What is the best first-line therapy for Helicobacter pylori infection?

2008 ◽  
Vol 5 (11) ◽  
pp. 606-607 ◽  
Author(s):  
Xavier Calvet
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

scholarly journals Additive Effect of Pronase on the Eradication Rate of First-Line Therapy for Helicobacter pylori Infection

Gut and Liver ◽  
2015 ◽  
Vol 9 (3) ◽  
Author(s):  
Chang Seok Bang ◽  
Yeon Soo Kim ◽  
Sang Hyun Park ◽  
Jin Bong Kim ◽  
Gwang Ho Baik ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Eradication Rate ◽  
Helicobacter Pylori Infection ◽  
Additive Effect ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

Modified bismuth quadruple therapy with low‐dose metronidazole as first‐line therapy for Helicobacter pylori infection

Helicobacter ◽  
2020 ◽  
Author(s):  
Gyu Young Pih ◽  
Kee Don Choi ◽  
Eun Jeong Gong ◽  
Hee Kyong Na ◽  
Ji Yong Ahn ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Low Dose ◽  
Helicobacter Pylori Infection ◽  
First Line ◽  
Quadruple Therapy ◽  
First Line Therapy ◽  
Line Therapy

Quadruple concomitant non-bismuth therapy vs. classical triple therapy as first line therapy for Helicobacter pylori infection

2016 ◽  
Vol 147 (5) ◽  
pp. 199-201
Author(s):  
Ana Campillo ◽  
Miriam Ostiz ◽  
Edurne Amorena ◽  
Marcos Kutz ◽  
Matilde La Iglesia
Keyword(s):  
Helicobacter Pylori ◽  
Triple Therapy ◽  
Helicobacter Pylori Infection ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

Levofloxacin-versus clarithromycin-based first line therapy for helicobacter pylori infection

2006 ◽  
Vol 38 ◽  
pp. S72
Author(s):  
A. Rispo ◽  
E. Di Girolamo ◽  
A. Cozzolino ◽  
L.M.A.T. Hamma ◽  
L. Pasquale
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

scholarly journals Efficacy of two-week quadruple bismuth treatment versus levofloxacin concomitant Helicobacter Pylori infection regimen as empirical first-line therapy Syrian patients. A randomized controlled trial.

2020 ◽  
Author(s):  
Marouf Muhammad Alhalabi ◽  
Mohammed Waleed Alassi ◽  
Kamal Alaa Eddin ◽  
Khaled Cheha
Keyword(s):  
Randomized Controlled Trial ◽  
Helicobacter Pylori ◽  
Controlled Trial ◽  
Helicobacter Pylori Infection ◽  
First Line ◽  
Open Label ◽  
Randomized Controlled ◽  
First Line Therapy ◽  
Line Therapy

Abstract Introduction: Antibiotic-resistant reduces the efficacy of conventional triple therapy for Helicobacter Pylori infections worldwide, lead to varying treatment protocols according to locations.Aim: Primary outcome was eradication rates of bismuth quadruple (BQ) and levofloxacin concomitant (LC) as empirical first-line treatment by intention to treat (ITT) in a referral hospital in Syria.Design: an open‑label parallel blind randomized controlled trial.Materials and Methods: We randomly assigned seventy-eight naïve who tested positive for Helicobacter Pylori gastric infection, with a 1:1 ratio to receive either BQ (bismuth subsalicylate 524 mg four times daily, doxycycline 100 mg, tinidazole 500 mg, and esomeprazole 20 mg, each twice daily for two weeks), or LC (levofloxacin 500 mg daily, tinidazole 500 mg, amoxicillin 1000 mg, and esomeprazole 20 mg each twice daily for two weeks). We confirmed Helicobacter Pylori eradication by stool antigen test by eight weeks.Results: Thirty-nine patients were allocated in each group. In the BQ group, thirty-eight patients completed the follow-up, thirty patients were cured. While in the LC group, thirty-nine completed the follow-up, thirty-two patients were cured. The ITT eradication rates of the BQ and LC groups were 76.92%, and 82.05%, respectively. Odds ratio with 95% confidence interval according to ITT was 1.371 [0.454-4.146]. We didn’t report serious adverse effects.Conclusions:Both therapy regimens had acceptable rates of eradication. we suggest using both regimens as empirical first-line therapy in the treatment of Helicobacter Pylori infection in the Syrian population.Clinicaltrial.gov, NCT04348786

scholarly journals The Trend of Eradication Rate of Helicobacter pylori Infection and Clinical Factors That Affect the Eradication of First-line Therapy

2010 ◽  
Vol 55 (6) ◽  
pp. 368 ◽  
Author(s):  
Dong Keun Cho ◽  
Seon Young Park ◽  
Won Ju Kee ◽  
Jeong Hyeon Lee ◽  
Ho Seok Ki ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Eradication Rate ◽  
Helicobacter Pylori Infection ◽  
Clinical Factors ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

scholarly journals Furazolidone-based first-line therapy for Helicobacter pylori infection in China: A meta-analysis

2016 ◽  
Vol 24 (33) ◽  
pp. 4484
Author(s):  
Xiang-Juan Qi ◽  
Bao-Xin Shi ◽  
Yong Jiang
Keyword(s):  
Helicobacter Pylori ◽  
Meta Analysis ◽  
Helicobacter Pylori Infection ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

scholarly journals First-line Helicobacter pylori Eradication Rate of the 10-day Hybrid Therapy

2020 ◽  
Vol 20 (4) ◽  
pp. 300-305
Author(s):  
Jeong Hun Park ◽  
Dongwoo Kim ◽  
Jung Wan Choe ◽  
Seung Young Kim ◽  
Sung Woo Jung ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Eradication Rate ◽  
Standard Dose ◽  
Dual Therapy ◽  
Helicobacter Pylori Infection ◽  
First Line ◽  
Hybrid Therapy ◽  
First Line Therapy ◽  
Line Therapy ◽  
Significant Difference

Background/Aims: To improve the eradication rate of a first-line therapy for Helicobacter pylori infection, alternate regimens such as sequential, concomitant, and hybrid therapies have been tried. The aim of this study was to evaluate the eradication rate of the 10-day hybrid therapy as a first-line therapy.Materials and Methods: This retrospective study enrolled 124 patients from the Korea University Ansan Hospital between April 2016 and December 2019. The 10-day hybrid therapy comprised 5 days of dual therapy (proton pump inhibitor [PPI] standard dose and amoxicillin 1 g, twice daily) followed by 5 days of quadruple therapy (PPI, amoxicillin 1 g, clarithromycin 500 mg, and metronidazole 500 mg, twice daily). We compared the 10-day hybrid therapy with the 10-day concomitant therapy comprising PPI, amoxicillin 1 g, clarithromycin 500 mg, and metronidazole 500 mg, twice daily. Eradication was assessed by a <sup>13</sup>C-urea breath test or gastroscopic biopsy at least 4 weeks after treatment completion.Results: The eradication rates of the 10-day hybrid and concomitant therapies were 74.2% (46/62) and 67.7% (42/62), respectively, in the intention-to-treat (ITT) analysis and 88.5% (46/52) and 82.4% (42/51), respectively, in the per-protocol (PP) analysis. There was no significant difference in the eradication rates between the two groups in the ITT (P=0.429) and PP analysis (P=0.380). Adverse events developed in 75.0% and 70.6% of patients in the hybrid and concomitant groups, respectively, but there was no significant difference (P=0.615).Conclusions: The 10-day hybrid therapy can be an option for a first-line therapy of Helicobacter pylori infection.

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