Total Synthesis of Epothilone D: The Nerol/Macroaldolization Approach

2013 ◽  
Vol 78 (21) ◽  
pp. 10588-10595 ◽  
Author(s):  
Ludger A. Wessjohann ◽  
Günther O. Scheid ◽  
Uwe Eichelberger ◽  
Sumaira Umbreen
Keyword(s):  
Total Synthesis ◽  
Epothilone D

Total Synthesis of Epothilone B, Epothilone D, andcis- andtrans-9,10-Dehydroepothilone D

2001 ◽  
Vol 123 (23) ◽  
pp. 5407-5413 ◽  
Author(s):  
James D. White ◽  
Rich G. Carter ◽  
Kurt F. Sundermann ◽  
Markus Wartmann
Keyword(s):  
Total Synthesis ◽  
Epothilone B ◽  
Epothilone D

The Total Synthesis of Epothilone D as a Yardstick for Probing New Methodologies

2016 ◽  
Vol 23 (3) ◽  
pp. 541-545 ◽  
Author(s):  
Alexander M. Haydl ◽  
Bernhard Breit
Keyword(s):  
Total Synthesis ◽  
Epothilone D ◽  
New Methodologies

ChemInform Abstract: Total Synthesis of Epothilone D: The Nerol/Macroaldolization Approach.

ChemInform ◽  
2014 ◽  
Vol 45 (15) ◽  
pp. no-no
Author(s):  
Ludger A. Wessjohann ◽  
Günther O. Scheid ◽  
Uwe Eichelberger ◽  
Sumaira Umbreen
Keyword(s):  
Total Synthesis ◽  
Epothilone D

Total Synthesis and Biological Evaluation of a C(10)/C(12)-Phenylene-Bridged Analog of Epothilone?D

2004 ◽  
Vol 1 (11) ◽  
pp. 1771-1784 ◽  
Author(s):  
Nicole End ◽  
Pascal Furet ◽  
Nathalie van?Campenhout ◽  
Markus Wartmann ◽  
Karl-Heinz Altmann
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Epothilone D ◽  
Synthesis And Biological Evaluation

scholarly journals Total Synthesis of Epothilone B, Epothilone D, andcis- andtrans-9,10-Dehydroepothilone D  [J. Am. Chem. Soc.2001,123, 5407−5413]. 

2003 ◽  
Vol 125 (10) ◽  
pp. 3190-3190 ◽  
Author(s):  
James D. White ◽  
Rich G. Carter ◽  
Kurt F. Sundermann ◽  
Markus Wartmann
Keyword(s):  
Total Synthesis ◽  
Epothilone B ◽  
Epothilone D

scholarly journals Studies toward the Total Synthesis of Epothilone D: Synthesis of the Thiazole-Containing Northern Segment

2019 ◽  
Vol 14 (9) ◽  
pp. 1934578X1986859
Author(s):  
Momoko Suzuki ◽  
Shougo Hashimoto ◽  
Shun Sakamoto ◽  
Hiroshi Kogen ◽  
Kenichi Kobayashi
Keyword(s):  
Total Synthesis ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Cancer Drug ◽  
Drug Candidate ◽  
Cross Coupling Reaction ◽  
Epothilone D ◽  
Anti Cancer ◽  
Northern Segment ◽  
Synthetic Target

Epothilone D, a microtubule-stabilizing macrolide, is an attractive synthetic target molecule as a potential anti-cancer drug candidate. As part of our ongoing synthetic studies of this natural product, this paper describes the synthesis of the thiazole-containing northern segment of epothilone D via an E-selective bromomethylenation and a Ni/Cr-mediated cross-coupling reaction.

Total synthesis of 12,13-desoxyepothilone B (Epothilone D)

2005 ◽  
Vol 33 (2) ◽  
pp. 116-133 ◽  
Author(s):  
Robert L. Broadrup ◽  
Hema M. Sundar ◽  
Charles S. Swindell
Keyword(s):  
Total Synthesis ◽  
Epothilone D

Total synthesis of epothilone D by sixfold ring cleavage of cyclopropanol intermediates

2010 ◽  
Vol 51 (27) ◽  
pp. 3497-3500 ◽  
Author(s):  
Alaksiej L. Hurski ◽  
Oleg G. Kulinkovich
Keyword(s):  
Total Synthesis ◽  
Ring Cleavage ◽  
Epothilone D

ChemInform Abstract: Total Synthesis of Epothilone B, Epothilone D, and cis- and trans-9,10-Dehydroepothilone D.

ChemInform ◽  
2010 ◽  
Vol 32 (38) ◽  
pp. no-no
Author(s):  
James D. White ◽  
Rich G. Carter ◽  
Kurt F. Sundermann ◽  
Markus Wartmann
Keyword(s):  
Total Synthesis ◽  
Epothilone B ◽  
Epothilone D ◽  
Cis And Trans
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