Microglial refinement of spinal cord sensory circuitry regulates normal maturation of dynamic touch.

2021 ◽  
Author(s):  
Yajing Xu ◽  
Stephanie Koch ◽  
Alexander Chamessian ◽  
Qianru He ◽  
Mayya Sundukova ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Normal Development ◽  
Physiological Role ◽  
Spinal Cord Dorsal Horn ◽  
Dynamic Touch ◽  
Tactile Sensitivity ◽  
Primary Afferent ◽  
Spinal Cord Dorsal

In the spinal cord dorsal horn, sensory circuits undergo remarkable postnatal reorganisation, including refinement of primary afferent A-fibres in the superficial layers, accompanied by decreased cutaneous sensitivity. Here we show a physiological role of microglia necessary for normal development of dorsal horn sensory circuits and tactile sensitivity. In the absence of microglial engulfment, superfluous A-fibre projections persist, leading to lifelong hypersensitivity to dynamic touch.

scholarly journals Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to Circuits

2021 ◽  
Vol 22 (1) ◽  
pp. 414
Author(s):  
Antonella Comitato ◽  
Rita Bardoni
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Sensory Information ◽  
Spinal Cord Dorsal Horn ◽  
Primary Afferent ◽  
Dorsal Horn Neurons ◽  
Afferent Fibers ◽  
Peptide Release ◽  
Spinal Cord Dorsal ◽  
Primary Afferent Fibers

Sensory primary afferent fibers, conveying touch, pain, itch, and proprioception, synapse onto spinal cord dorsal horn neurons. Primary afferent central terminals express a wide variety of receptors that modulate glutamate and peptide release. Regulation of the amount and timing of neurotransmitter release critically affects the integration of postsynaptic responses and the coding of sensory information. The role of GABA (γ-aminobutyric acid) receptors expressed on afferent central terminals is particularly important in sensory processing, both in physiological conditions and in sensitized states induced by chronic pain. During the last decade, techniques of opto- and chemogenetic stimulation and neuronal selective labeling have provided interesting insights on this topic. This review focused on the recent advances about the modulatory effects of presynaptic GABAergic receptors in spinal cord dorsal horn and the neural circuits involved in these mechanisms.

scholarly journals Somatotopic organization of single primary afferent axon projections to cat spinal cord dorsal horn

1991 ◽  
Vol 11 (1) ◽  
pp. 298-309 ◽  
Author(s):  
PB Brown ◽  
WE Gladfelter ◽  
JC Culberson ◽  
D Covalt-Dunning ◽  
RV Sonty ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Spinal Cord Dorsal Horn ◽  
Primary Afferent ◽  
Somatotopic Organization ◽  
Spinal Cord Dorsal

Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input

Nature ◽  
1987 ◽  
Vol 325 (6100) ◽  
pp. 151-153 ◽  
Author(s):  
Alison J. Cook ◽  
Clifford J. Woolf ◽  
Patrick D. Wall ◽  
Stephen B. McMahon
Keyword(s):  
Spinal Cord ◽  
Receptive Field ◽  
Dorsal Horn ◽  
Afferent Input ◽  
Spinal Cord Dorsal Horn ◽  
Rat Spinal Cord ◽  
Primary Afferent ◽  
Spinal Cord Dorsal

scholarly journals Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

Neuron ◽  
2014 ◽  
Vol 81 (6) ◽  
pp. 1443 ◽  
Author(s):  
Rita Bardoni ◽  
Vivianne L. Tawfik ◽  
Dong Wang ◽  
Amaury François ◽  
Carlos Solorzano ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Opioid Receptors ◽  
Spinal Cord Dorsal Horn ◽  
Mechanosensory Neuron ◽  
Delta Opioid Receptors ◽  
Spinal Cord Dorsal
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