scholarly journals A conditional knockout resource for the genome-wide study of mouse gene function

Nature ◽  
2011 ◽  
Vol 474 (7351) ◽  
pp. 337-342 ◽  
Author(s):  
William C. Skarnes ◽  
Barry Rosen ◽  
Anthony P. West ◽  
Manousos Koutsourakis ◽  
Wendy Bushell ◽  
...  
Keyword(s):  
Gene Function ◽  
Mouse Gene ◽  
Conditional Knockout ◽  
Genome Wide ◽  
Genome Wide Study

scholarly journals A large-scale zebrafish gene knockout resource for the genome-wide study of gene function

2013 ◽  
Vol 23 (4) ◽  
pp. 727-735 ◽  
Author(s):  
G. K. Varshney ◽  
J. Lu ◽  
D. E. Gildea ◽  
H. Huang ◽  
W. Pei ◽  
...  
Keyword(s):  
Gene Function ◽  
Large Scale ◽  
Gene Knockout ◽  
Genome Wide ◽  
Genome Wide Study

scholarly journals Genome-wide study of methotrexate clearance replicates SLCO1B1

Blood ◽  
2013 ◽  
Vol 121 (6) ◽  
pp. 898-904 ◽  
Author(s):  
Laura B. Ramsey ◽  
John C. Panetta ◽  
Colton Smith ◽  
Wenjian Yang ◽  
Yiping Fan ◽  
...  
Keyword(s):  
Genetic Variations ◽  
Genome Wide ◽  
A Genome ◽  
Key Points ◽  
Genome Wide Study

Key Points A genome-wide study of the association of over 5 million SNPs with methotrexate clearance in 1279 patients treated with HDMTX in multicenter COG trials 9904 and 9905. We replicated the finding that inherited variations in SLCO1B1 are the most important genetic variations influencing methotrexate clearance.

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