The role of TRPV1 receptor in the hypothalamus

2011 ◽  
Author(s):  
A. Zsombok ◽  
H. Gao ◽  
K. Myata ◽  
K D. Hebert ◽  
M. D. Bhaskaran ◽  
...  
Keyword(s):  
Trpv1 Receptor

Tu1426 Differences in the Control of Distension-Induced Secondary Peristalsis in Human Esophagus: the Role of 5-HT4 Receptor Versus TRPV1 Receptor

2015 ◽  
Vol 148 (4) ◽  
pp. S-887
Author(s):  
Chien-Lin Chen ◽  
Tso-Tsai Liu ◽  
Chih-Hsun Yi ◽  
Wei-Yi Lei ◽  
Jui-Sheng Hung
Keyword(s):  
Trpv1 Receptor ◽  
Human Esophagus ◽  
Secondary Peristalsis

Role of TRPV1 receptor in inflammation and impairment of esophageal mucosal integrity in a murine model of nonerosive reflux disease

2018 ◽  
Vol 30 (8) ◽  
pp. e13340 ◽  
Author(s):  
R. O. Silva ◽  
R. D. Bingana ◽  
T. M. A. L. Sales ◽  
R. L. R. Moreira ◽  
D. V. S. Costa ◽  
...  
Keyword(s):  
Murine Model ◽  
Reflux Disease ◽  
Trpv1 Receptor ◽  
Nonerosive Reflux Disease ◽  
Mucosal Integrity

Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model

2005 ◽  
Vol 169 (1-2) ◽  
pp. 86-96 ◽  
Author(s):  
Ágnes Bánvölgyi ◽  
László Pálinkás ◽  
Tímea Berki ◽  
Natalie Clark ◽  
Andrew D. Grant ◽  
...  
Keyword(s):  
Protective Role ◽  
Trpv1 Receptor ◽  
Allergic Dermatitis

Acid-induced modulation of airway basal tone and contractility: Role of acid-sensing ion channels (ASICs) and TRPV1 receptor

Life Sciences ◽  
2007 ◽  
Vol 81 (13) ◽  
pp. 1094-1102 ◽  
Author(s):  
Christophe Faisy ◽  
Benjamin Planquette ◽  
Emmanuel Naline ◽  
Paul-André Risse ◽  
Nelly Frossard ◽  
...  
Keyword(s):  
Ion Channels ◽  
Trpv1 Receptor ◽  
Acid Sensing Ion Channels ◽  
Basal Tone

scholarly journals TRPV1 Receptors Contribute to Paclitaxel-Induced c-Fos Expression in Spinal Cord Dorsal Horn Neurons

2017 ◽  
pp. 549-552 ◽  
Author(s):  
N. KALYNOVSKA ◽  
P. ADAMEK ◽  
J. PALECEK
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Transient Receptor Potential ◽  
Spinal Cord Dorsal Horn ◽  
Transient Receptor Potential Vanilloid ◽  
Receptor Antagonists ◽  
Trpv1 Receptor ◽  
Dorsal Horn Neurons ◽  
Trpv1 Receptors

Transient receptor potential vanilloid type 1 (TRPV1) receptors are important in the development of different pathological chronic pain states. Here we examined the role of spinal cord TRPV1 receptors in the mechanisms leading to activation of dorsal horn neurons after paclitaxel (PAC) treatment. PAC is a widely used chemotherapeutic drug that often leads to development of painful neuropathy. Immunohistochemical analysis of c-Fos protein expression in dorsal horn neurons was used as a marker of neuronal activation. Rat spinal cord slices were processed for in vitro incubation with PAC (100 nM) and TRPV1 receptor antagonists (SB366791 and AMG9810; 10 µM). PAC treatment induced significant upregulation of c-Fos nuclear expression in superficial dorsal horn neurons that was diminished by TRPV1 receptor antagonists pre-incubation. These results further substantiated the role of spinal TRPV1 receptors in the development of paclitaxel-induced neuropathic pain and contribute to better understanding of the pathological mechanisms involved.

scholarly journals Recovery of Capsaicinoids and Other Phytochemicals Involved With TRPV-1 Receptor to Re-valorize Chili Pepper Waste and Produce Nutraceuticals

2021 ◽  
Vol 4 ◽  
Author(s):  
Hector Emmanuel Cortés-Ferré ◽  
Daniel Guajardo-Flores ◽  
Gregorio Romero-De La Vega ◽  
Janet Alejandra Gutierrez-Uribe
Keyword(s):  
Industrial Process ◽  
Chili Pepper ◽  
Waste Materials ◽  
Viral Diseases ◽  
Asian Countries ◽  
Trpv1 Receptor ◽  
Immune System Diseases ◽  
New Methods ◽  
Staple Foods

The hot chili pepper industry represents one of the most important staple foods in Mexico and many Asian countries. Nowadays, large amounts of waste materials are produced from the pepper supply chain that could be used as a source to obtain nutraceuticals. Among the most common and important bioactive compounds contained in pepper residues are the capsaicinoids, which are the responsible of the pungency of the pepper. Capsaicinoids, mainly capsaicin, may ameliorate obesity, gastric disorder, diabetes, cardiovascular diseases, cancer, rhinitis, asthma, immune system diseases, and important viral diseases as the recent COVID-19. The aim of this review is to review the industrial process for the extraction of capsaicinoids ingredients from pepper residues and to examine the relation of the capsaicin and other chili pepper phytochemicals to prevent and treat chronic diseases explained through the key role of the TRPV1 receptor. The extraction and incorporation of these compounds into nutraceutical formulations depend mainly on the development of new methods to improve not only the yield of a particular compound but the validation of the bioactivity and phytochemical characterization.

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