Process Research on a Phenoxybutyric Acid LTB4 Receptor Antagonist. Efficient Kilogram-Scale Synthesis of a 3,5-Bisarylphenol Core

2012 ◽  
Vol 17 (1) ◽  
pp. 114-119 ◽  
Author(s):  
Lianhe Shu ◽  
Ping Wang ◽  
Roumen Radinov ◽  
Romyr Dominique ◽  
James Wright ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Process Research ◽  
Ltb4 Receptor

The guinea pig as a suitable species for the characterization of the LTB4 receptor antagonist ZK 158252

1998 ◽  
Vol 16 ◽  
pp. S211
Author(s):  
Claudia Giesen ◽  
Bernd Buchmann ◽  
Roland Ekerdt ◽  
Wolfgang Fröhlich ◽  
Josef Heindl ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Receptor Antagonist ◽  
Ltb4 Receptor

Process Research for (+)-Ambrisentan, an Endothelin-A Receptor Antagonist

2018 ◽  
Vol 22 (9) ◽  
pp. 1200-1207 ◽  
Author(s):  
Wei-Dong Feng ◽  
Song-Ming Zhuo ◽  
Jun Yu ◽  
Chuan-Meng Zhao ◽  
Fu-Li Zhang
Keyword(s):  
Receptor Antagonist ◽  
Process Research ◽  
Endothelin A Receptor ◽  
Endothelin A

Tc-99m-labeled Leukotriene-B4 (LTB4) receptor antagonist RP517 for scintigraphic imaging of infection

2000 ◽  
Vol 21 (6) ◽  
pp. 585-586
Author(s):  
A. H. Brouwers ◽  
P. Laverman ◽  
O. C. Boerman ◽  
W. J.G. Oyen ◽  
J. A. Barrett ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Leukotriene B4 ◽  
Scintigraphic Imaging ◽  
Imaging Of Infection ◽  
Ltb4 Receptor

Inhibition of antigen-induced arthritis in guinea pigs by a selective LTB4 receptor antagonist LY293111Na

2002 ◽  
Vol 51 (11) ◽  
pp. 541-550 ◽  
Author(s):  
K. Kuwabara ◽  
H. Jyoyama ◽  
J. H. Fleisch ◽  
Y. Hori
Keyword(s):  
Receptor Antagonist ◽  
Guinea Pigs ◽  
Ltb4 Receptor

scholarly journals The Leukotriene B4 Receptor Antagonist ONO-4057 Inhibits Nephrotoxic Serum Nephritis in WKY Rats

1999 ◽  
Vol 10 (2) ◽  
pp. 264-270
Author(s):  
SATORU SUZUKI ◽  
TAKESHI KURODA ◽  
JUN-ICHIROU KAZAMA ◽  
NAOFUMI IMAI ◽  
HIDEKI KIMURA ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Crescentic Glomerulonephritis ◽  
Leukotriene B4 ◽  
Dependent Manner ◽  
Wistar Kyoto ◽  
Leukotriene B4 Receptor ◽  
Phosphate Buffered Saline ◽  
Dose Dependent ◽  
Ltb4 Receptor

Abstract. To evaluate the role of leukotriene B4 (LTB4) in glomerulonephritis, this study was conducted to examine whether ONO-4057, an LTB4 receptor antagonist, moderated nephritis caused by the injection of nephrotoxic serum (NTS) into Wistar-Kyoto rats. Rats were given intraperitoneal injections of ONO-4057 or phosphate-buffered saline 24 h before the injection of NTS. These rats subsequently received equal doses of ONO-4057 or phosphate-buffered saline 3 h and 1, 2, 3, 4, 5, and 6 d later. Compared with the control groups, ONO-4057 treatment significantly reduced proteinuria and hematuria, suppressed the glomerular accumulation of monocytes/macrophages, and reduced the formation of crescentic glomeruli in a dose-dependent manner. These results suggest that LTB4 is responsible for the crescentic formations and renal dysfunction associated with NTS nephritis. The LTB4 receptor antagonist ONO-4057 may thus be beneficial in the treatment of crescentic glomerulonephritis.

Synthesis and LTB4 receptor antagonist activities of the naturally occurring LTB4 receptor antagonist leucettamine A and related analogs

1993 ◽  
Vol 36 (22) ◽  
pp. 3333-3340 ◽  
Author(s):  
Jeffrey C. Boehm ◽  
John G. Gleason ◽  
Israil Pendrak ◽  
Henry M. Sarau ◽  
Dulcie B. Schmidt ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Naturally Occurring ◽  
Ltb4 Receptor

Process Research and Scale-up of a Commercialisable Route to Maraviroc (UK-427,857), a CCR-5 Receptor Antagonist

2008 ◽  
Vol 12 (6) ◽  
pp. 1104-1113 ◽  
Author(s):  
Jens Åhman ◽  
Melissa Birch ◽  
Sarah J. Haycock-Lewandowski ◽  
James, Long ◽  
Alexander Wilder
Keyword(s):  
Receptor Antagonist ◽  
Scale Up ◽  
Process Research
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