scholarly journals Augmentation of Morphine-Induced Sensitization but Reduction in Morphine Tolerance and Reward in Delta-Opioid Receptor Knockout Mice

2008 ◽  
Vol 34 (4) ◽  
pp. 887-898 ◽  
Author(s):  
V I Chefer ◽  
T S Shippenberg
Keyword(s):  
Opioid Receptor ◽  
Knockout Mice ◽  
Morphine Tolerance ◽  
Delta Opioid Receptor

Mu and delta opioid receptor knockout mice show increased colonic sensitivity

2016 ◽  
Vol 21 (4) ◽  
pp. 623-634 ◽  
Author(s):  
D. Reiss ◽  
R.A. Ceredig ◽  
T. Secher ◽  
J. Boué ◽  
F. Barreau ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Knockout Mice ◽  
Delta Opioid Receptor

Increased Ethanol Self-Administration in delta-Opioid Receptor Knockout Mice

2001 ◽  
Vol 25 (9) ◽  
pp. 1249-1256 ◽  
Author(s):  
Amanda J. Roberts ◽  
Lisa H. Gold ◽  
Ilham Polis ◽  
Jeffrey S. McDonald ◽  
Dominique Filliol ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Knockout Mice ◽  
Delta Opioid Receptor ◽  
Self Administration

P.6.d.022 Behavioural responses induced by nicotine in delta-opioid receptor knockout mice

2006 ◽  
Vol 16 ◽  
pp. S518-S519
Author(s):  
F. Berrendero ◽  
L. Galeote ◽  
A. Bura ◽  
B.L. Kieffer ◽  
R. Maldonado
Keyword(s):  
Opioid Receptor ◽  
Knockout Mice ◽  
Delta Opioid Receptor ◽  
Behavioural Responses

scholarly journals An Emerging Role for the Delta Opioid Receptor in the Regulation of Mu Opioid Receptor Function

2007 ◽  
Vol 7 ◽  
pp. 64-73 ◽  
Author(s):  
Raphael Rozenfeld ◽  
Noura S. Abul-Husn ◽  
Ivone Gomez ◽  
Lakshmi A. Devi
Keyword(s):  
Opioid Receptor ◽  
Critical Role ◽  
Site Occupancy ◽  
Morphine Tolerance ◽  
Delta Opioid Receptor ◽  
Receptor Binding Site ◽  
Delta Opioid Receptors ◽  
Physiological Adaptations ◽  
Opiate Tolerance ◽  
The Impact

Morphine and related opiates are commonly used in the clinical management of various types of pain. However, the antinociceptive properties of morphine are often overshadowed by the development of tolerance and dependence following its chronic use. The mechanisms underlying opiate tolerance are not fully understood, but appear to involve numerous and complex physiological adaptations. Recently, a role for the heterodimerization of mu and delta opioid receptors in the development of morphine tolerance has been proposed. This novel mechanism could help us to understand several observations, such as the critical role of delta opioid receptor regulation, the impact of delta opioid receptor binding site occupancy, and the participation of beta-arrestin2, in the development of morphine tolerance.

scholarly journals Inflammatory pain is enhanced in delta opioid receptor-knockout mice

2008 ◽  
Vol 27 (10) ◽  
pp. 2558-2567 ◽  
Author(s):  
Claire Gavériaux-Ruff ◽  
Laurie A. Karchewski ◽  
Xavier Hever ◽  
Audrey Matifas ◽  
Brigitte L. Kieffer
Keyword(s):  
Opioid Receptor ◽  
Knockout Mice ◽  
Inflammatory Pain ◽  
Delta Opioid Receptor

Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice

2002 ◽  
Vol 17 (1) ◽  
pp. 155-159 ◽  
Author(s):  
Anna Castañé ◽  
Patricia Robledo ◽  
Audrey Matifas ◽  
Brigitte L. Kieffer ◽  
Rafael Maldonado
Keyword(s):  
Opioid Receptor ◽  
Knockout Mice ◽  
Withdrawal Syndrome ◽  
Delta Opioid Receptor

scholarly journals Retention of Supraspinal Delta-like Analgesia and Loss of Morphine Tolerance in δ Opioid Receptor Knockout Mice

Neuron ◽  
1999 ◽  
Vol 24 (1) ◽  
pp. 243-252 ◽  
Author(s):  
Yanxin Zhu ◽  
Michael A. King ◽  
Alwin G.P. Schuller ◽  
Joshua F. Nitsche ◽  
Maureen Reidl ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Knockout Mice ◽  
Morphine Tolerance ◽  
Δ Opioid Receptor
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