Risks and benefits of hormone replacement therapy are not the only factors that women consider

1999 ◽  
2021 ◽  
Vol 81 (05) ◽  
pp. 549-554
Author(s):  
Marina Sourouni ◽  
Ludwig Kiesel

AbstractRapid advances in oncology have led to an increased survival rate in cancer patients, who live long enough to reach the natural age of menopause or experience the end of gonadal function as a side effect of oncological treatment. Survivors after gynaecological malignancies are a major challenge as these diseases are hormone-dependent and hormone replacement therapy (HRT) possibly increases the risk of recurrence. This article is based on a selective literature search for relevant studies and guidelines regarding HRT after gynaecological malignancies and provides a broad overview of current research. The data for assessing the oncological safety of HRT after gynaecological malignancy are insufficient overall. According to current knowledge, HRT is fundamentally contraindicated after breast and endometrial cancer. After ovarian cancer, HRT can be used after assessment of the risks and benefits, while there is usually no contraindication to HRT after vulvar, vaginal or cervical cancer.


1991 ◽  
Vol 16 (4) ◽  
pp. 231-245 ◽  
Author(s):  
T. C. Hillard ◽  
S. Whitcroft ◽  
M. C. Ellerington ◽  
M. I. Whitehead

2020 ◽  
Vol 7 ◽  
Author(s):  
Eriston Vieira Gomes

The climacteric is a physiological period of the female reproductive cycle characterized by a decrease in the levels of sex hormones, mainly estrogen. It consists of several phases, with amenorrhea as the initial clinical manifestation followed by long-term changes, such as vaginal atrophy. In this context, hormone replacement therapy (HRT) aims to improve the symptoms of female reproductive senescence, seeking to provide a comfortable physical and psychological condition during this period. However, as with any drug treatment, HRT has its risks and benefits, and it is up to the medical practitioner, in agreement with the patient, looking for the best therapeutic option, minimizing the risks and consequences resulting from this clinical approach.


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