The impact of obsessive beliefs on pharmacological treatment response in patients with obsessive-compulsive disorder

2011 ◽  
Vol 15 (3) ◽  
pp. 209-213 ◽  
Author(s):  
Yavuz Selvi ◽  
Abdullah Atli ◽  
Lutfullah Besiroglu ◽  
Adem Aydin ◽  
Mustafa Gulec
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Pharmacological Treatment ◽  
Obsessive Beliefs ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Impact

Epidemiology of Obsessive-Compulsive Disorder: Cross Culture and Economy

CNS Spectrums ◽  
1999 ◽  
Vol 4 (S3) ◽  
pp. 6-12
Author(s):  
Donald W. Black
Keyword(s):  
Quality Of Life ◽  
South Africa ◽  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
The United States ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Impact

AbstractThis manuscript summarizes the presentations of an international panel of experts, representing France, Hungary, India, South Africa, and the United States, on obsessive-compulsive disorder (OCD). OCD is culturally universal but probably heterogeneous. New data presented concern a follow-up study from a joint Yale-Brown clinical project; a prevalence study in Hungary; a molecular genetics study from South Africa; a comorbidity study from India; a clinical study from Paris comparing OCD with subclinical OCD; a discussion of compulsive buying as a cross-cultural phenomenon; and survey results showing the impact of OCD on quality of life and economic variables. A roundtable discussion led to a consensus that researchers must continue to: (1) investigate the prevalence of OCD in non Western samples and in less developed countries; (2) collect clinical data on OCD in child and adolescent samples, as well as in off-spring of adults with OCD; (3) refine the concept of age of onset; (4) study the impact of OCD on quality of life and the economy; (5) investigate the validity of the obsessive-compulsive spectrum in epidemiologic and clinical samples and develop appropriate instruments for its assessment; (6) study personality disorder and how it affects treatment response, and examine its prevalence in epidemiologic samples; (7) explore the concept of OCD heterogeneity, which may reflect differing etiologies but may also suggest differential treatment strategies; (8) conduct follow-up studies, particularly now that effective treatments may alter course of illness; and, finally, (9) investigate treatment response and whether certain subtypes demand unique approaches.

scholarly journals Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder

2020 ◽  
Author(s):  
Safoora Naaz ◽  
Srinivas Balachander ◽  
Nithyananda Srinivasa Murthy ◽  
MS Bhagyalakshmi ◽  
Reeteka Sud ◽  
...  
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Pharmacological Treatment ◽  
Serotonin Reuptake ◽  
Factor Score ◽  
Contamination Factor ◽  
Obsessive Compulsive ◽  
Allelic Variants ◽  
Compulsive Disorder

AbstractBackgroundThough several SAPAP3 gene knockout studies in mice have implicated its role in compulsivity, human studies have failed to demonstrate its association with obsessive-compulsive disorder (OCD). We examined the association between allelic variants of a single nucleotide polymorphism in the SAPAP3 gene (rs6662980) with specific aspects of the OCD phenotype.MethodsA total of 200 subjects with OCD were genotyped using the TaqMan assay. All subjects were assessed using Mini International Neuropsychiatric Interview, the Yale-Brown Obsessive-Compulsive Scale, and their treatment response was evaluated over naturalistic treatment and follow-up.ResultsAfter correcting for multiple comparisons, G-allele at rs6662980 was found to be associated with contamination/washing symptoms (p=0.003). Logistic regression analysis also showed that presence of G allele predicted poor response to serotonin reuptake inhibitors [odds ratio = 2.473 (95% CI = 1.157 - 5.407), p=0.021]. Interaction between presence of G-allele and contamination factor score predicted SRI resistance (B= 1.197, p = 0.006).LimitationsWe did not use a dimensional measure for assessing OCD symptoms. Treatment response was assessed over naturalistic follow-up.ConclusionSpecific phenotypic manifestations of OCD, which include contamination and washing-related symptoms along with resistance to serotonin reuptake inhibitors, may be related to alterations in the SAPAP3 gene.Public Significance Statement“This study finds that a specific polymorphism in the SAPAP3 gene, was found to be associated with the contamination/washing symptoms of OCD and was also found to predict resistance to pharmacological treatment”HighlightsSAPAP3 gene is implicated in OCDAssociation of SAPAP3 gene (rs6662980) with OCD phenotypes was examinedPresence of the minor (G) allele predicted contamination & washing symptomsSAPAP3 polymorphism had a significant association with treatment responseInteraction between presence of G-allele and contamination factor score predicted treatment resistance

Influence of pharmacological treatment on obsessive beliefs in the patients with obsessive compulsive disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 979-979
Author(s):  
Y. Selvi ◽  
L. Besiroglu ◽  
A. Aydin ◽  
A. Atli ◽  
M. Gulec
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Rating Scale ◽  
Negative Mood ◽  
Dysfunctional Beliefs ◽  
Obsessive Beliefs ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Mean ◽  
And Control

IntroductionCognitive models hypothesize that certain dysfunctional beliefs leading to misinterpretation of the significance of intrusions are important in the etiology and maintenance of obsessive-compulsive disorder (OCD). There is no consensus about which characteristics of OCD patients more likely to be associated with better treatment response.ObjectivesWe aimed to investigate whether obsessive beliefs change over time in the OCD patients receiving Serotonin Reuptake Inhibitors. We also investigated the effect of change in obsessive beliefs on psychopharmacological treatment response.MethodsA sample of 75 patients with OCD were interviewed the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and Hamilton Depression Rating Scale (HDRS). To measure dysfunctional beliefs, they were administered the Obsessive Beliefs Questionnaire-44 (OBQ-44) which contains three subscales; threat overestimation and responsibility, importance and control of intrusive thoughts, and perfectionism and need for certainty.ResultsThe seventy-six percent (n=57) patients completed the treatment period and they were reassessed after 12 weeks with the Y-BOCS, HDRS and OBQ-44. The mean change scores of responders for OBQ-44 Responsibility/Threat Estimation and OBQ-44 Perfectionism/Certainty were not significantly differing from those of non-responders. The mean change in responders for OBQ-44 Importance/Control of Thoughts and HDRS were significantly higher than non responders.ConclusionsOur results suggest that treatment response to pharmacotherapy in OCD is negatively associated with the obsessive beliefs about perfectionism and certainty. The alleviation of negative mood by SRIs may not allow the sufferer disengages from dysfunctional appraisals.

Reducing the Social Stigma Associated with Obsessive Compulsive Disorder: A Controlled Trial of an Intervention Program in a Turkish Community Sample

2020 ◽  
Vol 20 (2) ◽  
pp. 101-120
Author(s):  
Ayça Aktaç Gürbüz ◽  
Orçun YORULMAZ ◽  
Gülşah DURNA
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Intervention Program ◽  
Controlled Trial ◽  
Community Sample ◽  
Case Vignette ◽  
Control Group ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Significant Difference ◽  
The Impact

Scientific research into the reduction of stigmatization, particularly related to specific problems such as Obsessive-Compulsive Disorder (OCD), is scarce. In the present study, we examine the impact of a video-based antistigma intervention program for OCD in a pretest-posttest control group research. After being randomly assigned to either an intervention (n= 101) or control group (n= 96), the participants reported their attitudes on a hypothetical case vignette before and after OCD vs. Multiple Sclerosis (MS) videos, and again six months later as a follow up assessment. The mixed design analyses for the group comparisons indicated that although there was no significant difference in the measures of the control group, the participants watching the anti-stigma OCD video, in which the focus was psychoeducation and interaction strategies, reported significantly lower scores on social distances and negative beliefs for the case vignettes they read, and this difference was maintained six months later. Then, the present results indicate the effectiveness of our anti-stigma intervention program for OCD. Interventions to reduce stigmatization can also be viewed as effective tools for changing the attitudes of people toward OCD, although further research and applications are needed related to specific disorders if a longlasting impact is to be achieved.

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