Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death

Nature ◽  
1992 ◽  
Vol 360 (6406) ◽  
pp. 753-755 ◽  
Author(s):  
Qiao Yan ◽  
Jeffrey Elliott ◽  
William D. Snider
Keyword(s):  
Cell Death ◽  
Motor Neurons ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Spinal Motor Neurons ◽  
Spinal Motor

scholarly journals Hepatocyte Growth Factor/Scatter Factor Is an Axonal Chemoattractant and a Neurotrophic Factor for Spinal Motor Neurons

Neuron ◽  
1996 ◽  
Vol 17 (6) ◽  
pp. 1157-1172 ◽  
Author(s):  
Allen Ebens ◽  
Katja Brose ◽  
E.David Leonardo ◽  
M.Gartz Hanson Jr ◽  
Friedhelm Bladt ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Motor Neurons ◽  
Neurotrophic Factor ◽  
Scatter Factor ◽  
Spinal Motor Neurons ◽  
Spinal Motor ◽  
Hepatocyte Growth

scholarly journals Glial Cell Line-Derived Neurotrophic Factor Promotes the Survival of Early Postnatal Spinal Motor Neurons in the Lateral and Medial Motor Columns in Slice Culture

2002 ◽  
Vol 22 (10) ◽  
pp. 3953-3962 ◽  
Author(s):  
Wojtek P. Rakowicz ◽  
Christopher S. Staples ◽  
Jeffrey Milbrandt ◽  
Janice E. Brunstrom ◽  
Eugene M. Johnson
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Motor Neurons ◽  
Neurotrophic Factor ◽  
Slice Culture ◽  
Spinal Motor Neurons ◽  
Spinal Motor ◽  
Motor Columns

The zebrafish detour gene is essential for cranial but not spinal motor neuron induction

Development ◽  
1999 ◽  
Vol 126 (12) ◽  
pp. 2727-2737 ◽  
Author(s):  
A. Chandrasekhar ◽  
H.E. Schauerte ◽  
P. Haffter ◽  
J.Y. Kuwada
Keyword(s):  
Spinal Cord ◽  
Cell Death ◽  
Motor Neuron ◽  
Motor Neurons ◽  
Spinal Motor Neuron ◽  
Neuronal Phenotype ◽  
Spinal Motor Neurons ◽  
Spinal Motor ◽  
Hh Signaling ◽  
Function Cell

The zebrafish detour (dtr) mutation generates a novel neuronal phenotype. In dtr mutants, most cranial motor neurons, especially the branchiomotor, are missing. However, spinal motor neurons are generated normally. The loss of cranial motor neurons is not due to aberrant hindbrain patterning, failure of neurogenesis, increased cell death or absence of hh expression. Furthermore, activation of the Hh pathway, which normally induces branchiomotor neurons, fails to induce motor neurons in the dtr hindbrain. Despite this, not all Hh-mediated regulation of hindbrain development is abolished since the regulation of a neural gene by Hh is intact in the dtr hindbrain. Finally, dtr can function cell autonomously to induce branchiomotor neurons. These results suggest that detour encodes a component of the Hh signaling pathway that is essential for the induction of motor neurons in the hindbrain but not in the spinal cord and that dtr function is required for the induction of only a subset of Hh-mediated events in the hindbrain.

scholarly journals Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS

iScience ◽  
2021 ◽  
pp. 102700
Author(s):  
Jennifer L. Shadrach ◽  
Wesley M. Stansberry ◽  
Allison M. Milen ◽  
Rachel E. Ives ◽  
Elizabeth A. Fogarty ◽  
...  
Keyword(s):  
Motor Neurons ◽  
Spinal Motor Neurons ◽  
Spinal Motor
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