Enzyme induction and cortisone protection in endotoxin-poisoned mice at 25 C compared with that at 5 C

1965 ◽  
Keyword(s):  
1993 ◽  
Vol 89 (1) ◽  
pp. 165-171 ◽  
Author(s):  
Douglas G. Muench ◽  
O. William Archibold ◽  
Allen G. Good

1963 ◽  
Vol 238 (5) ◽  
pp. PC1910-PC1912
Author(s):  
Henry C. Pitot ◽  
Carl Peraino
Keyword(s):  

2008 ◽  
Vol 74 (15) ◽  
pp. 4847-4852 ◽  
Author(s):  
Anastasia Matthies ◽  
Thomas Clavel ◽  
Michael Gütschow ◽  
Wolfram Engst ◽  
Dirk Haller ◽  
...  

ABSTRACT The metabolism of isoflavones by gut bacteria plays a key role in the availability and bioactivation of these compounds in the intestine. Daidzein and genistein are the most common dietary soy isoflavones. While daidzein conversion yielding equol has been known for some time, the corresponding formation of 5-hydroxy-equol from genistein has not been reported previously. We isolated a strictly anaerobic bacterium (Mt1B8) from the mouse intestine which converted daidzein via dihydrodaidzein to equol as well as genistein via dihydrogenistein to 5-hydroxy-equol. Strain Mt1B8 was a gram-positive, rod-shaped bacterium identified as a member of the Coriobacteriaceae. Strain Mt1B8 also transformed dihydrodaidzein and dihydrogenistein to equol and 5-hydroxy-equol, respectively. The conversion of daidzein, genistein, dihydrodaidzein, and dihydrogenistein in the stationary growth phase depended on preincubation with the corresponding isoflavonoid, indicating enzyme induction. Moreover, dihydrogenistein was transformed even more rapidly in the stationary phase when strain Mt1B8 was grown on either genistein or daidzein. Growing the cells on daidzein also enabled conversion of genistein. This suggests that the same enzymes are involved in the conversion of the two isoflavones.


2013 ◽  
Vol 15 (1) ◽  
pp. 58-74 ◽  
Author(s):  
Masakazu Kakuni ◽  
Chihiro Yamasaki ◽  
Asato Tachibana ◽  
Yasumi Yoshizane ◽  
Yuji Ishida ◽  
...  

The Lancet ◽  
1976 ◽  
Vol 307 (7969) ◽  
pp. 1107-1108 ◽  
Author(s):  
J.V. Martin ◽  
P.J. Martin ◽  
D.M. Goldberg

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