Conjugated Polymer Nanoparticles by Suzuki–Miyaura Cross-Coupling Reactions in an Emulsion at Room Temperature

2014 ◽  
Vol 47 (19) ◽  
pp. 6531-6539 ◽  
Author(s):  
Duangratchaneekorn Muenmart ◽  
Andrew B. Foster ◽  
Alan Harvey ◽  
Ming-Tsz Chen ◽  
Oscar Navarro ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Room Temperature ◽  
Cross Coupling ◽  
Polymer Nanoparticles ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Conjugated Polymer Nanoparticles

ChemInform Abstract: Pd(OAc)2in WERSA: A Novel Green Catalytic System for Suzuki-Miyaura Cross-Coupling Reactions at Room Temperature.

ChemInform ◽  
2015 ◽  
Vol 46 (47) ◽  
pp. no-no
Author(s):  
Preeti Rekha Boruah ◽  
Abdul Aziz Ali ◽  
Mitali Chetia ◽  
Bishwajit Saikia ◽  
Diganta Sarma
Keyword(s):  
Catalytic System ◽  
Room Temperature ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

Protocol for Palladium/N-Heterocyclic Carbene-Catalyzed Suzuki–Miyaura Cross-Coupling of Amides by N–C(O) Activation

Synthesis ◽  
2020 ◽  
Author(s):  
Peng Lei ◽  
Guangchen Li ◽  
Michal Szostak ◽  
Yun Ling ◽  
Jie An ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Room Temperature ◽  
Bond Activation ◽  
Process Development ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Amide Bonds ◽  
Cross Coupling Reactions ◽  
Synthetic Procedure ◽  
Operational Simplicity

AbstractAmides are among the most important and ubiquitous functional groups in organic chemistry and process development. In this Practical Synthetic Procedure, a protocol for the Suzuki–Miyaura cross-coupling of amides by selective N–C(O) bond activation catalyzed by commercially available, air- and moisture-stable palladium/N-heterocyclic carbene (NHC) complexes is described. The procedure described involves [Pd(IPr)(cin)Cl] [IPr = 2,6-(diisopropylphenyl)imidazol-2-ylidene, cin = cinnamyl] at 0.10 mol% at room temperature and is performed on decagram scale. Furthermore, a procedure for the synthesis of amide starting materials is accomplished via selective N-tert-butoxycarbonylation, which is the preferred method over N-acylation. The present protocol carries advantages of operational simplicity, commercial availability of catalysts, and excellent conversions at low catalyst loadings. The method is generally useful for activation of N–C(O) amide bonds in a broad spectrum of amide precursors. The protocol should facilitate the implementation of amide cross-coupling reactions.

Monophosphine Ligands Promote Pd-Catalyzed C–S Cross-Coupling Reactions at Room Temperature with Soluble Bases

2019 ◽  
Author(s):  
Jessica Xu ◽  
Richard Liu ◽  
Charles Yeung ◽  
Stephen L. Buchwald
Keyword(s):  
Transition Metals ◽  
Room Temperature ◽  
Reliable Method ◽  
Cross Coupling ◽  
Phosphine Ligands ◽  
Coupling Reactions ◽  
Late Transition Metals ◽  
Cross Coupling Reactions ◽  
Agricultural Applications ◽  
Late Transition

<div> <p>The Pd-catalyzed cross-coupling of thiols with aromatic electrophiles is a reliable method for the synthesis of aryl thioethers, which are important compounds for pharmaceutical and agricultural applications. Since thiols and thiolates strongly bind late transition metals, previous research has focused on catalysts supported by chelating, bisphosphine ligands, which were considered less likely to be displaced during the course of the reaction. We show that by using monophosphine ligands instead, more effective catalysis can be achieved. Notably, compared to previous methods, this increased reactivity allows for the use of much lower reaction temperature, soluble bases, and base-sensitive substrates. In contrast to conventional wisdom, our mechanistic data suggest that the extent of displacement of phosphine ligands by thiols is, firstly, not correlated with the ligand bulk or thiol nucleophilicity, and secondly, not predictive of the effectiveness of a given ligand in combination with palladium.</p> </div>

ChemInform Abstract: PVC-Supported Palladium Nanoparticles: An Efficient Catalyst for Suzuki Cross-Coupling Reactions at Room Temperature.

ChemInform ◽  
2013 ◽  
Vol 44 (33) ◽  
pp. no-no ◽  
Author(s):  
Mamidi Samarasimhareddy ◽  
Girish Prabhu ◽  
Thimmalapura M. Vishwanatha ◽  
Vommina V. Sureshbabu
Keyword(s):  
Palladium Nanoparticles ◽  
Room Temperature ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Efficient Catalyst ◽  
Cross Coupling Reactions ◽  
Supported Palladium
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