scholarly journals Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Ioan Iacovache ◽  
Sacha De Carlo ◽  
Nuria Cirauqui ◽  
Matteo Dal Peraro ◽  
F. Gisou van der Goot ◽  
...  
Keyword(s):  
Formation Process ◽  
Pore Formation ◽  
Protein Fold ◽  
Novel Protein

scholarly journals Crystal Structure of the Ancient, Fe−S Scaffold IscA Reveals a Novel Protein Fold†

Biochemistry ◽  
2004 ◽  
Vol 43 (1) ◽  
pp. 133-139 ◽  
Author(s):  
Patrick W. Bilder ◽  
Huangen Ding ◽  
Marcia E. Newcomer
Keyword(s):  
Crystal Structure ◽  
Protein Fold ◽  
Novel Protein

scholarly journals Hemolytic Lectin CEL-III Heptamerizes via a Large Structural Transition from α-Helices to a β-Barrel during the Transmembrane Pore Formation Process

2014 ◽  
Vol 289 (18) ◽  
pp. 12805-12812 ◽  
Author(s):  
Hideaki Unno ◽  
Shuichiro Goda ◽  
Tomomitsu Hatakeyama
Keyword(s):  
Formation Process ◽  
Pore Formation ◽  
Structural Transition

scholarly journals Crystallographic Studies of Human MitoNEET

2007 ◽  
Vol 282 (46) ◽  
pp. 33242-33246 ◽  
Author(s):  
Xiaowei Hou ◽  
Rujuan Liu ◽  
Stuart Ross ◽  
Eric J. Smart ◽  
Haining Zhu ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Mitochondrial Membrane ◽  
Hydrophobic Interactions ◽  
Water Molecules ◽  
Outer Mitochondrial Membrane ◽  
Protein Fold ◽  
Close Proximity ◽  
Diabetes Drug ◽  
Mitochondrial Membrane Protein ◽  
Novel Protein

MitoNEET was identified as an outer mitochondrial membrane protein that can potentially bind the anti-diabetes drug pioglitazone. The crystal structure of the cytoplasmic mitoNEET (residues 33–108) is determined in this study. The structure presents a novel protein fold and contains a [2Fe-2S] cluster-binding domain. The [2Fe-2S] cluster is coordinated to the protein by Cys-72, Cys-74, Cys-83, and His-87 residues. This coordination is also novel compared with the traditional [2Fe-2S] cluster coordinated by four cysteines or two cysteines and two histidines. The cytoplasmic mitoNEET forms homodimers in solution and in crystal. The dimerization is mainly mediated by hydrophobic interactions as well as hydrogen bonds coordinated by two water molecules binding at the interface. His-87 residue, which plays an important role in the coordination of the [2Fe-2S] cluster, is exposed to the solvent on the dimer surface. It is proposed that mitoNEET dimer may interact with other proteins via the surface residues in close proximity to the [2Fe-2S] cluster.

Crystal structure of a hypothetical T2SS effector Lpg0189 from Legionella pneumophila reveals a novel protein fold

2020 ◽  
Vol 521 (3) ◽  
pp. 799-805
Author(s):  
Xiaofang Chen ◽  
Shan Liu ◽  
Sha Jiang ◽  
Xuecheng Zhang ◽  
Nannan Zhang ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Legionella Pneumophila ◽  
Protein Fold ◽  
Novel Protein

Zinc Fingers: A Novel Protein Fold for Nucleic Acid Recognition

1987 ◽  
Vol 52 (0) ◽  
pp. 473-482 ◽  
Author(s):  
A. Klug ◽  
D. Rhodes
Keyword(s):  
Nucleic Acid ◽  
Zinc Fingers ◽  
Protein Fold ◽  
Novel Protein

scholarly journals Insights from the Structure of Mycobacterium tuberculosis Topoisomerase I with a Novel Protein Fold

2016 ◽  
Vol 428 (1) ◽  
pp. 182-193 ◽  
Author(s):  
Kemin Tan ◽  
Nan Cao ◽  
Bokun Cheng ◽  
Andrzej Joachimiak ◽  
Yuk-Ching Tse-Dinh
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Topoisomerase I ◽  
Protein Fold ◽  
Novel Protein

The crystal structure of NGO0477 from Neisseria gonorrhoeae reveals a novel protein fold incorporating a helix-turn-helix motif

2010 ◽  
Vol 78 (7) ◽  
pp. 1798-1802 ◽  
Author(s):  
Jingshan Ren ◽  
Sarah Sainsbury ◽  
Joanne E. Nettleship ◽  
Nigel J. Saunders ◽  
Raymond J. Owens
Keyword(s):  
Crystal Structure ◽  
Neisseria Gonorrhoeae ◽  
Protein Fold ◽  
Novel Protein

scholarly journals A Novel Protein Fold and Extreme Domain Swapping in the Dimeric TorD Chaperone from Shewanella massilia

Structure ◽  
2003 ◽  
Vol 11 (2) ◽  
pp. 165-174 ◽  
Author(s):  
Samuel Tranier ◽  
Chantal Iobbi-Nivol ◽  
Catherine Birck ◽  
Marianne Ilbert ◽  
Isabelle Mortier-Barrière ◽  
...  
Keyword(s):  
Domain Swapping ◽  
Protein Fold ◽  
Novel Protein
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