Renal excretion of uric acid: Alterations during stressful underwater demolition team training.

1971 ◽  
Author(s):  
Leonard M. Zir ◽  
Robert T. Rubin ◽  
Richard H. Rahe ◽  
Ransom J. Arthur
Keyword(s):  
Uric Acid ◽  
Renal Excretion ◽  
Team Training

Renal excretion of uric acid. Alterations during stressful underwater demolition-team training

1973 ◽  
Vol 132 (6) ◽  
pp. 808-812 ◽  
Author(s):  
L. M. Zir
Keyword(s):  
Uric Acid ◽  
Renal Excretion ◽  
Team Training

scholarly journals Renal excretion of uric acid in normal and gouty man

1965 ◽  
Vol 8 (4) ◽  
pp. 665-670 ◽  
Author(s):  
Alexander B. Gutman
Keyword(s):  
Uric Acid ◽  
Renal Excretion

Renal Excretion of Uric Acid

1973 ◽  
Vol 132 (6) ◽  
pp. 808 ◽  
Author(s):  
Leonard M. Zir
Keyword(s):  
Uric Acid ◽  
Renal Excretion

Reduced renal excretion of uric acid in the Hirsutism-skeletal dysplasia-mental retardation syndrome

1994 ◽  
Vol 51 (2) ◽  
pp. 165-167
Author(s):  
Oskar Oster ◽  
Hans-Rudolf Wiedemann ◽  
I. A. Duley ◽  
H. A. Simmonds ◽  
M. B. McBride
Keyword(s):  
Uric Acid ◽  
Mental Retardation ◽  
Skeletal Dysplasia ◽  
Renal Excretion

Renal excretion of allantoin in rats: a micropuncture and clearance study

1977 ◽  
Vol 233 (5) ◽  
pp. F373-F381 ◽  
Author(s):  
J. P. Briggs ◽  
M. F. Levitt ◽  
R. G. Abramson
Keyword(s):  
Uric Acid ◽  
Renal Excretion ◽  
Rat Kidney ◽  
Chromatographic Technique ◽  
Experimental Conditions ◽  
Clearance Studies ◽  
Fluid Collections ◽  
And Control ◽  
Clearance Study ◽  
Column Chromatographic

Free-flow micropuncture and clearance studies were performed to evaluate the transport of allantoin inthe rat kidney. Inn all studies [2-14C]uric acid and [methoxy-3H]inulin were administered. With a two-step column chromatographic technique, radiolabeled uric acid and allantoin were separated in plasma, urine, and tubular fluid, and the [2-14C]allantoin concentration was determined. Tubular fluid collections were obtained under hydropenic and control coneated animals in the control and volume-expanded states. Clearance data were obtained in oxonic acid-treated animals under the same experimental conditions. These studies indicate that allantoin is not bound to plasma protein and is, therefore, freely filterable. Neither net reabsorption nor net secretion of allantoin was evident along the length of the nephron. The bubular handling of allantoin was demonstrated to be dissociated from that of uric acid in all experimental states. No significant intrarenal production of allantoin from uric acid was observed.

The Effects of Ginsenosides and Anserine on the Up-Regulation of Renal Aquaporins 1–4 in Hyperuricemic Mice

2019 ◽  
Vol 47 (05) ◽  
pp. 1133-1147
Author(s):  
Yalin Zhang ◽  
Han Su ◽  
Juan Zhang ◽  
Juan Kong
Keyword(s):  
Metabolic Disease ◽  
Renal Function ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Clearance Rate ◽  
Renal Excretion ◽  
Synergistic Effects ◽  
Acid Excretion ◽  
Urea Nitrogen ◽  
Uric Acid Excretion

Hyperuricemia is a metabolic disease of the kidney that results in decreased uric acid excretion. Here, we aimed to investigate the effects of ginsenosides and anserine on hyperuricemia and the expression of aquaporin (AQP) 1–4, which are indicators of renal excretion. Ginsenosides and anserine were administered separately or together after the establishment of hyperuricemia with adenine in BALB/c mice. Renal function indexes such as serum uric acid, creatinine, and urea nitrogen were measured in each group of mice, and the expression of AQP1–4 in renal tissues was detected. Serum uric acid and urea nitrogen were decreased in the ginsenoside and the anserine +UA groups. Meanwhile, the uric acid excretion and clearance rate were clearly increased in the co-treatment +UA group ([Formula: see text].05). Moreover, ginsenosides or anserine ginsenosides or anserine alone and treatment with both increased the expression of AQP1–4; however, the synergistic effects were more significantly enhanced ([Formula: see text].01). We provide the first reported evidence that ginsenosides and anserine have synergistic effects on uric acid excretion. The improvement in renal function in hyperuricemic mice after treatment with ginsenosides and anserine may result from up-regulation of AQP1–4 expressions.

scholarly journals Decreased Renal Excretion of Uric Acid Following Diuretic Administration in Rats

1984 ◽  
Vol 34 (4) ◽  
pp. 389-396
Author(s):  
Kazumi IWAKI ◽  
Yukio YONETANI
Keyword(s):  
Uric Acid ◽  
Renal Excretion

scholarly journals Hyperuricemia and Cardiovascular Diseases Clinical and paraclinical correlations

2019 ◽  
Vol 70 (3) ◽  
pp. 1045-1046 ◽  
Author(s):  
Delia Timofte ◽  
Adina Mandita ◽  
Andra-Elena Balcangiu-Stroescu ◽  
Daniela Balan ◽  
Laura Raducu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cardiovascular Diseases ◽  
National Health ◽  
Renal Excretion ◽  
Nutrition Examination Survey ◽  
Purine Nucleotides ◽  
Target Value ◽  
The Past ◽  
Health And Nutrition

Uric acid is the end product of endogenous and exogenous of purine nucleotides catabolism, the serum concentrate being determined by the production and elimination ratio. Elimination is achieved through renal excretion � two thirds- and the rest through digestive way. In most studies, hyperuricemia is defined as ] 7 mg/dL uric acid in men and ] 6 mg/dL in women, and the guides for gout treatment recommend target value of uric acid under 6 mg/dL [1]. According to the NHANES ( National Health and Nutrition Examination Survey) register, the prevalence of hyperuricemia has increased by 3.2% and that of gout by 1.2% during the past twenty years[1].

Effect of nonsteroidal anti-inflammatory drugs on the renal excretion of uric acid

1983 ◽  
Vol 2 (3) ◽  
pp. 233-236 ◽  
Author(s):  
S. Tiitinen ◽  
M Nissilä ◽  
H. M. Ruutsalo ◽  
H. Isomäki
Keyword(s):  
Uric Acid ◽  
Renal Excretion ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Renal excretion of uric acid in the rat: a micropuncture and microperfusion study

1976 ◽  
Vol 230 (3) ◽  
pp. 768-776 ◽  
Author(s):  
F Roch-Ramel ◽  
F Diezi-Chomety ◽  
D De Rougemont ◽  
M Tellier ◽  
J Widmer ◽  
...  
Keyword(s):  
Uric Acid ◽  
Renal Excretion ◽  
Proximal Tubules ◽  
Free Flow ◽  
Collecting Ducts ◽  
Order Of Magnitude ◽  
Plasma Urate ◽  
Distal Tubules

Free-flow micropuncture experiments were done in rats of three strains infused with small amounts of urate [plasma urate (P urate) = 95 +/- 8 muM]. Urate concentrations in tubular fluid were measured by an accurate chemical fluorometric ultramicromethod. In fluid from surface glomeruli, the glomerular fluid-to-plasma urate ratio [GF/P) urate] was 0.99 +/- 0.03 (n=11), i.e., lower than expected for total ultrafiltrability of plasma urate. Along proximal convolutions, net reabsorption of 55% of filtered urate was demonstrated. Small amounts of urate may have been reabsorbed between late proximal and early distal sites. Net transepithelial movements of urate did not occur in distal tubules or collecting ducts. In microperfusion experiments on proximal tubules, both a reabsorptive flow of urate (loss of perfused [2-14C]urate) and a secretory flow (entrance of cold urate into perfusate) of the same order of magnitude were demonstrated. Neither flow was influenced by simultaneous water movements. Microperfusion of Henle's loops indicated a significant but very small net reabsorption.

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