Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology

2006 ◽  
Vol 12 (2) ◽  
pp. 175-177 ◽  
Author(s):  
Julia Alter ◽  
Fang Lou ◽  
Adam Rabinowitz ◽  
HaiFang Yin ◽  
Jeffrey Rosenfeld ◽  
...  
Keyword(s):  
Morpholino Oligonucleotide ◽  
Systemic Delivery ◽  
Dystrophin Expression

scholarly journals Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles

2004 ◽  
Vol 102 (1) ◽  
pp. 198-203 ◽  
Author(s):  
Q. L. Lu ◽  
A. Rabinowitz ◽  
Y. C. Chen ◽  
T. Yokota ◽  
H. Yin ◽  
...  
Keyword(s):  
Skeletal Muscles ◽  
Systemic Delivery ◽  
Dystrophin Expression

Systemic Delivery of a Peptide-Linked Morpholino Oligonucleotide Neutralizes Mutant RNA Toxicity in a Mouse Model of Myotonic Dystrophy

2013 ◽  
Vol 23 (2) ◽  
pp. 109-117 ◽  
Author(s):  
Andrew J. Leger ◽  
Leocadia M. Mosquea ◽  
Nicholas P. Clayton ◽  
I-Huan Wu ◽  
Timothy Weeden ◽  
...  
Keyword(s):  
Mouse Model ◽  
Myotonic Dystrophy ◽  
Morpholino Oligonucleotide ◽  
Systemic Delivery ◽  
Rna Toxicity

Pharmacokinetic peculiarities of drugs used in the form of rapidly dispersible tablets (oral delivery system)

2020 ◽  
pp. 7-24
Author(s):  
Zhanna Kozlova ◽  
Ivan Krasnyuk ◽  
Yuliya Lebedeva ◽  
Ekaterina Odintsova
Keyword(s):  
Oral Mucosa ◽  
Oral Delivery ◽  
Chemical Properties ◽  
Rapid Onset ◽  
Systemic Circulation ◽  
Systemic Delivery ◽  
Onset Of Action ◽  
Mucosal Drug Delivery ◽  
Physical And Chemical ◽  
Pass Metabolism

Oral mucosal drug delivery is an alternative method of systemic delivery with several advantages over both injectable and enteral methods. Drugs that are absorbed through the oral mucosa directly enter the systemic circulation, passing through the gastrointestinal tract and first-pass metabolism in the liver due to oral mucosa being highly vascularised. This results in rapid onset of action for some drugs because of a more comfortable and convenient way of delivery than the intravenous one. But not all drugs can be administered through the oral mucosa due to characteristics of the oral mucosa and physical and chemical properties of the drug.

Sign in / Sign up

Export Citation Format

Share Document