scholarly journals Ethanol Enhances Glutamate Transmission by Retrograde Dopamine Signaling in a Postsynaptic Neuron/Synaptic Bouton Preparation From the Ventral Tegmental Area

2008 ◽  
Vol 34 (5) ◽  
pp. 1233-1244 ◽  
Author(s):  
Chunyu Deng ◽  
Ke-Yong Li ◽  
Chunyi Zhou ◽  
Jiang-Hong Ye
Keyword(s):  
Ventral Tegmental Area ◽  
Postsynaptic Neuron ◽  
Glutamate Transmission ◽  
Ventral Tegmental ◽  
Dopamine Signaling

scholarly journals The role of dopamine in reward-related behavior: shining new light on an old debate

2020 ◽  
Vol 124 (2) ◽  
pp. 309-311
Author(s):  
Allan R. Wang ◽  
Alexa Groome ◽  
Lara Taniguchi ◽  
Neir Eshel ◽  
Brandon S. Bentzley
Keyword(s):  
Reinforcement Learning ◽  
Ventral Tegmental Area ◽  
Incentive Salience ◽  
Ventral Tegmental ◽  
Dopamine Signaling

The role dopamine plays in reward-related behaviors has been debated for decades. Heymann et al. (Heymann G, Jo YS, Reichard KL, McFarland N, Chavkin C, Palmiter RD, Soden ME, Zweifel LS. Neuron 105: 909–920, 2020) identify subpopulations of dopamine-producing neurons that separately mediate reward association and motivation. Their results help demonstrate that dopamine signaling may partake in both reinforcement learning and incentive salience functions, instantiated by neuropeptide-defined subpopulations of the ventral tegmental area with different projection targets.

scholarly journals Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine

2017 ◽  
Vol 23 (5) ◽  
pp. 1032-1045 ◽  
Author(s):  
David L. Bernstein ◽  
Preeti S. Badve ◽  
Jessica R. Barson ◽  
Caroline E. Bass ◽  
Rodrigo A. España
Keyword(s):  
Ventral Tegmental Area ◽  
Mesolimbic Dopamine ◽  
Ventral Tegmental ◽  
Dopamine Signaling

Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area

2011 ◽  
Vol 14 (4) ◽  
pp. 414-416 ◽  
Author(s):  
Manuel Mameli ◽  
Camilla Bellone ◽  
Matthew T C Brown ◽  
Christian Lüscher
Keyword(s):  
Synaptic Plasticity ◽  
Ventral Tegmental Area ◽  
Glutamate Transmission ◽  
Ventral Tegmental

scholarly journals Lateral hypothalamic orexin glucose-inhibited neurons may regulate reward-based feeding by modulating glutamate transmission in the ventral tegmental area

2020 ◽  
Vol 1731 ◽  
pp. 145808 ◽  
Author(s):  
Suraj B. Teegala ◽  
Zhenyu Sheng ◽  
Miloni S. Dalal ◽  
Pamela R. Hirschberg ◽  
Kevin D. Beck ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Lateral Hypothalamic ◽  
Glutamate Transmission ◽  
Ventral Tegmental

scholarly journals Elevated dopamine signaling from ventral tegmental area to prefrontal cortical parvalbumin neurons drives conditioned inhibition

2019 ◽  
Vol 116 (26) ◽  
pp. 13077-13086 ◽  
Author(s):  
Rongzhen Yan ◽  
Tianyu Wang ◽  
Qiang Zhou
Keyword(s):  
Ventral Tegmental Area ◽  
Conditioned Inhibition ◽  
Inhibitory Neurons ◽  
Neuron Activity ◽  
Prefrontal Cortical ◽  
Essential Properties ◽  
Ventral Tegmental ◽  
Dopamine Signaling ◽  
Dependent Learning ◽  
Optimal Adaptation

Conditioned inhibition is an important process to suppress learned responses for optimal adaptation, but its underlying biological mechanism is poorly understood. Here we used safety learning (SL)/fear discrimination after fear conditioning as a conditioned inhibition model because it demonstrates the essential properties of summation and retardation. Activity of the dorsomedial prefrontal cortex (dmPFC) parvalbumin (PV) neurons bidirectionally regulates spiking levels of dmPFC excitatory neurons and fear states. Responses to safety cues are increased in dopaminergic (DA) neurons in the ventral tegmental area (VTA) and in PV neurons in dmPFC after SL. Plasticity in the VTA is implicated, since SL requires activation ofN-methyl-d-aspartate receptors. Furthermore, in a posttraumatic stress disorder model, impaired SL is associated with impaired potentiation of VTA DA neuron activity. Our results demonstrate a DA-dependent learning process that targets prefrontal inhibitory neurons for suppression of learned responses, and have implications for the pathogenesis and treatment of various psychiatric diseases.

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