Evaluation of Felbamate and Other Antiepileptic Drug Toxicity Potential Based on Hepatic Protein Covalent Binding and Gene Expression

2007 ◽  
Vol 20 (4) ◽  
pp. 600-608 ◽  
Author(s):  
Angelique M. Leone ◽  
L. M. Kao ◽  
Michael K. McMillian ◽  
Alex Y. Nie ◽  
James B. Parker ◽  
...  
Keyword(s):  
Gene Expression ◽  
Antiepileptic Drug ◽  
Drug Toxicity ◽  
Covalent Binding ◽  
Toxicity Potential ◽  
Protein Covalent

A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

2009 ◽  
Vol 37 (9) ◽  
pp. 1970-1977 ◽  
Author(s):  
Shintaro Nakayama ◽  
Ryo Atsumi ◽  
Hideo Takakusa ◽  
Yoshimasa Kobayashi ◽  
Atsushi Kurihara ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Classification System ◽  
Drug Toxicity ◽  
Covalent Binding ◽  
Daily Dose ◽  
Idiosyncratic Drug Toxicity

scholarly journals Correction: Hepatic gene expression explains primary drug toxicity in bipolar disorder

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anna Maria Birkl-Toeglhofer ◽  
Christoph Birkl ◽  
Ida Cirila Llenos ◽  
Serge Weis ◽  
Johannes Haybaeck
Keyword(s):  
Gene Expression ◽  
Bipolar Disorder ◽  
Drug Toxicity ◽  
Hepatic Gene Expression ◽  
Primary Drug

Evidence for cytochrome P4501A2-mediated protein covalent binding of thiabendazole and for its passive intestinal transport: use of human and rabbit derived cells

2000 ◽  
Vol 127 (2) ◽  
pp. 109-124 ◽  
Author(s):  
Myriam Coulet ◽  
Claudine Eeckhoutte ◽  
Gilberte Larrieu ◽  
Jean-François Sutra ◽  
Michel Alvinerie ◽  
...  
Keyword(s):  
Covalent Binding ◽  
Intestinal Transport ◽  
Cytochrome P4501a2 ◽  
Protein Covalent

METABOLISM, PHARMACOKINETICS, AND PROTEIN COVALENT BINDING OF RADIOLABELED MAXIPOST (BMS-204352) IN HUMANS

2004 ◽  
Vol 33 (1) ◽  
pp. 83-93 ◽  
Author(s):  
Donglu Zhang ◽  
Rajesh Krishna ◽  
Lifei Wang ◽  
Jianing Zeng ◽  
James Mitroka ◽  
...  
Keyword(s):  
Covalent Binding ◽  
Protein Covalent
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