scholarly journals Regional Cerebral Ischemia in the Gerbil: Measurement of Regional Cerebral Blood Flow by Quantitative Autoradiography

1986 ◽  
Vol 6 (3) ◽  
pp. 348-357 ◽  
Author(s):  
Toshiki Yoshimine ◽  
Toru Hayakawa ◽  
Kazuo Yamada ◽  
Osamu Takemoto ◽  
Amami Kato ◽  
...  

Alterations in the regional CBF after occlusion of the posterior communicating, middle cerebral, or common carotid artery were investigated in the gerbil with a quantitative autoradiographic technique using [14C]iodoantipyrine. Occlusion of the posterior communicating artery produced severe ischemia in the ipsilateral hippocampus, thalamus, and dorsal mesencephalon. Occlusion of the middle cerebral artery produced severe ischemia in the ipsilateral rostral and central cerebral cortex and lateral caudate–putamen. Occlusion of the common carotid artery produced ipsilateral hemispheric ischemia of variable degrees. The distribution and degree of cerebral ischemia produced by occlusion of one of these arteries correlated closely to the arterial territory and the extent of collateral blood supply. Since the areas affected after occlusion of the posterior communicating or middle cerebral artery differ, those models will be useful for the comparative investigation of the ischemia-related cerebral pathophysiology associated with different sites of primary lesion.

2019 ◽  
Vol 98 (6) ◽  
pp. 252-255

Introduction: Cerebrovascular events are among the most common causes of invalidity or death. The aim of treatment in acute cerebral ischemia is to restore the blood flow before irreversible necrosis of brain tissue and persistent neurologic deficit occur. Pharmacological, endovascular and surgical methods are employed in the treatment of these patients. Case report: The authors present a case report of a 56-year-old woman with acute cerebral ischemia caused by tandem occlusion of the left com- mon carotid artery and the M1 segment of middle cerebral artery. In the initial phase the patient was treated by intravenous thrombolysis with minimal success. Common carotid artery was occluded and mechanical extraction of embolus was successfully performed through direct carotid bifurcation puncture. Almost complete regression of neurologic deficit occurred after the endovascular recanalization. Occluded common carotid stump and bifurcation was considered as a source of embolization and therefore, to prevent further cerebrovascular event, a subclavian-carotid bypass was performed on the 15th day after the stroke. Conclusion: In the reported patient with symptomatic tandem occlusion of common carotid artery and the M1 part of middle cerebral artery, recanalization of cerebral artery was attained by the combination of pharmacological and endovascular method. Consequent subclavian-to-carotid bypass was performed in tertiary prevention of further cerebrovascular event.


Nosotchu ◽  
2014 ◽  
Vol 36 (4) ◽  
pp. 271-274
Author(s):  
Ryu Ubagai ◽  
Takehiro Suyama ◽  
Shin Yamashita ◽  
Rin Shimozato ◽  
Masahiro Murakami ◽  
...  

2004 ◽  
Vol 52 (1) ◽  
pp. 1-6 ◽  
Author(s):  
D. Yildiz ◽  
M. E. Gultiken ◽  
D. Bolat

Arterial vascularisation of the ovine pineal gland was investigated by latex injection preparations of the common carotid artery in 20 adult Akkaraman sheep brains under stereo light microscope. It was observed that the arterial supply comes exclusively from branches of the caudal cerebral artery. The pineal gland was found to contain a rich vascular network. This network also received a few branches from the caudal choroid rami.


1999 ◽  
Vol 31 (Supplement) ◽  
pp. S194
Author(s):  
N. Murase ◽  
T. Katsumura ◽  
T. Osada ◽  
T. Hamaoka ◽  
Y. Yamamoto ◽  
...  

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Hidetaka Mitsumura ◽  
Ayumi Arai ◽  
Teppei Komatsu ◽  
Kenichi Sakuta ◽  
Kenichiro Sakai ◽  
...  

Introduction: While the examination for the evaluation of right-to-left shunt (RLS) using contrast transcranial Doppler (TCD) is useful, insufficient temporal bone window interrupts the adequate TCD examination for precise diagnosis of RLS. Thus, we developed a novel probe (paste-able soft ultrasound probe; PSUP) attached to the cervix for RLS diagnosis. Hypothesis: Monitoring at carotid artery using PSUP can detect greater number of contrast microembolic signals (cMES) than that of TCD. Methods: Subjects were patients with ischemic stroke or transient ischemic attack who had one and more cMES in middle cerebral artery detected by screening test of TCD on admission. PSUP was a 2.0-MHz center frequency and had an equal property with TCD transducer. The shape was thin, soft, and square modified for adequate attachment to the neck. We monitored blood flow of unilateral middle cerebral artery by TCD and ipsilateral common carotid artery by PSUP simultaneously. After injection of saline agitated with air in the right antecubital vein, we performed single test without Valsalva maneuver (VM) and triple tests with VM. And then, we compared the number of cMES between PSUP and TCD among each patient. Results: We performed 48 simultaneous PSUP and TCD examination (12 studies without VM, and 36 studies with VM) on 12 patients (11 male, median age of 49 years) without any complication. The number of cMES on PSUP was significantly larger than that of TCD in all of 48 examination (345 vs. 206, p<0.001), in 12 studies without VM (72 vs. 37, p=0.017), and in 36 studies with VM (273 vs. 169, p<0.001). Conclusions: In order to evaluate the RLS, PSUP examination at common carotid artery is a powerful approach in comparison with TCD. For patients without sufficient temporal bone window, PSUP should play an important role of RLS diagnosis.


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