Click Chemistry of an Ethynylarene Iron Complex: Syntheses, Properties, and Redox Chemistry of Cationic Bimetallic and Dendritic Iron-Sandwich Complexes

2014 ◽  
Vol 33 (13) ◽  
pp. 3583-3590 ◽  
Author(s):  
Amalia Rapakousiou ◽  
Yanlan Wang ◽  
Roberto Ciganda ◽  
Jean-Michel Lasnier ◽  
Didier Astruc
Keyword(s):  
Click Chemistry ◽  
Redox Chemistry ◽  
Iron Complex ◽  
Sandwich Complexes

Organotransition-metal metallacarboranes. 25. Redox chemistry and electronic studies of mono- and dinuclear iron(II)-iron(III) sandwich complexes

1992 ◽  
Vol 114 (13) ◽  
pp. 5214-5221 ◽  
Author(s):  
Martin Stephan ◽  
James H. Davis ◽  
Xiangsheng Meng ◽  
Kevin J. Chase ◽  
Jan Hauss ◽  
...  
Keyword(s):  
Redox Chemistry ◽  
Sandwich Complexes ◽  
Dinuclear Iron

The Role of the Interaction between Fe(III) and Cell Surface in the Accumulation of 67Ga by Tumor Cells

1991 ◽  
Vol 30 (06) ◽  
pp. 290-293 ◽  
Author(s):  
P. Maleki ◽  
A. Martinezi ◽  
M. C. Crone-Escanye ◽  
J. Robert ◽  
L. J. Anghileri
Keyword(s):  
Cell Surface ◽  
Tumor Cells ◽  
Ionic Composition ◽  
Iron Complex ◽  
Iron Binding ◽  
Complex Time ◽  
Interaction Product ◽  
Thermodynamic Constant ◽  
Number Of Cells

The study of the interaction between complexed iron and tumor cells in the presence of 67Ga-citrate indicates that a phenomenon of iron-binding related to the thermodynamic constant of stability of the iron complex, and a hydrolysis (or anion penetration) of the interaction product determine the uptake of 67Ga. The effects of various parameters such as ionic composition of the medium, nature of the iron complex, time of incubation and number of cells are discussed.

Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

2019 ◽  
Author(s):  
Qinheng Zheng ◽  
Hongtao Xu ◽  
Hua Wang ◽  
Wen-Ge Han Du ◽  
Nan Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Performance ◽  
Isotopic Exchange ◽  
Tumor Imaging ◽  
Radiochemical Yield ◽  
Exchange Method ◽  
Molar Activity ◽  
Positron Emission ◽  
Sulfur Fluoride

The lack of simple, efficient [<sup>18</sup>F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [<sup>18</sup>F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated <sup>18</sup>F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol<sup>–1</sup>) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [<sup>18</sup>F]fluorosulfate is demonstrated by the <i>in vivo</i> tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

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