scholarly journals The gangliosides as a possible molecular coupling factor between the proportion of radiosensitive cells in vitro and the metastatic potential in vivo within a human melanoma cell line

1997 ◽  
Vol 75 (5) ◽  
pp. 639-649 ◽  
Author(s):  
CP Thomas ◽  
A Buronfosse ◽  
J Portoukalian ◽  
B Fertil
Keyword(s):  
Cell Line ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
Metastatic Potential ◽  
Coupling Factor ◽  
Human Melanoma ◽  
Human Melanoma Cell Line ◽  
Human Melanoma Cell

scholarly journals An In Vitro-In Vivo Evaluation of the Antiproliferative and Antiangiogenic Effect of Flavone Apigenin against SK-MEL-24 Human Melanoma Cell Line

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Alexandra Ghiƫu ◽  
Ioana Zinuca Pavel ◽  
Stefana Avram ◽  
Brigitta Kis ◽  
Daliana Minda ◽  
...  
Keyword(s):  
Cell Line ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
Human Melanoma ◽  
Human Melanoma Cell Line ◽  
Human Melanoma Cell ◽  
Cell Growth And Migration ◽  
Vitro Effect

One of the most important class of natural compounds with successful preclinical results in the management of cancer is the flavonoids. Due to the plethora of biological activities, apigenin (4 ′ ,5,7 trihydroxyflavone) is a main representant of the flavone subclass. Although the antiproliferative and antiangiogenic effects of apigenin were studied on a significant number of human and murine melanoma cell lines, in order to complete the data existing in the literature, the aim of this study is to evaluate the in vitro effect of apigenin on SK-MEL-24 human melanoma cell line as well as in vivo on tumor angiogenesis using the aforementioned cell line on the chorioallantoic membrane assay. Results have shown that in the range of tested doses, the phytocompound presents significant antiproliferative, cytotoxic, and antimigratory potential at 30 μM, respectively, 60 μM. Moreover, the phytocompound in both tested concentrations limited melanoma cell growth and migration and induced a reduced angiogenic reaction limiting melanoma cell development.

Role of Protease-activated Receptor 1 in Tumor Metastasis Promoted by Tissue Factor

2001 ◽  
Vol 86 (11) ◽  
pp. 1210-1214 ◽  
Author(s):  
Michelle Bailly ◽  
William Konigsberg ◽  
Michael Bromberg
Keyword(s):  
Cell Line ◽  
Tissue Factor ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
Factor Viia ◽  
Metastatic Potential ◽  
Human Melanoma ◽  
Human Melanoma Cell Line ◽  
Human Melanoma Cell

SummaryTissue factor (TF) is a transmembrane glycoprotein that complexes with factor VIIa to initiate blood coagulation. We previously reported that expression of high levels of TF in a human melanoma cell line promotes metastasis. Both the cytoplasmic domain of TF and its extracellular domain complexed with factor VIIa are required for the meta-static effect. To further explore the mechanism of TF-mediated metastasis, we investigated the possibility that a protease-activated receptor (PAR) might play a role. For this purpose, we first determined the expression levels of the known PARs (PAR1-4) in a human melanoma cell line, SIT1, that has low endogenous levels of TF and low meta-static potential. We found negligible levels of all of the known PARs and transfection of this cell line with human TF cDNA did not alter expression of the known PARs. To study the possible role of PAR1 in TF-mediated metastasis, we prepared a panel of transfected cell lines with varying levels of TF and PAR1. Our studies show that TF promotes metastasis by a pathway that does not involve high expression of known PARs by tumor cells. In addition, while overexpression of PAR1 is insufficient to induce metastasis in cells with low TF expression, it enhances the metastatic potential of cells with high TF expression, indicating a possible synergy between TF and PAR1 in promoting metastasis.

scholarly journals Combined p14ARF and Interferon-β Gene Transfer to the Human Melanoma Cell Line SK-MEL-147 Promotes Oncolysis and Immune Activation

2020 ◽  
Vol 11 ◽  
Author(s):  
Otto Luiz Dutra Cerqueira ◽  
Maria Alejandra Clavijo-Salomon ◽  
Elaine Cristina Cardoso ◽  
Tharcisio Citrangulo Tortelli Junior ◽  
Samir Andrade Mendonça ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Cell Line ◽  
Melanoma Cell ◽  
Immune Activation ◽  
Melanoma Cell Line ◽  
Human Melanoma ◽  
Human Melanoma Cell Line ◽  
Human Melanoma Cell ◽  
Interferon Β

scholarly journals MIF inhibition reverts the gene expression profile of human melanoma cell line-induced MDSCs to normal monocytes

Genomics Data ◽  
2016 ◽  
Vol 7 ◽  
pp. 240-242 ◽  
Author(s):  
Sabine Waigel ◽  
Beatriz E. Rendon ◽  
Gwyneth Lamont ◽  
Jamaal Richie ◽  
Robert A. Mitchell ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Line ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
Human Melanoma ◽  
Human Melanoma Cell Line ◽  
Human Melanoma Cell
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