scholarly journals Novel Synthetic Opioids and Overdose Deaths: Tip of the Iceberg?

2017 ◽  
Vol 43 (1) ◽  
pp. 216-217 ◽  
Author(s):  
Michael H Baumann ◽  
Gavril W Pasternak
2021 ◽  
Vol 136 (1_suppl) ◽  
pp. 80S-86S
Author(s):  
Heather A. Clinton ◽  
Shobha Thangada ◽  
James R. Gill ◽  
Amy Mirizzi ◽  
Susan B. Logan

Objectives Drug overdose deaths in Connecticut increasingly involve a growing number of fentanyl analogs and other novel nonfentanyl synthetic opioids (ie, novel synthetics). Current postmortem toxicology testing methods often lack the sophistication needed to detect these compounds. We examined how improved toxicology testing of fatal drug overdoses can determine the prevalence and rapidly evolving trends of novel synthetics. Methods From 2016 to June 2019, the Connecticut Office of the Chief Medical Examiner increased its scope of toxicology testing of suspected drug overdose deaths in Connecticut from basic to enhanced toxicology testing to detect novel synthetics. The toxicology laboratory also expanded its testing panels during this time. We analyzed toxicology results to identify and quantify the involvement of novel synthetics over time. Results From 2016 to June 2019, 3204 drug overdose deaths received enhanced toxicology testing; novel synthetics were detected in 174 (5.4%) instances. Ten different novel synthetics were detected with 205 total occurrences. Of 174 overdose deaths with a novel synthetic detected, most had 1 (n = 146, 83.9%) or 2 (n = 26, 14.9%) novel synthetics detected, with a maximum of 4 novel synthetics detected. Para-fluorobutyrylfentanyl/FIBF, furanylfentanyl, and U-47700 were most identified overall, but specific novel synthetics came in and out of prominence during the study period, and the variety of novel synthetics detected changed from year to year. Conclusions Enhanced toxicology testing for drug overdose deaths is effective in detecting novel synthetics that are not identified through basic toxicology testing. Identifying emerging novel synthetics allows for a timely and focused response to potential drug outbreaks and illustrates the changing drug market.


2018 ◽  
Vol 37 (1) ◽  
pp. 215-223 ◽  
Author(s):  
Janna Lowry ◽  
Michael T. Truver ◽  
Madeleine J. Swortwood

2018 ◽  
Vol 134 ◽  
pp. 101-107 ◽  
Author(s):  
Michael H. Baumann ◽  
Susruta Majumdar ◽  
Valerie Le Rouzic ◽  
Amanda Hunkele ◽  
Rajendra Uprety ◽  
...  

2019 ◽  
Vol 4 (2) ◽  
pp. 111-140 ◽  
Author(s):  
Inês Tabarra ◽  
Sofia Soares ◽  
Tiago Rosado ◽  
Joana Gonçalves ◽  
Ângelo Luís ◽  
...  

2020 ◽  
Vol 44 (7) ◽  
pp. 672-678
Author(s):  
Rachel Bonk ◽  
Ross J Miller ◽  
Joshua Lanter ◽  
Cheryl Niblo ◽  
Jesse Kemp ◽  
...  

Abstract To evaluate trends related to accidental overdose deaths in Oklahoma, with a focus on opioids and methamphetamine. All accidental drug overdose deaths in the state of Oklahoma from 2002 to 2017 were reviewed. Opioids were grouped into the following categories: all opioids, prescription opioids, synthetic opioids and heroin. Age-adjusted death rates for methamphetamine and each opioid category were calculated and analyzed. Accidental overdoses accounted for 9,936 deaths during the study period. Of these, opioids were seen in 62.9%, with prescription opioids comprising 53.8%, synthetic opioids 10.3% and heroin 2.8%. Synthetic opioids, despite a recent upward nationwide trend, showed a slight overall decrease (−6.8%) from 2009 to 2017. In contrast, methamphetamine showed a 402.2% increase from 2009 to 2017 and an overall increase of 1,526.7%. Methamphetamine was involved in the most overdoses (1,963), followed by oxycodone (1,724). Opioid-related deaths were most common among white individuals (90.3%) and showed a slight male predilection (56.9%). With the intent of assessing the opioid epidemic as it relates to accidental overdoses in Oklahoma, this study suggests that opioid-related overdoses have slowed in recent years amidst a sharp increase in methamphetamine deaths.


2020 ◽  
Vol 308 ◽  
pp. 110175 ◽  
Author(s):  
Michael T. Truver ◽  
Madeleine J. Swortwood-Gates

2018 ◽  
Vol 134 ◽  
pp. 121-132 ◽  
Author(s):  
Patil Armenian ◽  
Kathy T. Vo ◽  
Jill Barr-Walker ◽  
Kara L. Lynch

Author(s):  
Gianfranco Stigliano ◽  
Andrea Miuli ◽  
Alessandra Vizziello ◽  
Arianna Ida Altomare ◽  
Aliseo Lalli ◽  
...  

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