scholarly journals Lithium Diisopropylamide-Mediated Lithiation of 1,4-Difluorobenzene under Nonequilibrium Conditions: Role of Monomer-, Dimer-, and Tetramer-Based Intermediates and Lessons about Rate Limitation

2014 ◽  
Vol 79 (24) ◽  
pp. 11885-11902 ◽  
Author(s):  
Jun Liang ◽  
Alexander C. Hoepker ◽  
Angela M. Bruneau ◽  
Yun Ma ◽  
Lekha Gupta ◽  
...  
Keyword(s):  
Lithium Diisopropylamide ◽  
Nonequilibrium Conditions

scholarly journals 1,4-Addition of Lithium Diisopropylamide to Unsaturated Esters: Role of Rate-Limiting Deaggregation, Autocatalysis, Lithium Chloride Catalysis, and Other Mixed Aggregation Effects

2010 ◽  
Vol 132 (44) ◽  
pp. 15610-15623 ◽  
Author(s):  
Yun Ma ◽  
Alexander C. Hoepker ◽  
Lekha Gupta ◽  
Marc F. Faggin ◽  
David B. Collum
Keyword(s):  
Lithium Chloride ◽  
Lithium Diisopropylamide ◽  
Unsaturated Esters ◽  
Rate Limiting

scholarly journals Regioselective Lithium Diisopropylamide-Mediated Ortholithiation of 1-Chloro-3-(trifluoromethyl)benzene: Role of Autocatalysis, Lithium Chloride Catalysis, and Reversibility

2011 ◽  
Vol 133 (18) ◽  
pp. 7135-7151 ◽  
Author(s):  
Alexander C. Hoepker ◽  
Lekha Gupta ◽  
Yun Ma ◽  
Marc F. Faggin ◽  
David B. Collum
Keyword(s):  
Lithium Chloride ◽  
Lithium Diisopropylamide

Mechanism of Lithium Diisopropylamide-Mediated Ester Deprotonation:  The Role of Disolvated Monomers

1997 ◽  
Vol 119 (20) ◽  
pp. 4765-4766 ◽  
Author(s):  
Xiufeng Sun ◽  
Sarita L. Kenkre ◽  
Julius F. Remenar ◽  
James H. Gilchrist ◽  
David B. Collum
Keyword(s):  
Lithium Diisopropylamide

scholarly journals Lithium Diisopropylamide-Mediated Ortholithiation of 2-Fluoropyridines: Rates, Mechanisms, and the Role of Autocatalysis

2013 ◽  
Vol 78 (9) ◽  
pp. 4214-4230 ◽  
Author(s):  
Lekha Gupta ◽  
Alexander C. Hoepker ◽  
Yun Ma ◽  
Mihai S. Viciu ◽  
Marc F. Faggin ◽  
...  
Keyword(s):  
Lithium Diisopropylamide

CHANGES IN PROTEIN SYNTHESIS PROFILES OF MEGAKARYOCYTES (MK) DURING MATURATION

1987 ◽  
Author(s):  
C W Jackson ◽  
N K Hutson ◽  
S A Steward
Keyword(s):  
Protein Synthesis ◽  
Cell Mass ◽  
Basic Proteins ◽  
Bovine Plasma ◽  
In Vivo Labeling ◽  
Nonequilibrium Conditions ◽  
Acidic Proteins ◽  
Dimensional Electrophoresis

Several key differentiation events occur within the recognizable MK compartment; however, little is known about the macromolecular changes responsible for these events. In this study, protein synthesis profiles of morphologically immature and mature guinea pig MK populations have been analyzed by twodimensional gel electrophoresis after in vivo labeling with 35S-methionine. MK were enriched by a bovine plasma aggregation enrichment procedure (Blood 69:173, 1987) and then fractionated into immature and mature populations based on differences in their respective buoyant densities (Brit. J. Haematol. 64:33, 1986). With this protocol, immature and mature MK populations were obtained in which MK constituted 95% of the cell mass. Ninety percent of the MK in the immature population had basophilic, immature morphology while ≥90% of those in the mature population had acidophilic, mature staining characteristics after Wright's staining. Protease inhibitors were used throughout the isolation procedure. The cells were solubilized and proteins subjected to two-dimensional electrophoresis according to O'Farrell (J. Biol. Chem. 250:4007, 1975). To examine basic proteins, proteins were electrophoresed in the first dimension under nonequilibrium conditions in a pH gradient as described by O'Farrell et al. (Cell 12:1133, 1977). Analyses of fluorograms revealed both qualitative and quantitative differences in synthesis profiles between these two MK populations. Among acidic proteins whose synthesis was readily detected in immature but not mature MK were ones whose MW and pi were respectively: 120K, 6.4; 7OK, 5.9; 70K, 6.9; 65K, 6.8; 55K, 6.2; 55K, 6.0; 53K, 5.8; 53K, 6.5; 52K, 6.7; 50K, 6.8; 41K, 5.5 and 33K, 6.7. Acidic and neutral proteins prominently synthesized in mature but not immature MK were found at MW and PI of: 110K, 5.7; 110K, 5.8 and 80K, 7.2. Basic proteins prominently synthesized in immature but not mature MK were found at MWs of: 110K; 70K; 52K; 48K; 39K and 18K. Basic proteins actively synthesized by mature but not immature MK had MWs of: 83K; 43K and 17K. These findings demonstrate that differences in protein synthesis patterns can be readily detected between immature and mature MK and provide baseline data with which to explore the role of these proteins in MK differentiation

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor

Role of the allergist in diagnosis and management of patients with uveitis

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 167-172 ◽  
Author(s):  
T. E. Van Metre
Keyword(s):  
Diagnosis And Management

The power of norms to sway fused group members

2018 ◽  
Vol 41 ◽  
Author(s):  
Winnifred R. Louis ◽  
Craig McGarty ◽  
Emma F. Thomas ◽  
Catherine E. Amiot ◽  
Fathali M. Moghaddam
Keyword(s):  
Evolutionary Anthropology ◽  
Normative Systems ◽  
Violent Extremism ◽  
Identity Fusion ◽  
Group Members

AbstractWhitehouse adapts insights from evolutionary anthropology to interpret extreme self-sacrifice through the concept of identity fusion. The model neglects the role of normative systems in shaping behaviors, especially in relation to violent extremism. In peaceful groups, increasing fusion will actually decrease extremism. Groups collectively appraise threats and opportunities, actively debate action options, and rarely choose violence toward self or others.

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