Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input

Nature ◽  
1987 ◽  
Vol 325 (6100) ◽  
pp. 151-153 ◽  
Author(s):  
Alison J. Cook ◽  
Clifford J. Woolf ◽  
Patrick D. Wall ◽  
Stephen B. McMahon
Keyword(s):  
Spinal Cord ◽  
Receptive Field ◽  
Dorsal Horn ◽  
Afferent Input ◽  
Spinal Cord Dorsal Horn ◽  
Rat Spinal Cord ◽  
Primary Afferent ◽  
Spinal Cord Dorsal

Microglial refinement of spinal cord sensory circuitry regulates normal maturation of dynamic touch.

2021 ◽  
Author(s):  
Yajing Xu ◽  
Stephanie Koch ◽  
Alexander Chamessian ◽  
Qianru He ◽  
Mayya Sundukova ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Normal Development ◽  
Physiological Role ◽  
Spinal Cord Dorsal Horn ◽  
Dynamic Touch ◽  
Tactile Sensitivity ◽  
Primary Afferent ◽  
Spinal Cord Dorsal

In the spinal cord dorsal horn, sensory circuits undergo remarkable postnatal reorganisation, including refinement of primary afferent A-fibres in the superficial layers, accompanied by decreased cutaneous sensitivity. Here we show a physiological role of microglia necessary for normal development of dorsal horn sensory circuits and tactile sensitivity. In the absence of microglial engulfment, superfluous A-fibre projections persist, leading to lifelong hypersensitivity to dynamic touch.

scholarly journals Xenon Inhibits Excitatory but Not Inhibitory Transmission in Rat Spinal Cord Dorsal Horn Neurons

2010 ◽  
Vol 6 ◽  
pp. 1744-8069-6-25 ◽  
Author(s):  
Stefan K Georgiev ◽  
Hidemasa Furue ◽  
Hiroshi Baba ◽  
Tatsuro Kohno
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Spinal Cord Dorsal Horn ◽  
Rat Spinal Cord ◽  
Inhibitory Transmission ◽  
Dorsal Horn Neurons ◽  
Spinal Cord Dorsal

Intradermal injection of capsaicin induces acute substance P release from rat spinal cord dorsal horn

2006 ◽  
Vol 410 (3) ◽  
pp. 183-186 ◽  
Author(s):  
Jing-Yin Yan ◽  
Rui-Qing Sun ◽  
Michael G. Hughes ◽  
David J. McAdoo ◽  
William D. Willis
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Dorsal Horn ◽  
Intradermal Injection ◽  
Spinal Cord Dorsal Horn ◽  
Rat Spinal Cord ◽  
P Release ◽  
Spinal Cord Dorsal ◽  
Substance P Release
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