Base Sequence-Dependent Bends in Site-Specific Benzo[a]pyrene Diol Epoxide-Modified Oligonucleotide Duplexes

1996 ◽  
Vol 9 (1) ◽  
pp. 255-261 ◽  
Author(s):  
Tongming Liu ◽  
Jing Xu ◽  
Hong Tsao ◽  
Bin Li ◽  
Rong Xu ◽  
...  
Keyword(s):  
Base Sequence ◽  
Site Specific ◽  
Diol Epoxide ◽  
Sequence Dependent ◽  
Modified Oligonucleotide

Sequence Context Effects on Mutational Properties of cis-Opened Benzo[c]phenanthrene Diol Epoxide−Deoxyadenosine Adducts in Site-Specific Mutation Studies†

Biochemistry ◽  
1999 ◽  
Vol 38 (3) ◽  
pp. 1144-1152 ◽  
Author(s):  
Ingrid Pontén ◽  
Jane M. Sayer ◽  
Anthony S. Pilcher ◽  
Haruhiko Yagi ◽  
Subodh Kumar ◽  
...  
Keyword(s):  
Context Effects ◽  
Sequence Context ◽  
Site Specific ◽  
Specific Mutation ◽  
Diol Epoxide ◽  
Deoxyadenosine Adducts

scholarly journals Human Cytomegalovirus Mutant with Sequence-Dependent Resistance to the Phosphorothioate Oligonucleotide Fomivirsen (ISIS 2922)

1998 ◽  
Vol 42 (4) ◽  
pp. 971-973 ◽  
Author(s):  
Gilbert B. Mulamba ◽  
André Hu ◽  
Raana F. Azad ◽  
Kevin P. Anderson ◽  
Donald M. Coen
Keyword(s):  
Human Cytomegalovirus ◽  
Antisense Oligonucleotide ◽  
Cross Resistance ◽  
Base Sequence ◽  
Target Sequence ◽  
Phosphorothioate Oligonucleotide ◽  
Sequence Dependent ◽  
Unrelated Sequence

ABSTRACT A human cytomegalovirus mutant that was isolated for resistance (10-fold) to the antisense oligonucleotide fomivirsen (ISIS 2922) exhibited cross-resistance to a modified derivative of fomivirsen with an identical base sequence but little or no resistance to an oligonucleotide with an unrelated sequence. No changes in the mutant’s DNA corresponding to the fomivirsen target sequence were found.

Site-Specific Benzo[a]pyrene Diol Epoxide-DNA Adducts Inhibit Transcription Elongation by Bacteriophage T7 RNA Polymerase

Biochemistry ◽  
1994 ◽  
Vol 33 (3) ◽  
pp. 780-787 ◽  
Author(s):  
Deok Joon Choi ◽  
Deirdre J. Marino-Alessandri ◽  
Nicholas E. Geacintov ◽  
David A. Scicchitano
Keyword(s):  
Rna Polymerase ◽  
Dna Adducts ◽  
Transcription Elongation ◽  
T7 Rna Polymerase ◽  
Bacteriophage T7 ◽  
Site Specific ◽  
Diol Epoxide

Role of Base Sequence Context in Conformational Equilibria and Nucleotide Excision Repair of Benzo[a]pyrene Diol Epoxide−Adenine Adducts†

Biochemistry ◽  
2003 ◽  
Vol 42 (8) ◽  
pp. 2339-2354 ◽  
Author(s):  
Shixiang Yan ◽  
Min Wu ◽  
Tonko Buterin ◽  
Hanspeter Naegeli ◽  
Nicholas E. Geacintov ◽  
...  
Keyword(s):  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Base Sequence ◽  
Sequence Context ◽  
Diol Epoxide ◽  
Nucleotide Excision ◽  
Conformational Equilibria ◽  
Adenine Adducts

scholarly journals Site-specific adducts derived from the binding of anti-5-methylchrysene diol epoxide enantiomers to DNA: Synthesis and characteristics

1996 ◽  
Vol 17 (9) ◽  
pp. 2035-2042 ◽  
Author(s):  
Rong Xu ◽  
Sulatha Dwarakanath ◽  
Monique Cosman ◽  
Shantu Amin ◽  
Nicholas E. Geacintov
Keyword(s):  
Dna Synthesis ◽  
Site Specific ◽  
Diol Epoxide

Sequence-dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

FEBS Letters ◽  
1987 ◽  
Vol 215 (2) ◽  
pp. 327-330 ◽  
Author(s):  
Hideo Inoue ◽  
Yoji Hayase ◽  
Shigenori Iwai ◽  
Eiko Ohtsuka
Keyword(s):  
Rnase H ◽  
Sequence Dependent ◽  
Modified Oligonucleotide ◽  
Hydrolysis Of

Impact of Site-Specific Benzo[a]Pyrene Diol Epoxide-dG Lesions at or near Single/Double-Strand DNA Junctions on DNA Bending

2000 ◽  
Vol 21 (1-4) ◽  
pp. 1-10
Author(s):  
Hong Tsao ◽  
Olga Rechkoblit ◽  
Shantu Amin ◽  
Nicholas E. Geacintov
Keyword(s):  
Dna Bending ◽  
Site Specific ◽  
Dna Junctions ◽  
Diol Epoxide ◽  
Double Strand Dna
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