Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion

Nature ◽  
1981 ◽  
Vol 291 (5810) ◽  
pp. 76-77 ◽  
Author(s):  
Lawrence Mandarino ◽  
Debra Stenner ◽  
Wayne Blanchard ◽  
Steven Nissen ◽  
John Gerich ◽  
...  
Keyword(s):  
Glucagon Secretion ◽  
Insulin And Glucagon Secretion ◽  
Selective Effects ◽  
Somatostatin 14

Adaptive changes in insulin and glucagon secretion during cold acclimation in the rat

1986 ◽  
Vol 250 (6) ◽  
pp. E669-E676 ◽  
Author(s):  
C. I. Edwards ◽  
R. J. Howland
Keyword(s):  
Cold Acclimation ◽  
Cold Exposure ◽  
Hormone Secretion ◽  
Glucagon Secretion ◽  
Molar Ratio ◽  
Adaptive Process ◽  
Insulin And Glucagon Secretion ◽  
Pancreatic Hormone

Arginine-stimulated insulin and glucagon outputs from isolated perfused pancreata of warm-acclimated and 2-, 4-, and 6-wk cold-acclimated rats (4 degrees C) were determined to assess whether observed changes in these parameters were a result of cold exposure per se or a part of the adaptive process of cold acclimation. Progressive and sequential changes were seen in both insulin and glucagon outputs. At 2 wk cold acclimation, glucagon rose and insulin output tended to fall, at 4 wk, glucagon output remained elevated and insulin output was further reduced, and at 6 wk, glucagon output had returned to control levels, whereas insulin output was substantially further reduced. These changes resulted in reduction of the insulin-to-glucagon molar ratio of the total arginine-induced output from 7.27 +/- 1.76 (SE) in the warm acclimate to 2.31 +/- 0.79 (SE) at 2 wk, 1.42 +/- 0.29 (SE) at 4 wk, and 1.26 +/- 0.21 (SE) at 6 wk cold acclimation. The data do not provide in vitro support for the hypothesis that changes in pancreatic hormone secretion in vivo are a consequence of cold exposure and not cold acclimation.

Regulation of insulin and glucagon secretion from rat pancreatic islets in vitro by somatostatin analogues

2007 ◽  
Vol 138 (1) ◽  
pp. 1-9 ◽  
Author(s):  
E. Ludvigsen ◽  
M. Stridsberg ◽  
J.E. Taylor ◽  
M.D. Culler ◽  
K. Öberg ◽  
...  
Keyword(s):  
Pancreatic Islets ◽  
Glucagon Secretion ◽  
Somatostatin Analogues ◽  
Rat Pancreatic Islets ◽  
Insulin And Glucagon Secretion

Effects of porcine diazepam-binding inhibitor on insulin and glucagon secretion in vitro from the rat endocrine pancreas

1990 ◽  
Vol 29 (2-3) ◽  
pp. 143-151 ◽  
Author(s):  
Claes-Göran Östenson ◽  
Bo Ahrén ◽  
Sven Karlsson ◽  
Elvi Sandberg ◽  
Suad Efendic
Keyword(s):  
Endocrine Pancreas ◽  
Glucagon Secretion ◽  
Insulin And Glucagon Secretion

M&B 39890A, a novel sulphonamido-benzamide compound, inhibits insulin and glucagon secretion in vitro

1989 ◽  
Vol 38 (15) ◽  
pp. 2565-2568 ◽  
Author(s):  
Ramona A. Silvestre ◽  
Elena Peiró ◽  
Paloma Miralles ◽  
José Marco
Keyword(s):  
Glucagon Secretion ◽  
Insulin And Glucagon Secretion

[Ala6]gastrin-releasing peptide-10: an analogue with dissociated biological activities

1989 ◽  
Vol 257 (2) ◽  
pp. E235-E240
Author(s):  
H. Mukai ◽  
K. Kawai ◽  
S. Suzuki ◽  
H. Ohmori ◽  
K. Yamashita ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Biological Activities ◽  
Glucagon Secretion ◽  
Gastrin Releasing Peptide ◽  
Gastrin Secretion ◽  
Insulin And Glucagon Secretion ◽  
Mammalian Tissues ◽  
Stimulation Of

COOH-terminal decapeptide of gastrin-releasing peptide (GRP-10) is a bombesin-like peptide, which has bioactivities to stimulate gastrin, insulin, and glucagon secretion. We have synthesized an analogue of GRP-10 that inhibits GRP-10's stimulation of insulin secretion both in vivo and in vitro and glucagon secretion in vivo, while potentiating the stimulation of gastrin secretion. The amino acid sequence of this peptide is H-Gly-Asn-Trp-Ala-Ala-Gly-His-Leu-Met-NH2 ([Ala6]GRP-10). Because the stimulation of insulin and gastrin secretion by GRP-10 has been ascribed to a direct effect on B- and G-cells, these findings suggest that there are two subtypes of receptors for bombesin-like peptides in mammalian tissues.

ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue

2002 ◽  
Vol 283 (6) ◽  
pp. E1178-E1184 ◽  
Author(s):  
Takashi Miki ◽  
Kohtaro Minami ◽  
Li Zhang ◽  
Mizuo Morita ◽  
Tohru Gonoi ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Uptake ◽  
Skeletal Muscles ◽  
Glucagon Secretion ◽  
Channel Activity ◽  
Wild Type ◽  
Insulin And Glucagon Secretion ◽  
Uptake Experiment

ATP-sensitive potassium (KATP) channels are known to be critical in the control of both insulin and glucagon secretion, the major hormones in the maintenance of glucose homeostasis. The involvement of KATPchannels in glucose uptake in the target tissues of insulin, however, is not known. We show here that Kir6.2(−/−) mice lacking Kir6.2, the pore-forming subunit of these channels, have no KATPchannel activity in their skeletal muscles. A 2-deoxy-[3H]glucose uptake experiment in vivo showed that the basal and insulin-stimulated glucose uptake in skeletal muscles and adipose tissues of Kir6.2(−/−) mice is enhanced compared with that in wild-type (WT) mice. In addition, in vitro measurement of glucose uptake indicates that disruption of the channel increases the basal glucose uptake in Kir6.2(−/−) extensor digitorum longus and the insulin-stimulated glucose uptake in Kir6.2(−/−) soleus muscle. In contrast, glucose uptake in adipose tissue, measured in vitro, was similar in Kir6.2(−/−) and WT mice, suggesting that the increase in glucose uptake in Kir6.2(−/−) adipocytes is mediated by altered extracellular hormonal or neuronal signals altered by disruption of the KATP channels.

Sign in / Sign up

Export Citation Format

Share Document