Role of the allergist in diagnosis and management of patients with uveitis

Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder associated with rapidly progressing periodontitis leading to premature loss of deciduous and permanent dentition and diffuse palmoplantar keratosis. Immunologic alterations, genetic mutations, and role of bacteria are some aetiologic factors. Patients present with early periodontal destruction, so periodontists play a significant role in diagnosis and management. This paper reports a case of Papillon- Lefevre syndrome with its clinical manifestations and challenges for periodontal management which was diagnosed in dental department.

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Faculty Opinions recommendation of The emerging role of magnetic resonance imaging in the diagnosis and management of pulmonary hypertension.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1136901.593999 ◽

2008 ◽

Author(s):

Keith McNeil

Keyword(s):

Magnetic Resonance Imaging ◽

Pulmonary Hypertension ◽

Magnetic Resonance ◽

Resonance Imaging ◽

Diagnosis And Management

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Role of interferon gamma release assay in the diagnosis and management of Mycobacterium tuberculosis-associated uveitis: a review

BMJ Open Ophthalmology ◽

10.1136/bmjophth-2020-000663 ◽

2021 ◽

Vol 6 (1) ◽

pp. e000663

Author(s):

Samra Rahman ◽

Muhammad Irfan ◽

M A Rehman Siddiqui

Keyword(s):

Interferon Gamma ◽

Interferon Gamma Release Assay ◽

Limited Evidence ◽

Ocular Tuberculosis ◽

Diagnosis And Management ◽

Pubmed Database ◽

Interferon Gamma Release Assays ◽

Infectious Uveitis ◽

Release Assay

Tuberculosis (TB)-associated uveitis is a common cause of infectious uveitis in the developing world. Diagnosis of TB uveitis remains a challenge. The role of interferon gamma release assays (IGRAs) is uncertain. Herein we summarise the available literature on the utility of IGRAs in the diagnosis and management of TB uveitis. We searched PubMed database from 1 August 2010 to 31 July 2020 using the following keywords alone and in combination: ‘interferon-gamma release assay’, ‘QuantiFERON’, ‘T-SPOT.TB’, ‘TB uveitis’, ‘serpiginous like choroiditis’, ‘tuberculoma’, ‘TB vasculitis’, ‘TB panuveitis’ and ‘ocular tuberculosis’. Data from 58 relevant studies were collated. The review is focused on currently marketed versions of IGRA tests: QuantiFERON-TB Gold In-Tube assay, QuantiFERON-TB Gold Plus assay (QFT-Plus) and T-SPOT.TB. We found limited evidence regarding the diagnostic utility of IGRA in patients with uveitis. No study was identified evaluating the newer QFT test—the QFT-Plus—in patients with uveitis. Similarly, there is lack of data directly comparing QFT-Plus with T-SPOT.TB specifically for the diagnosis of TB uveitis.

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