scholarly journals Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive–compulsive disorder.

2020 ◽  
Author(s):  
Safoora Naaz ◽  
Srinivas Balachander ◽  
Nithyananda Srinivasa Murthy ◽  
Bhagyalakshmi MS ◽  
Reeteka Sud ◽  
...  
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Pharmacological Treatment ◽  
Obsessive Compulsive ◽  
Allelic Variants ◽  
Symptom Dimensions ◽  
Compulsive Disorder

scholarly journals Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder

2020 ◽  
Author(s):  
Safoora Naaz ◽  
Srinivas Balachander ◽  
Nithyananda Srinivasa Murthy ◽  
MS Bhagyalakshmi ◽  
Reeteka Sud ◽  
...  
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Pharmacological Treatment ◽  
Serotonin Reuptake ◽  
Factor Score ◽  
Contamination Factor ◽  
Obsessive Compulsive ◽  
Allelic Variants ◽  
Compulsive Disorder

AbstractBackgroundThough several SAPAP3 gene knockout studies in mice have implicated its role in compulsivity, human studies have failed to demonstrate its association with obsessive-compulsive disorder (OCD). We examined the association between allelic variants of a single nucleotide polymorphism in the SAPAP3 gene (rs6662980) with specific aspects of the OCD phenotype.MethodsA total of 200 subjects with OCD were genotyped using the TaqMan assay. All subjects were assessed using Mini International Neuropsychiatric Interview, the Yale-Brown Obsessive-Compulsive Scale, and their treatment response was evaluated over naturalistic treatment and follow-up.ResultsAfter correcting for multiple comparisons, G-allele at rs6662980 was found to be associated with contamination/washing symptoms (p=0.003). Logistic regression analysis also showed that presence of G allele predicted poor response to serotonin reuptake inhibitors [odds ratio = 2.473 (95% CI = 1.157 - 5.407), p=0.021]. Interaction between presence of G-allele and contamination factor score predicted SRI resistance (B= 1.197, p = 0.006).LimitationsWe did not use a dimensional measure for assessing OCD symptoms. Treatment response was assessed over naturalistic follow-up.ConclusionSpecific phenotypic manifestations of OCD, which include contamination and washing-related symptoms along with resistance to serotonin reuptake inhibitors, may be related to alterations in the SAPAP3 gene.Public Significance Statement“This study finds that a specific polymorphism in the SAPAP3 gene, was found to be associated with the contamination/washing symptoms of OCD and was also found to predict resistance to pharmacological treatment”HighlightsSAPAP3 gene is implicated in OCDAssociation of SAPAP3 gene (rs6662980) with OCD phenotypes was examinedPresence of the minor (G) allele predicted contamination & washing symptomsSAPAP3 polymorphism had a significant association with treatment responseInteraction between presence of G-allele and contamination factor score predicted treatment resistance

Does GRIN2B gene influence obsessive-compulsive disorder risk, symptom dimensions and treatment response?

2018 ◽  
Vol 31 ◽  
pp. 150-151 ◽  
Author(s):  
Biju Viswanath ◽  
Reshma Jabeen Taj MJ ◽  
Ravi Kumar Nadella ◽  
Tulika Shukla ◽  
Madhuri H. Nanjundaswamy ◽  
...  
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Symptom Dimensions ◽  
Compulsive Disorder ◽  
Risk Symptom ◽  
Disorder Risk

Patterns of Neural Response to Emotive Stimuli Distinguish the Different Symptom Dimensions of Obsessive-Compulsive Disorder

CNS Spectrums ◽  
2004 ◽  
Vol 9 (4) ◽  
pp. 275-283 ◽  
Author(s):  
Mary L. Phillips ◽  
David Mataix-Cols
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Emotion Perception ◽  
Anterior Cingulate ◽  
Neural Systems ◽  
Obsessive Compulsive ◽  
Specific Symptom ◽  
Symptom Dimensions ◽  
Related Material ◽  
Compulsive Disorder

ABSTRACTDespite its heterogeneous symptomatology, obsessive-compulsive disorder (OCD) is currently conceptualized as a unitary diagnostic entity. Recent factor-analytic studies have identified several OCD symptom dimensions that are associated with different demographic variables, comorbidity, patterns of genetic transmission, and treatment response. Functional abnormalities in neural systems important for emotion perception, including the orbitofrontal cortex, lateral prefrontal cortex, anterior cingulate gyrus, and limbic regions, have been reported in OCD. In this review, we discuss the extent to which neurobiological markers may distinguish these different symptom dimensions and whether specific symptom dimensions, such as contamination/washing, are associated with abnormalities in emotion and, in particular, disgust, perception in OCD. Also discussed are findings that indicate that anxiety can be induced in healthy volunteers in response to OCD symptom-related material, and that associated increases in activity within neural systems important for emotion perception occur to washing- and hoarding-related material in particular in these subjects. Further examination of neural responses during provocation of different symptom dimensions in OCD patients will help determine the extent to which specific abnormalities in neural systems underlying emotion perception are associated with different symptom dimensions and predict treatment response in OCD.

Escitalopram in Obsessive-Compulsive Disorder: Response of Symptom Dimensions to Pharmacotherapy

CNS Spectrums ◽  
2008 ◽  
Vol 13 (6) ◽  
pp. 492-498 ◽  
Author(s):  
Dan J. Stein ◽  
Paul D. Carey ◽  
Christine Lochner ◽  
Soraya Seedat ◽  
Naomi Fineberg ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Exploratory Factor Analysis ◽  
Subscale Score ◽  
Controlled Study ◽  
Obsessive Compulsive ◽  
Double Blind ◽  
Symptom Dimensions ◽  
Compulsive Disorder

ABSTRACTIntroduction:There is a substantial body of evidence that obsessive-compulsive disorder (OCD) symptoms can be grouped into a series of discrete dimensions, and some evidence that not all OCD symptom dimensions respond equally well to pharmacologic or psychotherapeutic intervention. The response of OCD symptom dimensions to 12 weeks of treatment with escitalopram or placebo was investigated.Methods:Data from a randomized, double-blind, placebo-controlled study of escitalopram in 466 adults with OCD were analyzed. Exploratory factor analysis of individual items of the Yale-Brown Obsessive-Compulsive Scale checklist was performed and subscale scores based on the extracted factors were determined. Analyses of covariance were undertaken to determine whether inclusion of each subscale score in these models impacted on the efficacy of escitalopram versus placebo.Results:Exploratory factor analysis of individual Yale-Brown Obsessive-Compulsive Scale items yielded 5 factors (contamination/cleaning, harm/checking, hoarding/symmetry, religious/sexual, and somatic/hypochondriacal). Analyses of covariance including all the subscales demonstrated that escitalopram was more effective than placebo. There was a significant interaction for the hoarding/symmetry factor, which was associated with a poor treatment response.Conclusion:Escitalopram shows good efficacy across the range of OCD symptom dimensions. Nevertheless, hoarding/symmetry was associated with a poorer treatment response. Hoarding/symmetry may be particularly characteristic of an early-onset group of OCD patients, with the involvement of neurotransmitters other than serotonin. Further work is needed to delineate fully the subtypes of OCD, and their correlates with underlying psychobiology and treatment responsivity.

BDNF gene and obsessive compulsive disorder risk, symptom dimensions and treatment response

2018 ◽  
Vol 38 ◽  
pp. 65-69 ◽  
Author(s):  
Reshma Jabeen Taj M J ◽  
Suhas Ganesh ◽  
Tulika Shukla ◽  
Sayali Deolankar ◽  
Ravi K. Nadella ◽  
...  
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Bdnf Gene ◽  
Obsessive Compulsive ◽  
Symptom Dimensions ◽  
Compulsive Disorder ◽  
Risk Symptom ◽  
Disorder Risk
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