scholarly journals Amniotic membrane transplantation for persistent corneal epithelial defects in eyes after penetrating keratoplasty

Eye ◽  
2008 ◽  
Vol 23 (4) ◽  
pp. 840-848 ◽  
Author(s):  
B Seitz ◽  
S Das ◽  
R Sauer ◽  
D Mena ◽  
C Hofmann-Rummelt
Keyword(s):  
Amniotic Membrane ◽  
Penetrating Keratoplasty ◽  
Amniotic Membrane Transplantation ◽  
Corneal Epithelial

scholarly journals Stabilization of Bilateral Progressive Rheumatoid Corneal Melt with Infliximab

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Sheelah F. Antao ◽  
Tariq Ayoub ◽  
Hasan Tahir ◽  
Dipak N. Parmar
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Report ◽  
Amniotic Membrane ◽  
Conventional Treatment ◽  
Penetrating Keratoplasty ◽  
Amniotic Membrane Transplantation ◽  
Cyanoacrylate Glue ◽  
Ocular Discomfort ◽  
History Of ◽  
Ulcerative Keratitis

Purpose. To report the use of infliximab in the rapid stabilization of a case of progressive, bilateral rheumatoid peripheral ulcerative keratitis (PUK) that failed to respond to conventional immunosuppressive therapy.Methods. A single interventional case report.Results. A patient with rheumatoid arthritis presented with bilateral PUK following a 2-month history of ocular discomfort and redness. His systemic prednisolone (PDN) and methotrexate (MTX) were increased and, despite an initial favorable response, bilateral recurrent corneal perforations ensued. Both eyes underwent cyanoacrylate glue repair, amniotic membrane transplantation (AMT), and penetrating keratoplasty (PKP). Recurrence of the disease and bilateral perforations of the second PKP in both eyes prompted administration of intravenous infliximab immediately after the fourth PKP. The disease activity rapidly settled in both eyes, and at eighteen-month followup, after 12 infliximab infusions, the PUK remains quiescent with no further graft thinning or perforation.Conclusion. Infliximab can be used to arrest the progression of severe bilateral rheumatoid PUK in cases that are refractory to conventional treatment.

scholarly journals Amniotic membrane transplantation in a patient with impending perforated corneal ulcer caused by Streptococcus mitis: a case report

2019 ◽  
Author(s):  
Fang-Chi Hsiao ◽  
Yaa-Jyuhn James Meir ◽  
Lung-Kun Yeh ◽  
Hsin-Yuan Tan ◽  
Ching-Hsi Hsiao ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Penetrating Keratoplasty ◽  
Unusual Case ◽  
Corneal Ulcer ◽  
Amniotic Membrane Transplantation ◽  
Streptococcus Mitis ◽  
Continuous Administration ◽  
Case Presentation ◽  
Corneal Erosion ◽  
Corneal Scraping

Abstract Background: Streptococcus mitis (S. mitis) belongs to the viridan streptococci group which is rarely isolated as a causative pathogen of corneal ulcer. When it causes keratitis, penetrating keratoplasty (PK) might be necessary. Herein, we demonstrated amniotic membrane transplantation (AMT) can be an easier surgery with acceptable outcomes and less complication. Case presentation: A 63-year-old female Taiwanese presented with right persistent corneal ulcer for nine months. Culture from corneal scraping yielded S. mitis. A right eye descemetocele decreased from 3 mm in diameter to 0.8 mm after continuous administration of topical Vancomycin and Ceftriaxone for two weeks. Due to retarded healing, AMT was performed. Her corneal erosion healed and became clear gradually. Her visual acuity recovered from counting fingers initially to 20/200 finally 17 months after AMT. Conclusion: This unusual case illustrated that antibiotics plus AMT instead of PK may be an effective alternative treatment to promote epithelialization and reduce inflammation in corneas complicated by S. mitis keratitis.

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