The contractile apparatus as a target for drugs against heart failure: Interaction of levosimendan, a calcium sensitiser, with cardiac troponin c

2004 ◽  
Vol 266 (1/2) ◽  
pp. 87-107 ◽  
Author(s):  
Tia Sorsa ◽  
Piero Pollesello ◽  
R. John Solaro
Keyword(s):  
Heart Failure ◽  
Cardiac Troponin ◽  
Troponin C ◽  
Contractile Apparatus ◽  
Cardiac Troponin C ◽  
Calcium Sensitiser ◽  
Failure Interaction

scholarly journals Engineering Cardiac Troponin C: Potential Therapeutic for Heart Failure

2015 ◽  
Vol 108 (2) ◽  
pp. 596a
Author(s):  
Vikram Shettigar ◽  
Sean C. Little ◽  
Bo Zhang ◽  
Jianchao Zhang ◽  
Steve Roof ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Troponin ◽  
Troponin C ◽  
Cardiac Troponin C

Changes in cardiac troponins with gestational age explain changes in cardiac muscle contractility in the sheep fetus

2011 ◽  
Vol 111 (1) ◽  
pp. 236-243 ◽  
Author(s):  
Giuseppe Saverio Posterino ◽  
Stacey Leanne Dunn ◽  
Kimberley Jae Botting ◽  
William Wang ◽  
Sheridan Gentili ◽  
...  
Keyword(s):  
Protein Expression ◽  
Gestational Age ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin C ◽  
Cardiac Troponin I ◽  
Late Gestation ◽  
Contractile Apparatus ◽  
C Protein ◽  
Cardiac Troponin C

The development of the adult cardiac troponin complex in conjunction with changes in cardiac function and cardiomyocyte binucleation has not been systematically characterized during fetal life in a species where maturation of the cardiomyocytes occurs prenatally as it does in the human. The aim of this study was to correlate the expression of each of the major adult troponin isoforms (T, I, and C) during late gestation (term of 150 days) to changes in both Ca2+ sensitivity and maximum Ca2+-activated force of the contractile apparatus and the maturation of cardiomyocytes. The percentage of mononucleated cardiomyocytes in the right ventricle decreased with gestational age to 46% by 137–142 days of gestation. The length of binucleated cardiomyocytes did not change with gestational age, but the length of binucleated cardiomyocytes relative to heart weight decreased with gestational age. There was no change in the expression of adult cardiac troponin T with increasing gestation. The contractile apparatus was significantly more sensitive to Ca2+ at 90 days compared with either 132 or 139 days of gestation, consistent with an ∼30% increase in the expression of adult cardiac troponin I between 90 and 110 days of gestation. Maximum Ca2+-activated force significantly increased from 90 days compared with 130 days consistent with an increase of ∼40% in cardiac troponin C protein expression. These data show that increased adult cardiac troponin I and C protein expression across late gestation is consistent with reduced Ca2+ sensitivity and increased maximum Ca2+-activated force. Furthermore, changes in cardiac troponin C, not I, protein expression track with the timing of cardiomyocyte binucleation.

scholarly journals Mutation of the high affinity calcium binding sites in cardiac troponin C.

1992 ◽  
Vol 267 (2) ◽  
pp. 825-831 ◽  
Author(s):  
J C Negele ◽  
D G Dotson ◽  
W Liu ◽  
H L Sweeney ◽  
J A Putkey
Keyword(s):  
Binding Sites ◽  
Calcium Binding ◽  
Cardiac Troponin ◽  
Troponin C ◽  
High Affinity ◽  
Cardiac Troponin C ◽  
Calcium Binding Sites
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