Temperament and character inventory: Predictor of pharmacological treatment response in obsessive compulsive disorder?

2001 ◽  
Vol 11 ◽  
pp. S304
Author(s):  
N.H. Tenney ◽  
G. Glas ◽  
H.G.M. Van Megen ◽  
H.G.M. Westenberg
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Pharmacological Treatment ◽  
Temperament And Character Inventory ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Character Inventory

Severity of Obsessive-Compulsive Symptoms is Related to Self-Directedness Character Trait in Obsessive-Compulsive Disorder

CNS Spectrums ◽  
2004 ◽  
Vol 9 (8) ◽  
pp. 607-612 ◽  
Author(s):  
Carlos Cruz-Fuentes ◽  
Claudia Blas ◽  
Laura Gonzalez ◽  
Beatriz Camarena ◽  
Humberto Nicolini
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Rating Scales ◽  
Character Trait ◽  
Depression And Anxiety ◽  
Temperament And Character Inventory ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Behavioral Features ◽  
Character Inventory

ABSTRACT:Objective:The present study examined the psychobiological Temperament and Character model of personality on obsessive-compulsive disorder (OCD) patients, as well as the relation of temperament and/or character dimensions on the severity of obsessive-compubive symptoms.Methods:Fifty-four subjects diagnosed with OCD, were assessed with the Temperament and Character Inventory, the Yale-Brown Obsessive-Compulsive scale and the Hamilton Rating Scales for depression and anxiety.Results:Compared with controls, OCD subjects displayed increased harm avoidance and lower self-directedness and cooperativeness. Low self-directedness and high Hamilton depression scores were associated with increased severity of obsessive-compulsive symptoms.Conclusions:The Temperament and Character profile of OCD patients characterized in the present stud personality model and can be linked to some of their behavioral features. Furthermore, our data provides support of the influence that some personality traits may have on the severity of OCD symptoms.

Dissociation is Related to Self-directedness and Self-transcedence Character Traits in Obsessive-compulsive Disorder

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M. Raszka ◽  
J. Prako ◽  
J. Kopřivová
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Harm Avoidance ◽  
Personality Factors ◽  
Regression Analyses ◽  
Temperament And Character Inventory ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Dissociative Experiences ◽  
Character Inventory ◽  
Neuropsychiatric Conditions

Introduction:The purpose of this study was to investigate the temperament and character patterns in patients with obsessive-compulsive disorder (OCD) and to determine whether any presupposed relationship between harm avoidance, self-directedness, self-transcedence scores and dissociation in patients with OCD is present.Methods:The study sample comprised of 43 patients with OCD (26 females) and 44 healthy controls (29 females). All subjects were assessed with the Temperament and Character Inventory (TCI), Beck Depression Inventory-II (BDI-II), and Beck Anxiety Inventory (BAI). Dissociation was quantified by the Dissociative Experiences Scale (DES). Obsessive-compulsive symptoms in OCD group were assessed with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Correlation, unpaired t-test with Bonferroni correction for seven comparisons, and multiple linear regression analyses were performed.Results:OCD patients had significantly higher scores of harm avoidance and self-directedness compared with healthy comparison subjects. Dissociative experiences were more frequent in OCD patients comparing with controls. DES scores had negative correlation with self-directedness and positively correlated with self-transcedence scores, as well as with BDI-II and BAI scores in OCD group. Multiple regression analyses revealed that the severity of depressive symptoms, self-directedness and self-transcedence scores predicted the DES score. There was no significant correlation between severity of OCD symptoms and patterns of temperament and character.Conclusion:Dissociation is associated with self-directedness and self-transcedence dimensions of the Temperament and Character Inventory in OCD subjects. It emphasize the importance of considering the influence of dissociation in further studies of personality factors in neuropsychiatric conditions.This research was supported by grant MZ ČR IGA 9323-3/2007.

scholarly journals Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder

2020 ◽  
Author(s):  
Safoora Naaz ◽  
Srinivas Balachander ◽  
Nithyananda Srinivasa Murthy ◽  
MS Bhagyalakshmi ◽  
Reeteka Sud ◽  
...  
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Pharmacological Treatment ◽  
Serotonin Reuptake ◽  
Factor Score ◽  
Contamination Factor ◽  
Obsessive Compulsive ◽  
Allelic Variants ◽  
Compulsive Disorder

AbstractBackgroundThough several SAPAP3 gene knockout studies in mice have implicated its role in compulsivity, human studies have failed to demonstrate its association with obsessive-compulsive disorder (OCD). We examined the association between allelic variants of a single nucleotide polymorphism in the SAPAP3 gene (rs6662980) with specific aspects of the OCD phenotype.MethodsA total of 200 subjects with OCD were genotyped using the TaqMan assay. All subjects were assessed using Mini International Neuropsychiatric Interview, the Yale-Brown Obsessive-Compulsive Scale, and their treatment response was evaluated over naturalistic treatment and follow-up.ResultsAfter correcting for multiple comparisons, G-allele at rs6662980 was found to be associated with contamination/washing symptoms (p=0.003). Logistic regression analysis also showed that presence of G allele predicted poor response to serotonin reuptake inhibitors [odds ratio = 2.473 (95% CI = 1.157 - 5.407), p=0.021]. Interaction between presence of G-allele and contamination factor score predicted SRI resistance (B= 1.197, p = 0.006).LimitationsWe did not use a dimensional measure for assessing OCD symptoms. Treatment response was assessed over naturalistic follow-up.ConclusionSpecific phenotypic manifestations of OCD, which include contamination and washing-related symptoms along with resistance to serotonin reuptake inhibitors, may be related to alterations in the SAPAP3 gene.Public Significance Statement“This study finds that a specific polymorphism in the SAPAP3 gene, was found to be associated with the contamination/washing symptoms of OCD and was also found to predict resistance to pharmacological treatment”HighlightsSAPAP3 gene is implicated in OCDAssociation of SAPAP3 gene (rs6662980) with OCD phenotypes was examinedPresence of the minor (G) allele predicted contamination & washing symptomsSAPAP3 polymorphism had a significant association with treatment responseInteraction between presence of G-allele and contamination factor score predicted treatment resistance

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