum alkaloids. Three groups of conscious dogs, with carotid sinus intact, with prior sinoaortic denervation (SAD), and with prior lesion of the area postrema (AP), were instrumented for monitoring arterial pressure and heart rate and with left circumflex coronary artery or left atrial catheters for administration of veratrum alkaloids. Conscious dogs were administered veratridine (0.5-1.0 microgram.kg-1.min-1) under control conditions, after infusion of hypertonic saline (HS, 6% NaCl), and after HS in the presence of the AVP vascular (V1) receptor antagonist. In carotid sinus-intact dogs, veratridine reduced arterial pressure (-10 +/- 0.4 mmHg). After HS infusion, the depressor response to veratridine was significantly greater (-18 +/- 0.8 mmHg). The enhanced depressor response during HS infusion was prevented by administration of the AVP antagonist (-8 +/- 0.6 mmHg). Responses to veratrum alkaloids in SAD dogs were similar. In AP-lesioned animals, the depressor effects of veratridine (-9 +/- 0.5 mmHg) were similar to intact animals. However, the response to veratridine during HS was not altered (-9 +/- 0.8 mmHg) in AP-lesioned dogs. Results suggest that osmotically stimulated AVP augments the inhibitory effects of cardiopulmonary reflexes and that this effect is mediated through the area postrema via the V1 receptor.

Sign in / Sign up

Export Citation Format

Share Document