Chronic pain is a highly prevalent condition that causes substantial impairment in many domains of life. Recent advances in pain research have elucidated the many biological, psychological, and social factors that can contribute to and impact the subjective experience of pain. In addition to treating patients using medications to manage pain, psychological treatments have now been developed and tested and found to significantly improve the severity of pain and the negative mood that often accompanies pain, as well as disability and impairment. Cognitive behavioral approaches are now considered the “gold standard” psychological treatment for pain. To maximize their efficacy, however, these treatments are not implemented rigidly; rather, they are tailored to the particular needs of the patient. This chapter covers the essential treatment components for pain and offers therapists ideas for effectively tailoring treatment to individual patients, so that pain treatment can be implemented flexibly, but with fidelity.