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Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1450
Author(s):  
Marco Ruggeri ◽  
Mauro Pavan ◽  
Matteo Soato ◽  
Susi Panfilo ◽  
Carlo Barbera ◽  
...  

Interstitial cystitis (IC) or painful bladder syndrome is a chronic dysfunction due to an inflammatory condition, characterized by bladder pain and urinary frequency. Currently, no gold standard therapy is available since IC does not respond to conventional ones. Given these premises, the aim of this work was the in vitro characterization of biological properties (mucoadhesion and anti-inflammatory activity) of a commercial product (HydealCyst–HydC) based on hyaluronic acid (HA) and the benzyl ester of HA (Hydeal-D®) intended for bladder instillation to restore and/or protect the urothelial layer of glycosamino glycans (GAGs). The in vitro characterization demonstrated that an interaction product is formed between HA and Hydeal-D® that has a role in the rheological behavior and mucoadhesive properties. HA was identified as a key component to form the mucoadhesive joint, while the interaction of HA with Hydeal-D® improved polysaccharide stability and prolonged the activity ex vivo. Moreover, HydC is cytocompatible with urothelial cells (HTB-4) and possesses an anti-inflammatory effect towards these cells by decreasing the secretion of IL-6 and IL-8, which were both increased in patients with IC, and by increasing the secretion of sulfated GAGs. These two findings, along with the resilience properties of the formulation due to mucoadhesion, suggest the active role of HydC in protecting and restoring urothelium homeostasis.


Author(s):  
Sella Nopela ◽  
Rita Sinthia

ABSTRAKPenelitian ini bertujuan untuk mengetahui hubungan antara penyesuaian diri dan rasa empati dengan interaksi sosial pada siswa kelas XI IPS di SMA Negeri1 Argamakmur. Penelitian ini adalah penelitian korelasi dengan instrument angket. Teknik pengumpulan data melalui angket hubungan antara penyesuaian diri dan rasa empati dengan interaksi sosial teknik  korelasi product moment dan korelasi ganda. Hasil yang di peroleh dalam penelitian adalah hubungan yang signifikan antara penyesuaian diri dengan interaksi sosial dengan nilai rx1y 0,512. Adanya hubungan yang signifikan antara penyesuaian diri dengan interaksi sosial f dengan nilai rx2y 0,802 dan adanya hubungan yang signifikan antara penyesuaian diri dan rasa empati dengan interaksi dengan nilai rx1x2y 0.684. Dari hasil penelitian ini dapat disimpulkan bahwa adanya hubungan korelasi yang signifikan antara penyesuaian diri dan rasa empati dengan interaksi pada siswa kelas XI IPS di SMA Negeri 1 Argamakmur dengan tingkat hubungan kuat.Kata kunci:  Penyesuaian Diri, Rasa Empati, Interaksi Sosial CORRELATION OF  ADJUSTMENT AND EMPAHTY TO SOCIAL INTERACTIONS OF TWO GRADE STUDENTS MAJORINGIN SOCIAL PROGRAMAT SMANEGERI 1 ARGAMAKMUR  ABSTRACTThis study aims to study the relationship between self and empathy with social interaction in social studies class XI students at SMA Negeri 1 Argamakmur. This study is a correlation study with a questionnaire instrument. Data collection techniques through a questionnaire the relationship between adjustment and empathy with social interaction product moment correlation techniques and multiple correlation. The results obtained in the study are significant relationships between adjustment and social interaction with a value of rx1y 0.512. There is a significant relationship between adjustment and social interaction f with a value of rx2y 0.802 and a significant relationship between adjustment and a sense of empathy with interactions with a value of rx1x2y 0.684. From the results of this study it can be concluded that there is a significant correlation between the adjustment and empathy with the interaction in students of class XI IPS in SMA Negeri 1 Argamakmur with a strong relationship levelKey Word:  Adjustment, Empathy, Social Interactions


This study aims to analyze and test the hypothesis of the effect of co-creation on the performance of the creative industries in Indonesia. Co-creation measurements with Across Interaction, Product Options, Access and Price Experience, while Firm Performance (Financial, Customer, Internal Business Process, Learning and Growth Perspective). The study method uses explanatory survey with data collection techniques using a questionnaire. The population in this study, SMEs engaged in the creative industries in West Java, Indonesia with a total of 1,571. With slovin sampling technique obtained 252 respondents. The collected data is then analyzed using the Structural Equation Model (SEM). The results of the study show that co-creation has a significant effect on the performance of creative industry SMEs in Indonesia, and the proposed hypothesis is accepted. This finding implies that to win the competition, SMEs must be able to improve their performance through the ability to innovate. Besides that This study implies to improve the performance of creative industry, it is necessary to improve the co-creation process such as increasing across-interactions, increasing the diversity of product options, and facilitating access to information on products.


2019 ◽  
Vol 195 (5) ◽  
pp. 421-428
Author(s):  
Victoria A. Ivolgina ◽  
Margarita S. Chernov’yants ◽  
Leonid D. Popov ◽  
Vitaliy V. Suslonov ◽  
Natalya A. Avtushenko ◽  
...  

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 533 ◽  
Author(s):  
Ana Borrego-Sánchez ◽  
Rita Sánchez-Espejo ◽  
Beatrice Albertini ◽  
Nadia Passerini ◽  
Pilar Cerezo ◽  
...  

Calcium carbonate is an abundant mineral with several advantages to be a successful carrier to improve oral bioavailability of poorly water-soluble drugs, such as praziquantel. Praziquantel is an antiparasitic drug classified in group II of the Biopharmaceutical Classification System hence characterized by high-permeability and low-solubility. Therefore, the dissolution rate is the limiting factor for the gastrointestinal absorption that contributes to the low bioavailability. Consequently, the therapeutic dose of the praziquantel must be high and big tablets and capsules are required, which are difficult to swallow, especially for pediatric and elderly patients. Mixtures of praziquantel and calcium carbonate using solid-solid physical mixtures and solid dispersions were prepared and characterized using several techniques (X-ray diffraction differential scanning calorimetry, thermogravimetric analysis, scanning electron microscopy, laser diffraction, Fourier transform infrared and Raman spectroscopies). Solubility of these formulations evidenced that the solubility of praziquantel-calcium carbonate interaction product increased in physiological media. In vitro dissolution tests showed that the interaction product increased the dissolution rate of the drug in acidic medium. Theoretical models were studied to understand this experimental behavior. Cytotoxicity and cell cycle studies were performed, showing that praziquantel-calcium carbonate physical mixture and interaction product were biocompatible with the HTC116 cells, because it did not produce a decrease in cell viability or alterations in the cell cycle.


2019 ◽  
Vol 56 (9-10) ◽  
pp. 902-914 ◽  
Author(s):  
Toru Kitagaki ◽  
Hirotomo Ikeuchi ◽  
Kimihiko Yano ◽  
Laurent Brissonneau ◽  
Brigitte Tormos ◽  
...  

2018 ◽  
Vol 930 ◽  
pp. 552-555
Author(s):  
Josy Anteveli Osajima ◽  
Edson Cavalcanti da Silva Filho ◽  
Norel H. Belhouchat ◽  
Esperanza C. Gil ◽  
Cesar A.V. Iborra

The resistance of some compounds to conventional treatments engenders the search for alternative methods, such as photo-oxidation. Antibiotics and photo-producers are found in the environment, indicating that these compounds are persistent. This work had as its goal to investigate the photo-oxidation of the antibiotic named tetracycline hydrochloride adsorbed in montmorilloniteclay (VHS) and into aqueous suspension. In order to irradiate the interaction products 0,03g were weighed and put in a petri dish to be collected on pre-determined times. The extraction of the drug was made by adding 10 mL of distilled water and put on the ultrasound for 2 hours. The suspensions were prepared by using 200 mL of the concentration from 25mgL-1of tetracycline in 1gL-1g of clay in a borosilicate reactor. This system was stirred in the dark during 1 hour in order to achieve its balance. The samples were radiated by using an Ultra-Vitalux UV lamp, with 300 W for 2 hours. The kinetics were followed through UV-Vis spectroscopy, monitored in 359 nm, in the maximum wavelength of the drug. The suspensions showed a degradation twice as fast when compared to the interaction product, for the rate of degradation of this system was 24%. This decrease on the concentration may have been caused by the hydroxyl radicals generated by the photolysis of the iron hydroxide II. Hence, one concludes that in the case of the system in suspension it was more effective to the photo-oxidation of this antibiotic. Although, there is the need for increasing the exposure time of the interaction product in order to verify possible structural changes of this system by DRX.


2014 ◽  
Vol 887-888 ◽  
pp. 467-470
Author(s):  
Si Si Zhu ◽  
Jin Zhu Zhang ◽  
Wei Yu Yang

In this study, a certain amount of Cerium and Arsenic were closed in the barrel-shaped cylinder machined by H08 steel, heated to 1173 K for 50 h, and the interaction among the cerium, arsenic and iron in the barrel-shaped cylinder was studied by X-ray diffraction, optical microscopy and electronic probe microscopy analysis. The result shows that the gray phase is the ternary compound Ce12Fe57.5As41, and the ternary compound Ce12Fe57.5As41 is the main interaction product when the atomic ratio of Ce to As is 1:3. The eutectic compound Fe2As can be precipitated from ferrite with the temperature decreasing.


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