Sequence Context Effects on Mutational Properties of cis-Opened Benzo[c]phenanthrene Diol Epoxide−Deoxyadenosine Adducts in Site-Specific Mutation Studies†

Biochemistry ◽  
1999 ◽  
Vol 38 (3) ◽  
pp. 1144-1152 ◽  
Author(s):  
Ingrid Pontén ◽  
Jane M. Sayer ◽  
Anthony S. Pilcher ◽  
Haruhiko Yagi ◽  
Subodh Kumar ◽  
...  
Keyword(s):  
Context Effects ◽  
Sequence Context ◽  
Site Specific ◽  
Specific Mutation ◽  
Diol Epoxide ◽  
Deoxyadenosine Adducts

Sequence Context Profoundly Influences the Mutagenic Potency of Trans-Opened Benzo[a]pyrene 7,8-Diol 9,10-Epoxide−Purine Nucleoside Adducts in Site-Specific Mutation Studies†

Biochemistry ◽  
1998 ◽  
Vol 37 (25) ◽  
pp. 9127-9137 ◽  
Author(s):  
John E. Page ◽  
Barbara Zajc ◽  
Toshinari Oh-hara ◽  
Mahesh K. Lakshman ◽  
Jane M. Sayer ◽  
...  
Keyword(s):  
Purine Nucleoside ◽  
Sequence Context ◽  
Site Specific ◽  
Specific Mutation ◽  
Nucleoside Adducts

scholarly journals Phase Variation of Campylobacter jejuni 81-176 Lipooligosaccharide Affects Ganglioside Mimicry and Invasiveness In Vitro

2002 ◽  
Vol 70 (2) ◽  
pp. 787-793 ◽  
Author(s):  
Patricia Guerry ◽  
Christine M. Szymanski ◽  
Martina M. Prendergast ◽  
Thomas E. Hickey ◽  
Cheryl P. Ewing ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Phase Variation ◽  
Outer Core ◽  
Gene Encoding ◽  
Site Specific ◽  
Reading Frame ◽  
Specific Mutation ◽  
Normal Human ◽  
A Site

ABSTRACT The outer cores of the lipooligosaccharides (LOS) of many strains of Campylobacter jejuni mimic human gangliosides in structure. A population of cells of C. jejuni strain 81-176 produced a mixture of LOS cores which consisted primarily of structures mimicking GM2 and GM3 gangliosides, with minor amounts of structures mimicking GD1b and GD2. Genetic analyses of genes involved in the biosynthesis of the outer core of C. jejuni 81-176 revealed the presence of a homopolymeric tract of G residues within a gene encoding CgtA, an N-acetylgalactosaminyltransferase. Variation in the number of G residues within cgtA affected the length of the open reading frame, and these changes in cgtA corresponded to a change in LOS structure from GM2 to GM3 ganglioside mimicry. Site-specific mutation of cgtA in 81-176 resulted in a major LOS core structure that lacked GalNAc and resembled GM3 ganglioside. Compared to wild-type 81-176, the cgtA mutant showed a significant increase in invasion of INT407 cells. In comparison, a site-specific mutation of the neuC1 gene resulted in the loss of sialic acid in the LOS core and reduced resistance to normal human serum but had no affect on invasion of INT407 cells.

scholarly journals DNA Oligomers Containing Site-Specific and Stereospecific Exocyclic Deoxyadenosine Adducts of 1,2,3,4-Diepoxybutane: Synthesis, Characterization, and Effects on DNA Structure

2010 ◽  
Vol 23 (10) ◽  
pp. 1556-1567 ◽  
Author(s):  
Uthpala Seneviratne ◽  
Sergey Antsypovich ◽  
Danae Quirk Dorr ◽  
Thakshila Dissanayake ◽  
Srikanth Kotapati ◽  
...  
Keyword(s):  
Dna Structure ◽  
Dna Oligomers ◽  
Site Specific ◽  
Deoxyadenosine Adducts

Base Sequence-Dependent Bends in Site-Specific Benzo[a]pyrene Diol Epoxide-Modified Oligonucleotide Duplexes

1996 ◽  
Vol 9 (1) ◽  
pp. 255-261 ◽  
Author(s):  
Tongming Liu ◽  
Jing Xu ◽  
Hong Tsao ◽  
Bin Li ◽  
Rong Xu ◽  
...  
Keyword(s):  
Base Sequence ◽  
Site Specific ◽  
Diol Epoxide ◽  
Sequence Dependent ◽  
Modified Oligonucleotide

Site-Specific Benzo[a]pyrene Diol Epoxide-DNA Adducts Inhibit Transcription Elongation by Bacteriophage T7 RNA Polymerase

Biochemistry ◽  
1994 ◽  
Vol 33 (3) ◽  
pp. 780-787 ◽  
Author(s):  
Deok Joon Choi ◽  
Deirdre J. Marino-Alessandri ◽  
Nicholas E. Geacintov ◽  
David A. Scicchitano
Keyword(s):  
Rna Polymerase ◽  
Dna Adducts ◽  
Transcription Elongation ◽  
T7 Rna Polymerase ◽  
Bacteriophage T7 ◽  
Site Specific ◽  
Diol Epoxide

scholarly journals Site Specific Mutation of the Zic2 Locus by Microinjection of TALEN mRNA in Mouse CD1, C3H and C57BL/6J Oocytes

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e60216 ◽  
Author(s):  
Benjamin Davies ◽  
Graham Davies ◽  
Christopher Preece ◽  
Rathi Puliyadi ◽  
Dorota Szumska ◽  
...  
Keyword(s):  
Site Specific ◽  
Specific Mutation

scholarly journals Distant Neighbor Base Sequence Context Effects in Human Nucleotide Excision Repair of a Benzo[a]pyrene-derived DNA Lesion

2010 ◽  
Vol 399 (3) ◽  
pp. 397-409 ◽  
Author(s):  
Yuqin Cai ◽  
Konstantin Kropachev ◽  
Rong Xu ◽  
Yijin Tang ◽  
Marina Kolbanovskii ◽  
...  
Keyword(s):  
Nucleotide Excision Repair ◽  
Context Effects ◽  
Excision Repair ◽  
Base Sequence ◽  
Sequence Context ◽  
Dna Lesion ◽  
Nucleotide Excision ◽  
Distant Neighbor
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